Zicronapine

• 常用名: Zicronapine
• 英文名: Zicronapine
• CAS号: 170381-16-5
• 分子量: 354.91600
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₂H₂₇ClN₂
• 熔点: N/A
• 闪点: N/A

Zicronapine用途

齐克罗纳平是一种抗精神病药物,在动物模型中具有强大的促认知作用,并有可能治疗许多神经和精神疾病。齐克罗纳平对多巴胺D1/D2和5-羟色胺5-HT2A受体有强烈的拮抗作用。

Zicronapine名称

• 英文名: 4-[(1R,3S)-6-chloro-3-phenyl-2,3-dihydro-1H-inden-1-yl]-1,2,2-trimethylpiperazine

Zicronapine生物活性

• 描述: 齐克罗纳平是一种抗精神病药物,在动物模型中具有强大的促认知作用,并有可能治疗许多神经和精神疾病。齐克罗纳平对多巴胺D1/D2和5-羟色胺5-HT2A受体有强烈的拮抗作用。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 多巴胺受体
  信号通路 >> 神经信号通路 >> 多巴胺受体
  研究领域 >> 神经疾病
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 5-HT受体
  信号通路 >> 神经信号通路 >> 5-HT受体
• 参考文献:

  [1]. Lopez De Diego, Heidi. et al. Succinate and malonate salts of trans-4-(1R,3S)-6-chloro-3-phenylindan-1-yl)-1,2,2-trimethylpiperazine and their preparation, pharmaceutical compositions, and use as medicaments, particularly as antipsychotics. WO2005016900A1

  [2]. Lundbeck H. A/S. The clinical phase III programme commenced on zicronapine. 20 Jan 2011.

  [3]. Lundbeck H, A/S. Zicronapine shows significant positive data in clinical phase II in the treatment of patients with schizophrenia –planning for continued clinical work. Press release No. 392 18 December 2009.

Zicronapine物理化学性质

• 分子式: C₂₂H₂₇ClN₂
• 分子量: 354.91600
• 精确质量: 354.18600
• PSA: 6.48000
• LogP: 4.81850
• InChIKey: BYPMJBXPNZMNQD-PZJWPPBQSA-N
• SMILES: CN1CCN(C2CC(c3ccccc3)c3ccc(Cl)cc32)CC1(C)C

Zicronapine靶点实验

查看更多实验

实验名称：Drug metabolism assessed as recombinant human liver CYP3A4-mediated formation of desm... 来源：ChEMBL 靶标：Cytochrome P450 3A4 External Id：CHEMBL5117878

实验名称：Drug metabolism assessed as recombinant human liver CYP3A4-mediated formation of d5-d... 来源：ChEMBL 靶标：Cytochrome P450 3A4 External Id：CHEMBL5117879

实验名称：Drug metabolism assessed as recombinant human liver CYP3A4-mediated formation of d5-d... 来源：ChEMBL 靶标：Cytochrome P450 3A4 External Id：CHEMBL5117880

实验名称：Drug metabolism assessed as recombinant human liver CYP2C19-mediated formation of d5-... 来源：ChEMBL 靶标：Cytochrome P450 2C19 External Id：CHEMBL5117874

实验名称：Drug metabolism assessed as recombinant human liver CYP3A4-mediated formation of desm... 来源：ChEMBL 靶标：Cytochrome P450 3A4 External Id：CHEMBL5117877

实验名称：Drug metabolism assessed as recombinant human liver CYP2C19-mediated formation of des... 来源：ChEMBL 靶标：Cytochrome P450 2C19 External Id：CHEMBL5117871

实验名称：Drug metabolism assessed as recombinant human liver CYP2C19-mediated formation of des... 来源：ChEMBL 靶标：Cytochrome P450 2C19 External Id：CHEMBL5117872

实验名称：Drug metabolism assessed as recombinant human liver CYP2C19-mediated formation of d5-... 来源：ChEMBL 靶标：Cytochrome P450 2C19 External Id：CHEMBL5117873

实验名称：Human D2 Binding Assay from US Patent US12116355: "Deuterated 1-piperazino-3-phenyl i... 来源：BindingDB 靶标：N/A External Id：BindingDB_12399_2

实验名称：Binding affinity to human dopamine D2 receptor 来源：ChEMBL 靶标：D(2) dopamine receptor External Id：CHEMBL4671577

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Zicronapine英文别名

• UNII-QZV11V7G6A
• Zicronapine