依来曲普坦

• 常用名: 依来曲普坦
• 英文名: Almotriptan
• CAS号: 181183-52-8
• 分子量: 469.552
• 密度: 1.27g/cm3
• 沸点: 538.7ºC at 760mmHg
• 分子式: C₂₁H₃₁N₃O₇S
• 熔点: 170-172ºC
• 闪点: 279.6ºC

依来曲普坦用途

Almotriptan苹果酸盐是5-HT1B/1D受体激动剂,可作用于偏头疼。

依来曲普坦名称

• 中文名: 阿莫曲坦
• 英文名: almotriptan malate
• 中文别名: 依来曲普坦 | 马来酸阿莫曲普坦 | 苹果酸阿莫曲坦

依来曲普坦生物活性

• 描述: Almotriptan苹果酸盐是5-HT1B/1D受体激动剂,可作用于偏头疼。
• 相关类别:
  研究领域 >> 神经疾病
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 5-HT受体
  信号通路 >> 神经信号通路 >> 5-HT受体
• 参考文献:

  [1]. Bou J , et al. Pharmacological characterization of almotriptan: an indolic 5-HT receptor agonist for the treatment of migraine. Eur J Pharmacol, 2000. 410(1): p. 33-41.

  [2]. Gras J, et al. Safety profile of almotriptan, a new antimigraine agent. Effects on central nervous system, renal function and respiratory dynamics. Arzneimittelforschung, 2001. 51(9): p. 726-32.

依来曲普坦物理化学性质

• 密度: 1.27g/cm3
• 沸点: 538.7ºC at 760mmHg
• 熔点: 170-172ºC
• 分子式: C₂₁H₃₁N₃O₇S
• 分子量: 469.552
• 闪点: 279.6ºC
• 精确质量: 469.188263
• PSA: 159.62000
• LogP: 2.12290
• InChIKey: QHATUKWEVNMHRY-UHFFFAOYSA-N
• SMILES: CN(C)CCc1c[nH]c2ccc(CS(=O)(=O)N3CCCC3)cc12.O=C(O)CC(O)C(=O)O
• 外观性状: 淡黄色固体
• 蒸汽压: 1.13E-11mmHg at 25°C
• 储存条件: -20°C Freezer
• 水溶解性: 水溶性：可溶

依来曲普坦安全信息

• 危险品运输编码: NONH for all modes of transport

依来曲普坦靶点实验

查看更多实验

实验名称：AlphaScreen-based biochemical high throughput primary assay to identify inhibitors of... 来源：The Scripps Research Institute Molecular Screening Center 靶标：N/A External Id：ULK1_INH_LUMI_1536_1X%INH PRUN

实验名称：Discovery of Small Molecules to Inhibit Human Cytomegalovirus Nuclear Egress 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：HCMV UL50 External Id：HMS1262

实验名称：uHTS identification of small molecule modulators of Rev-erb Alpha. 来源：Burnham Center for Chemical Genomics 靶标：N/A External Id：SBCCG-A1016-RevErbaLBD-Primary-Assay

实验名称：Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VER... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4513082

实验名称：Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Cac... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4303805

实验名称：MELAS cybrid survival enhancement under low glucose conditions 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：N/A External Id：HMS1419

实验名称：SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response f... 来源：ChEMBL 靶标：Replicase polyprotein 1ab External Id：CHEMBL4495582

实验名称：Stabilization of p53 in human papillomavirus-positive cells 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：Cellular tumor antigen p53 External Id：HMS1485

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依来曲普坦英文别名

• 2-Hydroxybutandisäure--N,N-dimethyl-2-{5-[(pyrrolidin-1-ylsulfonyl)methyl]-1H-indol-3-yl}ethanamin(1:1)
• 2-Hydroxysuccinic acid - N,N-dimethyl-2-{5-[(1-pyrrolidinylsulfonyl)methyl]-1H-indol-3-yl}ethanamine (1:1)
• N,N-dimethyl-2-[5-(pyrrolidin-1-ylsulfonylmethyl)-1H-indol-3-yl]ethanamine,2-hydroxybutanedioic acid
• 2-hydroxybutanedioic acid - N,N-dimethyl-2-{5-[(pyrrolidin-1-ylsulfonyl)methyl]-1H-indol-3-yl}ethanamine (1:1)
• Almotriptan Malate
• N,N-Dimethyl-N-(2-(5-((1-pyrrolidinylsulfonyl)methyl)-1H-indol-2-yl)ethyl)amine - 2-Hydroxysuccinic Acid (1:1)
• 2-Hydroxysuccinic acid - N,N-dimethyl-2-{5-[(pyrrolidin-1-ylsulfonyl)methyl]-1H-indol-3-yl}ethanamine (1:1)
• ALMOTRIPTAN MALEATE
• Butanedioic acid, 2-hydroxy-, compd. with N,N-dimethyl-5-[(1-pyrrolidinylsulfonyl)methyl]-1H-indole-3-ethanamine (1:1)
• UNII:PJP312605E
• LAS 31416 dl-malate acid
• Axert
• butanedioic acid, 2-hydroxy-, compd. with 1-[[[3-[2-(dimethylamino)ethyl]-1H-indol-5-yl]methyl]sulfonyl]pyrrolidine (1:1)
• acide 2-hydroxybutanedioïque - N,N-diméthyl-2-{5-[(pyrrolidin-1-ylsulfonyl)méthyl]-1H-indol-3-yl}éthanamine (1:1)
• 1-[[[3-[2-(Dimethylamino)ethyl]-1H-indol-5-yl]methyl]sulfonyl]pyrrolidine Hydroxybutanedioate (1:1)
• Almotriptan (malate)