SU4984

• 常用名: SU4984
• 英文名: SU 4984
• CAS号: 186610-89-9
• 分子量: 333.38400
• 密度: 1.34g/cm3
• 沸点: 649.1ºC at 760 mmHg
• 分子式: C₂₀H₁₉N₃O₂
• 熔点: N/A
• 闪点: 346.4ºC

SU4984用途

SU4984是一种蛋白酪氨酸激酶抑制剂,成纤维细胞生长因子受体1(FGFR1)的IC50为10-20μM。SU4984还抑制血小板衍生生长因子受体和胰岛素受体。SU4984可用于癌症研究[1][2][3]。

SU4984名称

• 英文名: civentichem cv-409

SU4984生物活性

• 描述: SU4984是一种蛋白酪氨酸激酶抑制剂,成纤维细胞生长因子受体1(FGFR1)的IC50为10-20μM。SU4984还抑制血小板衍生生长因子受体和胰岛素受体。SU4984可用于癌症研究[1][2][3]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 蛋白酪氨酸激酶 >> PDGFR
  信号通路 >> 蛋白酪氨酸激酶 >> FGFR
  信号通路 >> 蛋白酪氨酸激酶 >> 胰岛素受体
• 靶点实验:

  FGFR1:10-20 μM (IC50)

• 体外研究: SU4984(5-100μM；5分钟)在1mM三磷酸腺苷(ATP)存在下,以10-20μM的IC50抑制FGFR1K的激酶活性[1]。SU4984(10-90μM；5分钟)抑制aFGF在NIH 3T3细胞中诱导的FGFR1的自身磷酸化,IC50为20-40μM[1]。SU4984(5μM)显著降低野生型受体的酪氨酸磷酸化,并降低组成型C2试剂盒的50%磷酸化[2]。SU4984(1-10μM；6天)杀死C2和P815细胞[2]。
• 参考文献:

  [1]. Mohammadi M, et, al. Structures of the tyrosine kinase domain of fibroblast growth factor receptor in complex with inhibitors. Science. 1997 May 9;276(5314):955-60.

  [2]. Ma Y, et, al. Indolinone derivatives inhibit constitutively activated KIT mutants and kill neoplastic mast cells. J Invest Dermatol. 2000 Feb;114(2):392-4.

SU4984物理化学性质

• 密度: 1.34g/cm3
• 沸点: 649.1ºC at 760 mmHg
• 分子式: C₂₀H₁₉N₃O₂
• 分子量: 333.38400
• 闪点: 346.4ºC
• 精确质量: 333.14800
• PSA: 52.65000
• LogP: 3.23450
• InChIKey: ZNFJBJDODKHWED-UHFFFAOYSA-N
• SMILES: O=CN1CCN(c2ccc(C=C3C(=O)Nc4ccccc43)cc2)CC1
• 蒸汽压: 9.81E-17mmHg at 25°C
• 折射率: 1.72
• 储存条件: 2-8°C，避光，干燥，密封

SU4984安全信息

• 危害码 (欧洲): Xi

SU4984靶点实验

查看更多实验

实验名称：Inhibition of EGFR in mouse HER14 cells assessed as inhibition of EGF-stimulated Shc ... 来源：ChEMBL 靶标：Epidermal growth factor receptor External Id：CHEMBL993550

实验名称：Inhibition of EGFR in mouse HER14 cells assessed as inhibition of EGF-stimulated ERK2... 来源：ChEMBL 靶标：Epidermal growth factor receptor External Id：CHEMBL993551

实验名称：Inhibition of insulin-stimulated insulin receptor beta subunit autophosphorylation in... 来源：ChEMBL 靶标：Insulin receptor External Id：CHEMBL993548

实验名称：Inhibition of EGF-stimulated EGFR phosphorylation in mouse HER14 cells by immunoblott... 来源：ChEMBL 靶标：Epidermal growth factor receptor External Id：CHEMBL993549

实验名称：Inhibition of insulin receptor in mouse NIHIR cells assessed as inhibition of insulin... 来源：ChEMBL 靶标：Insulin receptor External Id：CHEMBL961798

实验名称：Concentration required to achieve 50% inhibition of tyrosine phosphorylation on human... 来源：ChEMBL 靶标：Epidermal growth factor receptor External Id：CHEMBL676159

实验名称：Inhibition of EGFR phosphorylation in mouse NIH/3T3 cells at 200 uM 来源：ChEMBL 靶标：Epidermal growth factor receptor External Id：CHEMBL993552

实验名称：Concentration required to achieve 50% inhibition of tyrosine phosphorylation on murin... 来源：ChEMBL 靶标：Vascular endothelial growth factor receptor 1 External Id：CHEMBL818398

实验名称：Inhibition of insulin receptor tyrosine phosphorylation in mouse NIH3T3 cells 来源：ChEMBL 靶标：Insulin receptor External Id：CHEMBL993553

实验名称：Antiproliferative activity against human PM8910 cells at 10 uM after 72 hrs by MTS as... 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL3383526

共32条，当前第1页，共4页

1

2

3

4