Brevilin A

Modify Date: 2024-01-08 17:35:08

Brevilin A structure	Common Name	Brevilin A
	CAS Number	16503-32-5	Molecular Weight	346.417
	Density	1.2±0.1 g/cm3	Boiling Point	494.0±45.0 °C at 760 mmHg
	Molecular Formula	C₂₀H₂₆O₅	Melting Point	N/A
	MSDS	N/A	Flash Point	216.0±28.8 °C

Use of Brevilin A

Brevilin A is a sesquiterpene lactone isolated from Centipeda minima with anti-tumor activity. Brevilin A is a selective inhibitor of JAK-STAT signal pathway by attenuating the JAKs activity and blocking STAT3 signaling (IC50 = 10.6 µM) in Cancer Cells. Brevilin A induces apoptosis and autophagy via mitochondrial pathway and PI3K/AKT/mTOR inactivation in colon adenocarcinoma cell CT26[1][2].

Name	Brevilin A
Synonym	More Synonyms

Description	Brevilin A is a sesquiterpene lactone isolated from Centipeda minima with anti-tumor activity. Brevilin A is a selective inhibitor of JAK-STAT signal pathway by attenuating the JAKs activity and blocking STAT3 signaling (IC50 = 10.6 µM) in Cancer Cells. Brevilin A induces apoptosis and autophagy via mitochondrial pathway and PI3K/AKT/mTOR inactivation in colon adenocarcinoma cell CT26[1][2].
Related Catalog	Signaling Pathways >> Stem Cell/Wnt >> STAT Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> JAK/STAT Signaling >> JAK Signaling Pathways >> Epigenetics >> JAK Signaling Pathways >> Stem Cell/Wnt >> JAK Signaling Pathways >> JAK/STAT Signaling >> STAT Signaling Pathways >> Autophagy >> Autophagy
Target	IC50: 10.6 µM (STAT3 signaling)[1]
References	[1]. Chen X, et al. Brevilin A, a novel natural product, inhibits janus kinase activity and blocks STAT3 signaling in cancer cells. PLoS One. 2013 May 21;8(5):e63697. [2]. You P, et al. Brevilin A induces apoptosis and autophagy of colon adenocarcinoma cell CT26 via mitochondrial pathway and PI3K/AKT/mTOR inactivation. Biomed Pharmacother. 2018 Feb;98:619-625.

Density	1.2±0.1 g/cm3
Boiling Point	494.0±45.0 °C at 760 mmHg
Molecular Formula	C₂₀H₂₆O₅
Molecular Weight	346.417
Flash Point	216.0±28.8 °C
Exact Mass	346.178009
PSA	69.67000
LogP	2.98
Vapour Pressure	0.0±1.3 mmHg at 25°C
Index of Refraction	1.535

Hazard Codes	Xi

(3S,3aR,4S,4aR,7aR,8R,9aR)-3,4a,8-Trimethyl-2,5-dioxo-2,3,3a,4,4a,5,7a,8,9,9a-decahydroazuleno[6,5-b]furan-4-yl (2Z)-2-methyl-2-butenoate

2-Butenoic acid, 2-methyl-, (3S,3aR,4S,4aR,7aR,8R,9aR)-2,3,3a,4,4a,5,7a,8,9,9a-decahydro-3,4a,8-trimethyl-2,5-dioxoazuleno[6,5-b]furan-4-yl ester, (2Z)-

BioBioPha
China
Product Name: Brevilin A
Price: ￥Inquiry/10mg
Purity: 98.0%
Stocking Period: 1 Day
Contact: Xueping-Zheng

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Brevilin A
Price: ￥4480.0/5mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: Brevilin A
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Get all suppliers and price by the below link:

Brevilin A suppliers

Brevilin A price

Brevilin A

Use of Brevilin A

Names

Brevilin A Biological Activity

Chemical & Physical Properties

Safety Information

Synonyms