薯蓣皂甙；薯蓣皂苷

• 常用名: 薯蓣皂甙；薯蓣皂苷
• 英文名: Dioscin
• CAS号: 19057-60-4
• 分子量: 869.044
• 密度: 1.4±0.1 g/cm3
• 沸点: N/A
• 分子式: C₄₅H₇₂O₁₆
• 熔点: 294-296 ℃
• 闪点: N/A

薯蓣皂甙；薯蓣皂苷用途

Dioscin(CCRIS 4123; Collettiside III)是天然的植物来源的甾体皂苷，针对多种癌细胞有较好的抗癌活性。

薯蓣皂甙；薯蓣皂苷名称

• 中文名: 薯蓣皂苷
• 英文名: dioscin
• 中文别名: 薯蓣皂甙 | 重楼皂苷III

薯蓣皂甙；薯蓣皂苷生物活性

• 描述: Dioscin(CCRIS 4123; Collettiside III)是天然的植物来源的甾体皂苷,针对多种癌细胞有较好的抗癌活性。
• 相关类别:
  信号通路 >> 自噬 >> 自噬
  研究领域 >> 癌症
  天然产物 >> 类固醇
• 参考文献:

  [1]. Chen J, et al. Dioscin-induced apoptosis of human LNCaP prostate carcinoma cells through activation of caspase-3 and modulation of Bcl-2 protein family. J Huazhong Univ Sci Technolog Med Sci. 2014 Feb;34(1):125-30.

  [2]. Qu X, et al. Dioscin inhibits osteoclast differentiation and bone resorption though down-regulating the Akt signaling cascades. Biochem Biophys Res Commun. 2014 Jan 10;443(2):658-65.

  [3]. Qin J, et al. Dioscin prevents the mitochondrial apoptosis and attenuates oxidative stress in cardiac H9c2 cells. Drug Res (Stuttg). 2014 Jan;64(1):47-52.

薯蓣皂甙；薯蓣皂苷物理化学性质

• 密度: 1.4±0.1 g/cm3
• 熔点: 294-296 ℃
• 分子式: C₄₅H₇₂O₁₆
• 分子量: 869.044
• 精确质量: 868.482056
• PSA: 235.68000
• LogP: 7.24
• InChIKey: VNONINPVFQTJOC-ZGXDEBHDSA-N
• SMILES: CC1CCC2(OC1)OC1CC3C4CC=C5CC(OC6OC(CO)C(OC7OC(C)C(O)C(O)C7O)C(O)C6OC6OC(C)C(O)C(O)C6O)CCC5(C)C4CCC3(C)C1C2C
• 折射率: 1.614
• 储存条件: 室温

薯蓣皂甙；薯蓣皂苷毒性和生态

薯蓣皂甙；薯蓣皂苷安全信息

• 危害码 (欧洲): Xi
• 安全声明 (欧洲): 24/25
• 海关编码: 29389090

薯蓣皂甙；薯蓣皂苷靶点实验

查看更多实验

实验名称：Cytotoxicity against human MCF7 cells after 72 hrs by SRB assay 来源：ChEMBL 靶标：MCF7 External Id：CHEMBL1006914

实验名称：Cytotoxicity against mouse P388 cells after 72 hrs by SRB assay 来源：ChEMBL 靶标：P388 External Id：CHEMBL1006913

实验名称：Cytotoxicity against human Lu1 cells after 72 hrs by SRB assay 来源：ChEMBL 靶标：Lu1 External Id：CHEMBL1006916

实验名称：Cytotoxicity against human LNCAP cells after 72 hrs by SRB assay 来源：ChEMBL 靶标：LNCaP External Id：CHEMBL1006915

实验名称：Cytotoxicity against human SK-MEL-2 cells after 72 hrs by SRB assay 来源：ChEMBL 靶标：SK-MEL-2 External Id：CHEMBL1006912

实验名称：Cytotoxicity against human SW626 cells after 72 hrs by SRB assay 来源：ChEMBL 靶标：SW626 External Id：CHEMBL1006921

实验名称：Cytotoxicity against human KB cells after 72 hrs by SRB assay 来源：ChEMBL 靶标：KB External Id：CHEMBL1006918

实验名称：Cytotoxicity against human KBV1 cells after 72 hrs by SRB assay 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL1006917

实验名称：Cytotoxicity against human BC1 cells after 72 hrs by SRB assay 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL1006920

实验名称：Cytotoxicity against human Col2 cells after 72 hrs by SRB assay 来源：ChEMBL 靶标：Col2 External Id：CHEMBL1006919

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薯蓣皂甙；薯蓣皂苷英文别名

• (3β,25R)-Spirost-5-en-3-yl 6-deoxy-α-L-mannopyranosyl-(1->2)-[6-deoxy-α-L-mannopyranosyl-(1->4)]-β-D-glucopyranoside
• collettisideiii
• (25R)-Spirost-5-en-3b-yl O-6-Deoxy-a-L-mannopyranosyl-(1®2)-O-[6-deoxy-a-L-mannopyranosyl-(1®4)]-b-D-glucopyranoside
• Dioscin
• polyphyllin III
• Diosgenin Bis-a-L-rhamnopyranosyl-(1®2 And 1®4)-b-D-Glucopyranoside