TP-030-1

• 常用名: TP-030-1
• 英文名: TP-030-1
• CAS号: 2095514-75-1
• 分子量: 402.45
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₃H₂₂N₄O₃
• 熔点: N/A
• 闪点: N/A

TP-030-1用途

TP-030-1是RIPK1的抑制剂。TP-030-2抑制hRIPK1,Ki值为3.9nM,抑制mRIPK1(IC50值为4.2μM)。TP-030-1可用于炎症性疾病和神经退行性疾病的研究[1]。

TP-030-1名称

• 英文名: TP-030-1

TP-030-1生物活性

• 描述: TP-030-1是RIPK1的抑制剂。TP-030-2抑制hRIPK1,Ki值为3.9nM,抑制mRIPK1(IC50值为4.2μM)。TP-030-1可用于炎症性疾病和神经退行性疾病的研究[1]。
• 相关类别:
  信号通路 >> 细胞凋亡 >> RIP激酶
  研究领域 >> 炎症/免疫
  研究领域 >> 神经疾病
• 体外研究: TP-030-1以18nM的IC50值抑制HT29坏死[1]。TP-030-1以3.9nM的Ki值抑制hRIPK1[1]。TP-030-1以4.2μM的IC50值抑制mRIPK1[1]。
• 参考文献:

  [1]. Msato Yoshikawa, et al. Discovery of 7-Oxo-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridine Derivatives as Potent, Orally Available, and Brain-Penetrating Receptor Interacting Protein 1 (RIP1) Kinase Inhibitors: Analysis of Structure–Kinetic Relationships. J. Med. Chem. 2018, 61, 6, 2384–2409.

TP-030-1物理化学性质

• 分子式: C₂₃H₂₂N₄O₃
• 分子量: 402.45

TP-030-1靶点实验

查看更多实验

实验名称：This assay (PMID: 37558952) monitors the ability of a chemical compound (concentratio... 来源：ChEMBL 靶标：U2OS External Id：CHEMBL5724698

实验名称：Thermal Shift Assay. Domain: start/stop: M1-L298 来源：ChEMBL 靶标：Cyclin-dependent kinase 2 External Id：CHEMBL5062802

实验名称：Cell viability screening matched tumor and healthy colorectal patient-derived organoi... 来源：ChEMBL 靶标：Colon organoid External Id：CHEMBL5724804

实验名称：Thermal Shift Assay. Domain: start/stop: E122-S403 来源：ChEMBL 靶标：Aurora kinase A External Id：CHEMBL5067911

实验名称：Thermal Shift Assay. Domain: start/stop: M1-K294 来源：ChEMBL 靶标：Casein kinase I isoform delta External Id：CHEMBL5064195

实验名称：Sigma 1 Eurofins-Panlabs radioligand binding assay 来源：ChEMBL 靶标：Sigma non-opioid intracellular receptor 1 External Id：CHEMBL4884614

实验名称：Thermal Shift Assay. Domain: start/stop: S229-K512 来源：ChEMBL 靶标：Tyrosine-protein kinase ABL1 External Id：CHEMBL5060479

实验名称：Inhibition of fluorescent-labeled 3-(3-((3-(4-amino-5-(4-(3-(2-fluoro-5-(trifluoromet... 来源：ChEMBL 靶标：Receptor-interacting serine/threonine-protein kinase 1 External Id：CHEMBL4023996

实验名称：Inhibition of fluorescent-labeled 3-(3-((3-(4-amino-5-(4-(3-(2-fluoro-5-(trifluoromet... 来源：ChEMBL 靶标：Receptor-interacting serine/threonine-protein kinase 1 External Id：CHEMBL4023997

实验名称：Efflux ratio of apparent permeability from basolateral to apical side over apical to ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4023994

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