IDO1/TDO-IN-1

• 常用名: IDO1/TDO-IN-1
• 英文名: IDO1/TDO-IN-1
• CAS号: 2379527-72-5
• 分子量: 364.35
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₁H₁₆O₆
• 熔点: N/A
• 闪点: N/A

IDO1/TDO-IN-1用途

IDO1/TDO-IN-1(30)是一种有效的双重IDO1(无竞争性,Ki为0.23μM)和TDO(竞争性,Ki为0.73μM)抑制剂。IDO1/TDO-IN-1(30)通过潜在的线粒体介导的Bcl-2/Bax途径显著促进细胞凋亡【1】。

IDO1/TDO-IN-1名称

• 英文名: IDO1/TDO-IN-1

IDO1/TDO-IN-1生物活性

• 描述: IDO1/TDO-IN-1(30)是一种有效的双重IDO1(无竞争性,Ki为0.23μM)和TDO(竞争性,Ki为0.73μM)抑制剂。IDO1/TDO-IN-1(30)通过潜在的线粒体介导的Bcl-2/Bax途径显著促进细胞凋亡【1】。
• 相关类别:
  信号通路 >> 细胞凋亡 >> Bcl-2家族
  信号通路 >> 细胞凋亡 >> 细胞凋亡
  研究领域 >> 癌症
  信号通路 >> 代谢酶/蛋白酶 >> 吲哚胺2,3-二氧化酶(IDO)
• 靶点实验:

  IDO1:0.23 μM (Ki)

  TDO:0.73 μM (Ki)

• 参考文献:

  [1]. Jiangxin Liu, et al. Discovery and biological evaluation of tanshinone derivatives as potent dual inhibitors of indoleamine 2, 3-dioxygenase 1 and tryptophan 2, 3-dioxygenase. Eur J Med Chem. 2022 May 5;235:114294.

IDO1/TDO-IN-1物理化学性质

• 分子式: C₂₁H₁₆O₆
• 分子量: 364.35
• InChIKey: HBGFMECMJXIZLM-UHFFFAOYSA-N
• SMILES: CC(=O)OCc1coc2c1C(=O)C(=O)c1c-2ccc2c1C=CC(=O)C2(C)C

IDO1/TDO-IN-1靶点实验

查看更多实验

实验名称：Competitive inhibition of recombinant human TDO measured by UV/visible spectrophotome... 来源：ChEMBL 靶标：Tryptophan 2,3-dioxygenase External Id：CHEMBL5163485

实验名称：Non-competitive inhibition of recombinant human IDO1 measured by UV/visible spectroph... 来源：ChEMBL 靶标：Indoleamine 2,3-dioxygenase 1 External Id：CHEMBL5163484

实验名称：Induction of apoptosis in human HeLa cells assessed apoptotic cells at 5 uM measured ... 来源：ChEMBL 靶标：HeLa External Id：CHEMBL5163487

实验名称：Induction of apoptosis in human HeLa cells assessed apoptotic cells at 10 uM measured... 来源：ChEMBL 靶标：HeLa External Id：CHEMBL5163486

实验名称：Hemolytic activity in rat RBC at 500 uM incubated for 30 mins 来源：ChEMBL 靶标：Erythrocyte External Id：CHEMBL5163493

实验名称：Induction of apoptosis in human HeLa cells assessed as increase in Bax/Bcl-2 ratio at... 来源：ChEMBL 靶标：HeLa External Id：CHEMBL5163492

实验名称：Induction of apoptosis in IFNgamma-stimulated human HeLa cells assessed apoptotic cel... 来源：ChEMBL 靶标：HeLa External Id：CHEMBL5163489

实验名称：Induction of apoptosis in human HeLa cells assessed apoptotic cells at 5 uM measured ... 来源：ChEMBL 靶标：HeLa External Id：CHEMBL5163488

实验名称：Induction of apoptosis in human HeLa cells assessed as increase in Bax expression at ... 来源：ChEMBL 靶标：HeLa External Id：CHEMBL5163491

实验名称：Induction of apoptosis in human HeLa cells assessed as decrease in Bcl-2 expression a... 来源：ChEMBL 靶标：HeLa External Id：CHEMBL5163490

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