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薯蓣皂甙；薯蓣皂苷

薯蓣皂甙；薯蓣皂苷用途

Dioscin(CCRIS 4123; Collettiside III)是天然的植物来源的甾体皂苷,针对多种癌细胞有较好的抗癌活性。

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薯蓣皂甙；薯蓣皂苷名称

[ CAS 号 ]:
19057-60-4

[ 中文名 ]:
薯蓣皂苷

[ 英文名 ]:
Dioscin

[中文别名 ]:

[英文别名 ]:

collettisideiii
Dioscin
polyphyllin III

薯蓣皂甙；薯蓣皂苷生物活性

[ 描述 ]:

Dioscin(CCRIS 4123; Collettiside III)是天然的植物来源的甾体皂苷,针对多种癌细胞有较好的抗癌活性。

[ 相关类别 ]:

信号通路 >> 自噬 >> 自噬

研究领域 >> 癌症

天然产物 >> 类固醇

[参考文献]

[1]. Chen J, et al. Dioscin-induced apoptosis of human LNCaP prostate carcinoma cells through activation of caspase-3 and modulation of Bcl-2 protein family. J Huazhong Univ Sci Technolog Med Sci. 2014 Feb;34(1):125-30.

[2]. Qu X, et al. Dioscin inhibits osteoclast differentiation and bone resorption though down-regulating the Akt signaling cascades. Biochem Biophys Res Commun. 2014 Jan 10;443(2):658-65.

[3]. Qin J, et al. Dioscin prevents the mitochondrial apoptosis and attenuates oxidative stress in cardiac H9c2 cells. Drug Res (Stuttg). 2014 Jan;64(1):47-52.

[相关活性小分子]

薯蓣皂甙；薯蓣皂苷物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 熔点 ]:
294-296 â„ƒ

[ 分子式 ]:
C₄₅H₇₂O₁₆

[ 分子量 ]:
869.044

[ 精确质量 ]:
868.482056

[ PSA ]:
235.68000

[ LogP ]:
7.24

[ 折射率 ]:
1.614

[ 储存条件 ]:
室温

薯蓣皂甙；薯蓣皂苷毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LZ6405000

CHEMICAL NAME :: beta-D-Glucopyranoside, (3-beta,25R)-spirost-5-en-3-yl O-6-deoxy-alpha-L-mannopyranosyl-(1- 2)-O-(6-deoxy-alpha-L-mannopyranosyl)-(1-4))-

CAS REGISTRY NUMBER :: 19057-60-4

LAST UPDATED :: 199703

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C45-H72-O16

MOLECULAR WEIGHT :: 869.17

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JKXXAF Japanese Kokai Tokyo Koho Patents. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #91-271224

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薯蓣皂甙；薯蓣皂苷安全信息

[ 危害码 (欧洲) ]:
Xi

[ 安全声明 (欧洲) ]:
24/25

[ 海关编码 ]:
29389090