Hyperforin dicyclohexylammonium salt

• 常用名: Hyperforin dicyclohexylammonium salt
• 英文名: Hyperforin dicyclohexylammonium salt
• CAS号: 238074-03-8
• 分子量: 718.10300
• 密度: N/A
• 沸点: N/A
• 分子式: C₄₇H₇₅NO₄
• 熔点: N/A
• 闪点: N/A
• 符号: GHS05, GHS07, GHS09
• 信号词: Danger

Hyperforin dicyclohexylammonium salt用途

Hyperforin dicyclohexylammonium salt (Hyperforin DCHA) 是一种瞬时受体典型 6 (TRPC6) 通道激活剂。Hyperforin dicyclohexylammonium salt 通过激活 Ca2+ 传导非选择性典型 TRPC6 通道来调节 Ca2+ 水平。Hyperforin dicyclohexylammonium salt 具有抗抑郁作用。

Hyperforin dicyclohexylammonium salt名称

• 英文名: N-cyclohexylcyclohexanamine,(1R,5R,6R,7S)-2-hydroxy-6-methyl-1,3,7-tris(3-methylbut-2-enyl)-6-(4-methylpent-3-enyl)-5-(2-methylpropanoyl)bicyclo[3.3.1]non-2-ene-4,9-dione

Hyperforin dicyclohexylammonium salt生物活性

• 描述: Hyperforin dicyclohexylammonium salt (Hyperforin DCHA) 是一种瞬时受体典型 6 (TRPC6) 通道激活剂。Hyperforin dicyclohexylammonium salt 通过激活 Ca2+ 传导非选择性典型 TRPC6 通道来调节 Ca2+ 水平。Hyperforin dicyclohexylammonium salt 具有抗抑郁作用。
• 相关类别:
  信号通路 >> 跨膜转运 >> 钙通道
  信号通路 >> 跨膜转运 >> TRP频道
  研究领域 >> 神经疾病
• 体外研究: 高福林二环己基铵盐(Hyperforin-DCHA)具有多向作用机制。它阻断配体门控(GABA、NMDA和AMPA受体)和电压门控通道(Ca2+、K+和Na+)[2]的电导。
• 参考文献:

  [1]. Heiser JH, et al. TRPC6 channel-mediated neurite outgrowth in PC12 cells and hippocampal neurons involves activation of RAS/MEK/ERK, PI3K, and CAMKIV signaling. J Neurochem. 2013 Nov;127(3):303-13.

  [2]. Pochwat B, et al. Hyperforin Potentiates Antidepressant-Like Activity of Lanicemine in Mice. Front Mol Neurosci. 2018 Dec 12;11:456.

Hyperforin dicyclohexylammonium salt物理化学性质

• 分子式: C₄₇H₇₅NO₄
• 分子量: 718.10300
• 精确质量: 717.57000
• PSA: 83.47000
• LogP: 12.62200
• InChIKey: KJVNMVCMFQAPDM-DNSWOBEMSA-N
• SMILES: C1CCC(NC2CCCCC2)CC1.CC(C)=CCCC1(C)C(CC=C(C)C)CC2(CC=C(C)C)C(=O)C1(C(=O)C(C)C)C(=O)C(CC=C(C)C)=C2O
• 储存条件: -20°C，密闭，干燥

Hyperforin dicyclohexylammonium salt安全信息

• 符号: GHS05, GHS07, GHS09
• 信号词: Danger
• 危害声明: H302-H314-H400
• 警示性声明: P273-P280-P305 + P351 + P338-P310
• 危险品运输编码: UN 1759 8 / PGIII

Hyperforin dicyclohexylammonium salt靶点实验

查看更多实验

实验名称：Antibacterial activity against Staphylococcus aureus ATCC 29213 after 18 hrs by MTT a... 来源：ChEMBL 靶标：Staphylococcus aureus External Id：CHEMBL2427010

实验名称：Antibacterial activity against Staphylococcus aureus ATCC 25923 after 18 hrs by MTT a... 来源：ChEMBL 靶标：Staphylococcus aureus External Id：CHEMBL2427009

实验名称：Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 43300... 来源：ChEMBL 靶标：Staphylococcus aureus External Id：CHEMBL2427008

实验名称：Antibacterial activity against Staphylococcus aureus EMRSA-15 after 18 hrs by MTT ass... 来源：ChEMBL 靶标：Staphylococcus aureus External Id：CHEMBL2427007

实验名称：Antibacterial activity against Enterococcus faecalis ATCC 29212 after 18 hrs by MTT a... 来源：ChEMBL 靶标：Enterococcus faecalis External Id：CHEMBL2427002

实验名称：Antibacterial activity against Escherichia coli ATCC 25922 after 18 hrs by MTT assay 来源：ChEMBL 靶标：Escherichia coli External Id：CHEMBL2427001

实验名称：Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 43300... 来源：ChEMBL 靶标：Staphylococcus aureus External Id：CHEMBL2427000

实验名称：Antibacterial activity against Staphylococcus aureus ATCC 29213 after 18 hrs by XTT a... 来源：ChEMBL 靶标：Staphylococcus aureus External Id：CHEMBL2426999

实验名称：Antibacterial activity against Staphylococcus aureus SA1199B after 18 hrs by MTT assa... 来源：ChEMBL 靶标：Staphylococcus aureus External Id：CHEMBL2427006

实验名称：Antibacterial activity against Staphylococcus aureus XU212 after 18 hrs by MTT assay 来源：ChEMBL 靶标：Staphylococcus aureus External Id：CHEMBL2427005

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Hyperforin dicyclohexylammonium salt英文别名

• hyperforin dicyclohexylammonium salt
• Hyp-DCHA Hyperforin-DCHA
• Hyp-DCHA
• Hyperforin-DCHA