PD-1/PD-L1-IN 6

• 常用名: PD-1/PD-L1-IN 6
• 英文名: PD-1/PD-L1-IN 6
• CAS号: 2393983-76-9
• 分子量: 402.49
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₅H₂₆N₂O₃
• 熔点: N/A
• 闪点: N/A

PD-1/PD-L1-IN 6用途

PD-1/PD-L1-IN 6(化合物A13)是一种有效的PD-1/PD-L1相互作用抑制剂,IC50为132.8 纳米。PD-1/PD-L1-IN 6具有出色的免疫调节活性。在Hep3B/OS-8/hPD-L1和CD3 T细胞共培养模型中,PD-1/PD-L1-IN 6显著提高干扰素-γ的分泌,没有显著毒性作用。PD-1/PD-L1-IN 6在T细胞-肿瘤共培养模型中恢复免疫反应[1]。

PD-1/PD-L1-IN 6名称

• 英文名: PD-1/PD-L1-IN 6

PD-1/PD-L1-IN 6生物活性

• 描述: PD-1/PD-L1-IN 6(化合物A13)是一种有效的PD-1/PD-L1相互作用抑制剂,IC50为132.8 纳米。PD-1/PD-L1-IN 6具有出色的免疫调节活性。在Hep3B/OS-8/hPD-L1和CD3 T细胞共培养模型中,PD-1/PD-L1-IN 6显著提高干扰素-γ的分泌,没有显著毒性作用。PD-1/PD-L1-IN 6在T细胞-肿瘤共培养模型中恢复免疫反应[1]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 免疫及炎症 >> PD-1/PD-L1
  研究领域 >> 炎症/免疫
• 靶点实验:

  IC50: 132.8 ± 6.9 nM (PD-1/PD-L1 interaction)

• 参考文献:

  [1]. Qin M, et al. Discovery of the programmed cell death-1/programmed cell death-ligand 1 interaction inhibitors bearing an indoline scaffold. Eur J Med Chem. 2020 Jan 15;186:111856.

PD-1/PD-L1-IN 6物理化学性质

• 分子式: C₂₅H₂₆N₂O₃
• 分子量: 402.49

PD-1/PD-L1-IN 6靶点实验

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实验名称：Inhibition of PD1/PDL1 protein-protein interaction in human PBMC-derived CD3-positive... 来源：ChEMBL 靶标：Programmed cell death protein 1 External Id：CHEMBL4682315

实验名称：Inhibition of PD1/PDL1 protein-protein interaction in human PBMC-derived CD3-positive... 来源：ChEMBL 靶标：Programmed cell death protein 1 External Id：CHEMBL4682314

实验名称：Inhibition of Tag2-PD1/Tag1-PD-L1 (unknown origin) protein-protein interaction preinc... 来源：ChEMBL 靶标：Programmed cell death protein 1 External Id：CHEMBL5146067

实验名称：Inhibition of PD1/PDL1 protein-protein interaction in human PBMC-derived CD3-positive... 来源：ChEMBL 靶标：Programmed cell death protein 1 External Id：CHEMBL4682316

实验名称：Inhibition of PD1/PD-L1 (unknown origin) protein-protein interaction measured after 1... 来源：ChEMBL 靶标：Programmed cell death protein 1 External Id：CHEMBL4809423

实验名称：Inhibition of PD1/PDL1 protein-protein interaction in human PBMC-derived CD3-positive... 来源：ChEMBL 靶标：Programmed cell death protein 1 External Id：CHEMBL4809426

实验名称：Inhibition of PD-1 (unknown origin)/PD-L1 (unknown origin) interaction by HTRF bindin... 来源：ChEMBL 靶标：Programmed cell death protein 1 External Id：CHEMBL5352046

实验名称：Cytotoxicity against human Jurkat cells incubated for 48 hrs by CCK-8 assay 来源：ChEMBL 靶标：Jurkat External Id：CHEMBL4809424

实验名称：Inhibition of PD-1/PDL1 interaction (unknown origin) by HTRF assay 来源：ChEMBL 靶标：Programmed cell death protein 1 External Id：CHEMBL4682311

实验名称：Inhibition of PD1 (unknown origin)/PDL1 (unknown origin) protein-protein interaction ... 来源：ChEMBL 靶标：Programmed cell death protein 1 External Id：CHEMBL4819820

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