柯因二甲醚

• 常用名: 柯因二甲醚
• 英文名: Chrysin dimethylether
• CAS号: 21392-57-4
• 分子量: 282.291
• 密度: 1.2±0.1 g/cm3
• 沸点: 476.6±45.0 °C at 760 mmHg
• 分子式: C₁₇H₁₄O₄
• 熔点: 150-152ºC
• 闪点: 213.4±28.8 °C

柯因二甲醚用途

5,7-Dimethoxyflavone 是 Kaempferia parviflora 的主要成分之一,具有抗肥胖,抗炎和抗肿瘤作用。5,7-Dimethoxyflavone 抑制细胞色素 P450 (CYP) 3As。5,7-Dimethoxyflavone 也是有效的抗乳腺癌蛋白 (BCRP) 抑制剂。

柯因二甲醚名称

• 中文名: 柯因二甲醚
• 英文名: chrysin 5,7-dimethyl ether
• 中文别名: 5,7-二甲氧基黄酮

柯因二甲醚生物活性

• 描述: 5,7-Dimethoxyflavone 是 Kaempferia parviflora 的主要成分之一,具有抗肥胖,抗炎和抗肿瘤作用。5,7-Dimethoxyflavone 抑制细胞色素 P450 (CYP) 3As。5,7-Dimethoxyflavone 也是有效的抗乳腺癌蛋白 (BCRP) 抑制剂。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 代谢酶/蛋白酶 >> 细胞色素P450
  研究领域 >> 炎症/免疫
• 靶点实验:

  CYP3A

  Breast Cancer Resistance Protein (BCRP)

• 参考文献:

  [1]. Ochiai W, et al. Effect of the active ingredient of Kaempferia parviflora, 5,7-dimethoxyflavone, on the pharmacokinetics of midazolam. J Nat Med. 2018 Jun;72(3):607-614.

  [2]. Bae S, et al. Effect of 5,7-dimethoxyflavone on Bcrp1-mediated transport of sorafenib in vitro and in vivo in mice. Eur J Pharm Sci. 2018 May 30;117:27-34.

柯因二甲醚物理化学性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 476.6±45.0 °C at 760 mmHg
• 熔点: 150-152ºC
• 分子式: C₁₇H₁₄O₄
• 分子量: 282.291
• 闪点: 213.4±28.8 °C
• 精确质量: 282.089203
• PSA: 48.67000
• LogP: 3.27
• InChIKey: JRFZSUMZAUHNSL-UHFFFAOYSA-N
• SMILES: COc1cc(OC)c2c(=O)cc(-c3ccccc3)oc2c1
• 外观性状: 白色晶体
• 蒸汽压: 0.0±1.2 mmHg at 25°C
• 折射率: 1.598
• 储存条件: 2-8℃，避光，密封

柯因二甲醚安全信息

• 海关编码: 2914509090

柯因二甲醚海关

• 海关编码: 2914509090
• 中文概述: 2914509090 含其他含氧基的酮. 增值税率:17.0% 退税率:9.0% 监管条件:无 最惠国关税:5.5% 普通关税:30.0%
• 申报要素: 品名, 成分含量, 用途, 丙酮报明包装
• Summary: HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

柯因二甲醚靶点实验

查看更多实验

实验名称：Luminescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：mu-type opioid receptor isoform MOR-1 [Homo sapiens] External Id：OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify pos... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_PAM_FLUO8_1536_1X%ACT PRUN

实验名称：Minimum inhibitory concentration, that inhibits growth of Staphylococcus aureus in th... 来源：ChEMBL 靶标：Staphylococcus aureus External Id：CHEMBL800971

实验名称：Fluorescence polarization-based biochemical high throughput primary assay to identify... 来源：The Scripps Research Institute Molecular Screening Center 靶标：RecName: Full=Sialate O-acetylesterase; AltName: Full=H-Lse; AltName: Full=Sialic acid-specific 9-O-acetylesterase; Flags: Precursor [Homo sapiens] External Id：SIAE_INH_FP_1536_1X%INH PRUN

实验名称：MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Activator_SinglePoint... 来源：Broad Institute 靶标：N/A External Id：2084-01_Activator_SinglePoint_HTS_Activity

实验名称：Counterscreen for inhibitors of the fructose-bisphosphate aldolase (FBA) of M. tuberc... 来源：The Scripps Research Institute Molecular Screening Center 靶标：N/A External Id：GDH-TPI_INH_ABS_1536_1X%INH CSRUN

实验名称：Hedgehog Measured in Biochemical System Using Plate Reader - 2070-01_Inhibitor_Single... 来源：Broad Institute 靶标：hedgehog, isoform A [Drosophila melanogaster] External Id：2070-01_Inhibitor_SinglePoint_HTS_Activity

实验名称：Primary high throughput screening by co-culture imaging for identification hits as a ... 来源：23209 靶标：N/A External Id：UIHTS20180925

实验名称：qHTS for Inhibitors of TGF-b: Cytotox Counterscreen 来源：NCGC 靶标：N/A External Id：SMAD3201

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柯因二甲醚英文别名

• 5,7-dimethoxy-2-phenyl-4H-1-benzopyran-4-one
• Dimethylchrysin
• Chrysin DME
• 5,7-dimethoxyflavonone
• MFCD00016943
• 2-phenyl-5,7-dimethoxyl-flavone
• 4H-1-Benzopyran-4-one,5,7-dimethoxy-2-phenyl
• Chrysin 5,7-dimethyl ether
• 5,7-DIMETHOXYFLAVONE
• 5,7-dimethoxy-2-phenylchromen-4-one
• 5,7-dimethoxycrysin
• 5,7-dimethoxy-2-phenyl-chromen-4-one
• 5,7-Dimethoxy-2-phenyl-4H-chromen-4-one
• Chrysindimethylether
• Chrysin dimethylether