Homo-PROTAC cereblon降解剂1

• 常用名: Homo-PROTAC cereblon降解剂1
• 英文名: Homo-PROTAC cereblon degrader 1
• CAS号: 2244520-98-5
• 分子量: 660.63
• 密度: N/A
• 沸点: N/A
• 分子式: C₃₂H₃₂N₆O₁₀
• 熔点: N/A
• 闪点: N/A

Homo-PROTAC cereblon降解剂1用途

Homo-PROTAC cereblon degrader 1 (compound 15a) 是 CRBN 蛋白的高效降解剂,对IKZF1和IKZF3的影响很小。

Homo-PROTAC cereblon降解剂1名称

• 中文名: Homo-PROTAC cereblon降解剂1
• 英文名: Homo-PROTAC cereblon degrader 1

Homo-PROTAC cereblon降解剂1生物活性

• 描述: Homo-PROTAC cereblon degrader 1 (compound 15a) 是 CRBN 蛋白的高效降解剂,对IKZF1和IKZF3的影响很小。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 代谢酶/蛋白酶 >> E1/E2/E3酶
  信号通路 >> 蛋白裂解靶向嵌合体 >> PROTAC
• 靶点实验:

  Celeblon[1].

• 参考文献:

  [1]. Steinebach C, et al. Homo-PROTACs for the Chemical Knockdown of Cereblon. ACS Chem Biol. 2018 Sep 21;13(9):2771-2782.

Homo-PROTAC cereblon降解剂1物理化学性质

• 分子式: C₃₂H₃₂N₆O₁₀
• 分子量: 660.63
• InChIKey: OXIPFLHBDVDLDS-UHFFFAOYSA-N
• SMILES: O=C1CCC(N2C(=O)c3cccc(NCCOCCOCCNc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)c3C2=O)C(=O)N1
• 储存条件: 2-8℃

Homo-PROTAC cereblon降解剂1靶点实验

查看更多实验

实验名称：Protac activity at VHL/CRBN in HEK293 cells assessed as pVHL19 protein abundance at 1... 来源：ChEMBL 靶标：Protein cereblon External Id：CHEMBL4666440

实验名称：Protac activity at VHL/CRBN in HEK293 cells assessed as pVHL30 protein abundance at 1... 来源：ChEMBL 靶标：Protein cereblon External Id：CHEMBL4666443

实验名称：Protac activity at VHL/CRBN in human HeLa cells assessed as CRBN protein abundance af... 来源：ChEMBL 靶标：Protein cereblon External Id：CHEMBL4666511

实验名称：Protac activity at VHL/CRBN in HEK293 cells assessed as pVHL30 protein abundance at 1... 来源：ChEMBL 靶标：Protein cereblon External Id：CHEMBL4666446

实验名称：Protac activity at VHL/CRBN in HEK293 cells assessed as pVHL19 protein abundance at 1... 来源：ChEMBL 靶标：Protein cereblon External Id：CHEMBL4666437

实验名称：Protac activity at CRBN/ IKZF1 in human MM1S cells assessed as IKZF1 degradation by m... 来源：ChEMBL 靶标：Protein cereblon External Id：CHEMBL4374304

实验名称：Protac activity at VHL/CRBN in human HeLa cells assessed as induction of VHL degradat... 来源：ChEMBL 靶标：Protein cereblon External Id：CHEMBL4666532

实验名称：Protac activity at VHL/CRBN in human HeLa cells assessed as pVHL30 protein abundance ... 来源：ChEMBL 靶标：Protein cereblon External Id：CHEMBL4666503

实验名称：Protac activity at VHL/CRBN in HEK293 cells assessed as CRBN protein abundance after ... 来源：ChEMBL 靶标：Protein cereblon External Id：CHEMBL4666471

实验名称：Protac activity at VHL/CRBN in human HeLa cells assessed as pVHL19 protein abundance ... 来源：ChEMBL 靶标：Protein cereblon External Id：CHEMBL4666521

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