SU 4984

Modify Date: 2024-01-10 07:48:18

SU 4984 structure	Common Name	SU 4984
	CAS Number	186610-89-9	Molecular Weight	333.38400
	Density	1.34g/cm3	Boiling Point	649.1ºC at 760 mmHg
	Molecular Formula	C₂₀H₁₉N₃O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	346.4ºC

Use of SU 4984

SU4984 is a protein tyrosine kinase inhibitor, with an IC50 of 10-20 μM for fibroblast growth factor receptor 1 (FGFR1). SU4984 is also inhibits platelet-derived growth factor receptor, and insulin receptor. SU4984 can be used for the research of cancer[1][2][3].

Name	civentichem cv-409

Description	SU4984 is a protein tyrosine kinase inhibitor, with an IC50 of 10-20 μM for fibroblast growth factor receptor 1 (FGFR1). SU4984 is also inhibits platelet-derived growth factor receptor, and insulin receptor. SU4984 can be used for the research of cancer[1][2][3].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Protein Tyrosine Kinase/RTK >> PDGFR Signaling Pathways >> Protein Tyrosine Kinase/RTK >> FGFR Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Insulin Receptor
Target	FGFR1:10-20 μM (IC50)
In Vitro	SU4984 (5-100 μM; 5 min) inhibits the kinase activity of FGFR1K with an IC50 of 10-20 μM in the presence of 1 mM adenosine triphosphate (ATP)[1]. SU4984 (10-90 μM; 5 min) inhibits the autophosphorylation of FGFR1 induced by aFGF in NIH 3T3 cells, with an IC50 of 20-40 μM[1]. SU4984 (5 μM) substantially reduces tyrosine phosphorylation of the wild-type receptor and reduces 50% phosphorylation of constitutive C2 KIT[2]. SU4984 (1-10 μM; 6 days) kills the C2 and P815 cells[2].
References	[1]. Mohammadi M, et, al. Structures of the tyrosine kinase domain of fibroblast growth factor receptor in complex with inhibitors. Science. 1997 May 9;276(5314):955-60. [2]. Ma Y, et, al. Indolinone derivatives inhibit constitutively activated KIT mutants and kill neoplastic mast cells. J Invest Dermatol. 2000 Feb;114(2):392-4.

Density	1.34g/cm3
Boiling Point	649.1ºC at 760 mmHg
Molecular Formula	C₂₀H₁₉N₃O₂
Molecular Weight	333.38400
Flash Point	346.4ºC
Exact Mass	333.14800
PSA	52.65000
LogP	3.23450
Vapour Pressure	9.81E-17mmHg at 25°C
Index of Refraction	1.72

Hazard Codes	Xi

DC Chemicals Limited
China
Product Name: SU4984
Price: ￥Inquiry/1g
Purity: 98.9%
Stocking Period: 1 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: CIVENTICHEM CV-409
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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Price: ￥770/10 mM * 1 mL in DMSO

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