Anti-inflammatory agent 21

• 常用名: Anti-inflammatory agent 21
• 英文名: Anti-inflammatory agent 21
• CAS号: 2408836-40-6
• 分子量: 424.42
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₄H₂₁FO₆
• 熔点: N/A
• 闪点: N/A

Anti-inflammatory agent 21用途

抗炎剂21(化合物9o)是一种口服活性低细胞毒性抗炎剂,NO的IC50值为0.76μM。抗炎剂21通过积聚ROS发挥作用,阻断NF-κB/MAPK信号通路。抗炎剂21可以改善关节炎大鼠模型的软骨破坏和炎性细胞浸润[1]。

Anti-inflammatory agent 21名称

• 英文名: Anti-inflammatory agent 21

Anti-inflammatory agent 21生物活性

• 描述: 抗炎剂21(化合物9o)是一种口服活性低细胞毒性抗炎剂,NO的IC50值为0.76μM。抗炎剂21通过积聚ROS发挥作用,阻断NF-κB/MAPK信号通路。抗炎剂21可以改善关节炎大鼠模型的软骨破坏和炎性细胞浸润[1]。
• 相关类别:
  信号通路 >> 蛋白酪氨酸激酶 >> ROS
  信号通路 >> 免疫及炎症 >> 一氧化氮合酶
  研究领域 >> 炎症/免疫
• 靶点实验:

  IC50: 0.76 μM (NO)[1]

• 参考文献:

  [1]. Chen LZ, Wu J, Li K, et al. Novel phthalide derivatives: Synthesis and anti-inflammatory activity in vitro and in vivo. Eur J Med Chem. 2020;206:112722.

Anti-inflammatory agent 21物理化学性质

• 分子式: C₂₄H₂₁FO₆
• 分子量: 424.42

Anti-inflammatory agent 21靶点实验

查看更多实验

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实验名称：Antiarthritic activity in Sprague-Dawley rat model of arthritis assessed as reduction... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL4774020

实验名称：Antiarthritic activity in Sprague-Dawley rat model of arthritis assessed as reduction... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL4774021

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实验名称：Activation of Nrf2/HO-1 signalling pathway in mouse RAW264.7 cells assessed as inhibi... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4774011

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