Nampt-IN-3

• 常用名: Nampt-IN-3
• 英文名: Nampt-IN-3
• CAS号: 2121591-52-2
• 分子量: 503.55
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₉H₂₅N₇O₂
• 熔点: N/A
• 闪点: N/A

Nampt-IN-3用途

Nampt-IN-3 (Compound 35) 同时抑制烟酰胺磷酸核糖转移酶 (NAMPT) 和 HDAC,IC50 分别为 31 nM 和 55 nM。Nampt-IN-3 有效诱导细胞凋亡 (apoptosis) 和自噬 (autophagy),最终导致细胞死亡。

Nampt-IN-3名称

• 英文名: Nampt-IN-3

Nampt-IN-3生物活性

• 描述: Nampt-IN-3 (Compound 35) 同时抑制烟酰胺磷酸核糖转移酶 (NAMPT) 和 HDAC,IC50 分别为 31 nM 和 55 nM。Nampt-IN-3 有效诱导细胞凋亡 (apoptosis) 和自噬 (autophagy),最终导致细胞死亡。
• 相关类别:
  信号通路 >> 细胞凋亡 >> 细胞凋亡
  研究领域 >> 癌症
  信号通路 >> 自噬 >> 自噬
  信号通路 >> 细胞周期/DNA损伤 >> HDAC
  信号通路 >> 代谢酶/蛋白酶 >> NAMPT
  信号通路 >> 表观遗传学 >> HDAC
• 参考文献:

  [1]. Dong G, et al. Small Molecule Inhibitors Simultaneously Targeting Cancer Metabolism and Epigenetics: Discovery of Novel Nicotinamide Phosphoribosyltransferase (NAMPT) and Histone Deacetylase (HDAC) Dual Inhibitors. J Med Chem. 2017 Oct 12;60(19):7965-7983.

Nampt-IN-3物理化学性质

• 分子式: C₂₉H₂₅N₇O₂
• 分子量: 503.55
• InChIKey: LSGNVZAEAAZOEH-UHFFFAOYSA-N
• SMILES: Nc1ccccc1NC(=O)c1ccc(Cn2cc(-c3ccc(C(=O)NCc4cccnc4)cc3)nn2)cc1

Nampt-IN-3靶点实验

查看更多实验

实验名称：Inhibition of NAMPT in human HCT116 cells assessed as decrease in NAD level after 24 ... 来源：ChEMBL 靶标：Nicotinamide phosphoribosyltransferase External Id：CHEMBL4019768

实验名称：Binding affinity of NAMPT in human HCT116 cells assessed as change in melting tempera... 来源：ChEMBL 靶标：Nicotinamide phosphoribosyltransferase External Id：CHEMBL4019769

实验名称：Inhibition of HDAC in human HCT116 cells assessed as increase in acetylated histone H... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4019766

实验名称：Inhibition of HDAC in human HCT116 cells assessed as increase in acetylated histone H... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4019767

实验名称：Cell cycle arrest in human HCT116 cells assessed as accumulation at G2 phase at 1 uM ... 来源：ChEMBL 靶标：HCT-116 External Id：CHEMBL4019764

实验名称：Cell cycle arrest in human HCT116 cells assessed as accumulation at G2 phase at 5 uM ... 来源：ChEMBL 靶标：HCT-116 External Id：CHEMBL4019765

实验名称：Induction of autophagy in human HCT116 cells assessed as increase in LC3-2 level at 5... 来源：ChEMBL 靶标：HCT-116 External Id：CHEMBL4019762

实验名称：Induction of autophagy in human HCT116 cells assessed as decrease in P-62 level at 5 ... 来源：ChEMBL 靶标：HCT-116 External Id：CHEMBL4019763

实验名称：Volume of distribution at steady state in Sprague-Dawley rat at 2 mg/kg, ip 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL4019774

实验名称：Plasma clearance in Sprague-Dawley rat at 2 mg/kg, ip 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL4019775

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