BCL6-IN-9

• 常用名: BCL6-IN-9
• 英文名: BCL6-IN-9
• CAS号: 2378852-76-5
• 分子量: 457.86
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₂H₁₈ClF₂N₅O₂
• 熔点: N/A
• 闪点: N/A

BCL6-IN-9用途

BCL6-IN-9(化合物1)是一种有效的B细胞淋巴瘤6蛋白(BCL6)抑制剂,IC50为3.9 nM。BCL6-IN-9可用于癌症研究[1]。

BCL6-IN-9名称

• 英文名: BCL6-IN-9

BCL6-IN-9生物活性

• 描述: BCL6-IN-9(化合物1)是一种有效的B细胞淋巴瘤6蛋白(BCL6)抑制剂,IC50为3.9 nM。BCL6-IN-9可用于癌症研究[1]。
• 相关类别:
  信号通路 >> 细胞凋亡 >> Bcl-2家族
  研究领域 >> 癌症
• 靶点实验:

  IC50: 3.9 nM (B-cell lymphoma 6 protein)[1]

• 参考文献:

  [1]. Davis OA, et, al. Optimizing Shape Complementarity Enables the Discovery of Potent Tricyclic BCL6 Inhibitors. J Med Chem. 2022 Jun 3.

BCL6-IN-9物理化学性质

• 分子式: C₂₂H₁₈ClF₂N₅O₂
• 分子量: 457.86

BCL6-IN-9靶点实验

查看更多实验

实验名称：HTRF Assay from US Patent US20230287003: "BCL6 INHIBITORS" 来源：BindingDB 靶标：N/A External Id：BindingDB_11468_1

实验名称：Permeability of the compound at pH 7.4 by PAMPA 来源：ChEMBL 靶标：N/A External Id：CHEMBL5136206

实验名称：Apparent permeability of compound in human Caco-2 cells from apical to basal measured... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5340432

实验名称：Efflux ratio of apparent permeability in human Caco-2 cells 来源：ChEMBL 靶标：N/A External Id：CHEMBL5340433

实验名称：Inhibition of human C-terminal nanoLuc-tagged BCL6 expressed in HEK293T cells co-expr... 来源：ChEMBL 靶标：B-cell lymphoma 6 protein External Id：CHEMBL5136201

实验名称：Intrinsic microsomal clearance in CD1 mouse liver microsomes at 1 uM preincubated for... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5340430

实验名称：Inhibition of human N-terminal thioredoxin 6-His tagged BCL6 BTB domain (5 to 129 res... 来源：ChEMBL 靶标：B-cell lymphoma 6 protein External Id：CHEMBL5136202

实验名称：Lipophilicity, logD of compound at pH 7.4 by HPLC analysis 来源：ChEMBL 靶标：N/A External Id：CHEMBL5340431

实验名称：Inhibition of C-terminal NanoLuc-fused BCL6 (unknown origin)/Halo-tagged SMRT (unknow... 来源：ChEMBL 靶标：Nuclear receptor corepressor 2 External Id：CHEMBL5340428

实验名称：Aqueous solubility of the compound measured after 20 hrs by NMR analysis 来源：ChEMBL 靶标：N/A External Id：CHEMBL5340429

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