GR 203040结构式
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常用名 | GR 203040 | 英文名 | GR 203040 |
|---|---|---|---|---|
| CAS号 | 168398-02-5 | 分子量 | 437.37 | |
| 密度 | N/A | 沸点 | 560.4ºC at 760mmHg | |
| 分子式 | C20H26Cl2N6O | 熔点 | N/A | |
| MSDS | 美版 | 闪点 | 292.7ºC |
GR 203040用途
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GR203040 是一种具有口服活性的 NK1 受体拮抗剂,pKi 为 10.3。GR203040 显示出有效的止吐活性。 |
| 英文名 | N-[[2-methoxy-5-(tetrazol-1-yl)phenyl]methyl]-2-phenylpiperidin-3-amine |
|---|---|
| 英文别名 | 更多 |
| 描述 | GR203040 是一种具有口服活性的 NK1 受体拮抗剂,pKi 为 10.3。GR203040 显示出有效的止吐活性。 |
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| 相关类别 | |
| 靶点 |
pKi: 10.3 (NK1 receptor)[1] |
| 参考文献 |
| 沸点 | 560.4ºC at 760mmHg |
|---|---|
| 分子式 | C20H26Cl2N6O |
| 分子量 | 437.37 |
| 闪点 | 292.7ºC |
| 精确质量 | 364.20100 |
| PSA | 76.89000 |
| LogP | 2.97350 |
| 蒸汽压 | 1.37E-12mmHg at 25°C |
| 危险品运输编码 | NONH for all modes of transport |
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Attenuation of the gerbil writhing response by mu-, kappa- and delta-opioids, and NK-1, -2 and -3 receptor antagonists.
Pharmacol. Biochem. Behav. 79(1) , 125-35, (2004) Mu-, kappa- and delta-opioid receptor agonists are reported to attenuate the acetic-acid-induced abdominal constriction response in mice. NK-1, -2 and -3 receptor antagonists also display activity in ... |
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Brain uptake and receptor binding of two [11C]labelled selective high affinity NK1-antagonists, GR203040 and GR205171--PET studies in rhesus monkey.
Neuropharmacology 39(4) , 664-70, (2000) Two high affinity and selective NK1-receptor antagonists, GR203040 and GR205171, were labelled with 11C and used in a series of experiments in rhesus monkeys. The purpose of these studies was to evalu... |
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The broad-spectrum anti-emetic activity of the novel non-peptide tachykinin NK1 receptor antagonist GR203040.
Br. J. Pharmacol. 116(8) , 3158-63, (1995) 1. Following our earlier observations that the tachykinin NK1 receptor antagonist CP-99,994 is an effective anti-emetic in ferrets, we have examined the anti-emetic effects of a more potent and novel ... |
| 3-Piperidinamine,N-[[2-methoxy-5-(1H-tetrazol-1-yl)phenyl]methyl]-2-phenyl-,hydrochloride(1:2),(2S,3S) |
| 3-Piperidinamine,N-[[2-methoxy-5-(1H-tetrazol-1-yl)phenyl]methyl]-2-phenyl-,dihydrochloride,(2S-cis) |
| 3-Piperidinamine,N-[[2-methoxy-5-(1H-tetrazol-1-yl)phenyl]methyl]-2-phenyl-,dihydrochloride,(2S,3S)-(9CI) |
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