MS-PPOH

• 常用名: MS-PPOH
• 英文名: MS-PPOH
• CAS号: 206052-02-0
• 分子量: 327.439
• 密度: 1.1±0.1 g/cm3
• 沸点: N/A
• 分子式: C₁₆H₂₅NO₄S
• 熔点: N/A
• 闪点: N/A

MS-PPOH用途

MS-PPOH是一种有效的选择性细胞色素P450(CYP)环氧合酶抑制剂[1]。MS-PPOH抑制CYP2C8和CYP2C9的IC50分别为15和11µM[2]。

MS-PPOH名称

• 英文名: N-methylsulfonyl-6-(2-propoxyphenyl)hexanamide

MS-PPOH生物活性

• 描述: MS-PPOH是一种有效的选择性细胞色素P450(CYP)环氧合酶抑制剂[1]。MS-PPOH抑制CYP2C8和CYP2C9的IC50分别为15和11µM[2]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 代谢酶/蛋白酶 >> 细胞色素P450
  研究领域 >> 代谢疾病
  研究领域 >> 神经疾病
• 体外研究: MS-PPOH阻断细胞EET合成。MS-PPOH抑制强直(基础)细胞的侵袭和迁移,并降低11,12-EET(1.0μM)诱导的细胞运动[1]。细胞活力测定[1]细胞系：PC-3细胞浓度：2.0和10.0μM培养时间：24小时结果：抑制强直(基础)细胞的侵袭和迁移。
• 体内研究: MS-PPOH(20mg/kg/天,静脉注射)持续6天,可显著降低耐2%NaCl溶液的Dahl耐盐大鼠肾脏中环氧二十碳三烯酸(EET)的水平[3]。动物模型：6周大的易中风的雄性自发性高血压大鼠(SHRSP)[3]剂量：20 mg/kg/天给药：静脉注射结果：在1周后,治疗对盐水饮用SHRSP的收缩压(SBP)影响可忽略不计,160对167 mmHg,或治疗2周后,171对175 mmHg,溶媒对MS-PPOH,分别地
• 参考文献:

  [1]. Kasem Nithipatikom, et al. Inhibition of carcinoma cell motility by epoxyeicosatrienoic acid (EET) antagonists. Cancer Sci. 2010 Dec;101(12):2629-36.

  [2]. Jun Yang, et al. Cytochrome P450 2C24: Expression, Tissue Distribution, High-Throughput Assay, and Pharmacological Inhibition. Acta Pharm Sin B. 2012 Apr;2(2):137-145.

  [3]. Jing Li, et al. Pharmacological manipulation of arachidonic acid-epoxygenase results in divergent effects on renal damage. Front Pharmacol. 2014 Aug 15;5:187.

MS-PPOH物理化学性质

• 密度: 1.1±0.1 g/cm3
• 分子式: C₁₆H₂₅NO₄S
• 分子量: 327.439
• 精确质量: 327.150421
• PSA: 84.34000
• LogP: 3.16
• InChIKey: REUHFEYPDFRRGJ-UHFFFAOYSA-N
• SMILES: C#CCOc1ccccc1CCCCCC(=O)NS(C)(=O)=O
• 折射率: 1.517
• 储存条件: -20°C，密闭，干燥

MS-PPOH靶点实验

查看更多实验

实验名称：Discovery of Small Molecules to Inhibit Human Cytomegalovirus Nuclear Egress 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：HCMV UL50 External Id：HMS1262

实验名称：A screen for small molecules that modulate mitochondrial supercomplex formation 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：N/A External Id：HMS1482

实验名称：Cell-based high throughput primary assay to identify activators of GPR151 来源：The Scripps Research Institute Molecular Screening Center 靶标：RecName: Full=G-protein coupled receptor 151; AltName: Full=G-protein coupled receptor PGR7; AltName: Full=GPCR-2037; AltName: Full=Galanin receptor 4; AltName: Full=Galanin-receptor-like protein; Short=GalRL External Id：GPR151_PHUNTER_AG_LUMI_1536_1X%ACT

实验名称：AlphaScreen-based biochemical high throughput primary assay to identify inhibitors of... 来源：The Scripps Research Institute Molecular Screening Center External Id：MITF_INH_Alpha_1536_1X%INH PRUN

实验名称：Stabilization of p53 in human papillomavirus-positive cells 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：Cellular tumor antigen p53 External Id：HMS1485

实验名称：Discovering small molecule activators of G protein-gated inwardly-rectifying potassiu... 来源：15621 靶标：G protein-activated inward rectifier potassium channel 2 External Id：VANDERBILT_HTS_GIRK2_MPD

共6条，当前第1页，共1页

1

MS-PPOH英文别名

• N-(Methylsulfonyl)-6-(2-propoxyphenyl)hexanamide