CPCCOEt

• 常用名: CPCCOEt
• 英文名: CPCCOEt
• CAS号: 179067-99-3
• 分子量: 247.24700
• 密度: 1.42g/cm3
• 沸点: 397.8ºC at 760mmHg
• 分子式: C₁₃H₁₃NO₄
• 熔点: N/A
• 闪点: 194.4ºC

CPCCOEt用途

CPCCOEt是代谢型谷氨酸受体1b(mGluR1b)[1][2]的一种低亲和力、选择性、非竞争性和可逆性拮抗剂。

CPCCOEt名称

• 英文名: CPCCOEt,7-(Hydroxyimino)cyclopropa[b]chromen-1a-carboxylateethylester

CPCCOEt生物活性

• 描述: CPCCOEt是代谢型谷氨酸受体1b(mGluR1b)[1][2]的一种低亲和力、选择性、非竞争性和可逆性拮抗剂。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 谷氨酸受体
  研究领域 >> 神经疾病
• 靶点实验:

  mGluR1b

• 参考文献:

  [1]. Litschig S, et al. CPCCOEt, a noncompetitive metabotropic glutamate receptor 1 antagonist, inhibits receptor signaling without affecting glutamate binding. Mol Pharmacol. 1999 Mar;55(3):453-61.

  [2]. Hermans E,et al. Reversible and non-competitive antagonist profile of CPCCOEt at the human type 1alpha metabotropic glutamate receptor. Neuropharmacology. 1998 Dec;37(12):1645-7.

CPCCOEt物理化学性质

• 密度: 1.42g/cm3
• 沸点: 397.8ºC at 760mmHg
• 分子式: C₁₃H₁₃NO₄
• 分子量: 247.24700
• 闪点: 194.4ºC
• 精确质量: 247.08400
• PSA: 68.12000
• LogP: 1.57910
• InChIKey: FXCTZFMSAHZQTR-KAMYIIQDSA-N
• SMILES: CCOC(=O)C12CC1C(=NO)c1ccccc1O2
• 蒸汽压: 4.82E-07mmHg at 25°C
• 折射率: 1.644

CPCCOEt安全信息

• 安全声明 (欧洲): 22-24/25
• 危险品运输编码: NONH for all modes of transport
• WGK德国: 3

CPCCOEt靶点实验

查看更多实验

实验名称：Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident pro... 来源：NCGC 靶标：N/A External Id：SERCaMPGLuc-p1-antagonist

实验名称：Human mGlu1 receptor (Metabotropic glutamate receptors) 来源：IUPHAR-DB 靶标：mGlu1 receptor (Metabotropic glutamate receptors) [Homo sapiens] External Id：289_Human

实验名称：Inhibition of Quisqualate-Induced PI Hydrolysis measured in CHO Metabotropic glutamat... 来源：ChEMBL 靶标：Metabotropic glutamate receptor 1 External Id：CHEMBL710045

实验名称：Agonist potency against cloned human metabotropic glutamate receptor 1 来源：ChEMBL 靶标：Metabotropic glutamate receptor 1 External Id：CHEMBL719076

实验名称：qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in... 来源：NCGC 靶标：TDP1 protein [Homo sapiens] External Id：TDP1100

实验名称：qHTS for Stage-Specific Inhibitors of Vaccinia Orthopoxvirus: mCherry Reporter Primar... 来源：NCGC 靶标：67.9K protein [Vaccinia virus] External Id：Vaccinia-p2mCherry

实验名称：Small-molecule inhibitors of ST2 (IL1RL1) 来源：20881 靶标：interleukin-1 receptor-like 1 isoform [homo sapiens] External Id：ST2_IL33_Inhibitors_Primary_Screening_77700

实验名称：qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in... 来源：NCGC 靶标：TDP1 protein [Homo sapiens] External Id：TDP1101

实验名称：Rescue cell viability in cybrid cells with a genetic mutation in complex 1 of the mit... 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：N/A External Id：HMS1315

实验名称：Agonist potency against cloned Metabotropic glutamate receptor 8 (mGluR-8). 来源：ChEMBL 靶标：Metabotropic glutamate receptor 8 External Id：CHEMBL712473

共40条，当前第1页，共4页

1

2

3

4

CPCCOEt英文别名

• CPCCOET
• Astemizole