COX-2-IN-27

• 常用名: COX-2-IN-27
• 英文名: COX-2-IN-27
• CAS号: 2413565-17-8
• 分子量: 602.20
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₉H₂₄ClN₇S₃
• 熔点: N/A
• 闪点: N/A

COX-2-IN-27用途

COX-2-IN-27是一种有效和选择性的COX-1抑制剂,COX-3、COX-4和15-LOX的IC50值分别为13.22、0.045和1.67µM。COX-2-IN-27具有抗炎活性[1]。

COX-2-IN-27名称

• 英文名: COX-2-IN-27

COX-2-IN-27生物活性

• 描述: COX-2-IN-27是一种有效和选择性的COX-1抑制剂,COX-3、COX-4和15-LOX的IC50值分别为13.22、0.045和1.67µM。COX-2-IN-27具有抗炎活性[1]。
• 相关类别:
  研究领域 >> 炎症/免疫
  信号通路 >> 免疫及炎症 >> COX
• 靶点实验:

  COX-1:13.22 μM (IC50)

  COX-2:0.045 μM (IC50)

  15-LOX:1.67 μM (IC50)

• 体外研究: COX-2-IN-27(化合物15b)显示出显著的COX-1选择性,SI值为293.78[1]。
• 体内研究: COX-2-IN-27(28µM/kg)在大鼠体内显示出强大的抗炎活性,在4小时和3小时内,与消炎痛相比,消肿抑制率分别为93.20%和109.08%[1]。
• 参考文献:

  [1]. Maghraby MT, et al. Novel class of benzimidazole-thiazole hybrids: The privileged scaffolds of potent anti-inflammatory activity with dual inhibition of cyclooxygenase and 15-lipoxygenase enzymes. Bioorg Med Chem. 2020 Apr 1;28(7):115403.

COX-2-IN-27物理化学性质

• 分子式: C₂₉H₂₄ClN₇S₃
• 分子量: 602.20
• InChIKey: VVGDOFKPSNGUQP-QBSJXOACSA-N
• SMILES: CSc1nc2ccccc2n1-c1csc(NCC(C)=NN=c2scc(-c3ccc(Cl)cc3)n2-c2ccccc2)n1

COX-2-IN-27靶点实验

查看更多实验

实验名称：Antiinflammatory activity in albino rat assessed as reduction in carrageenan-induced ... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL4628542

实验名称：Anti-inflammatory activity in albino rat assessed as inhibition of carrageenan-induce... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL4628545

实验名称：Anti-inflammatory activity in albino rat assessed as inhibition of carrageenan-induce... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL4628546

实验名称：Anti-inflammatory activity in albino rat assessed as inhibition of carrageenan-induce... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL4628535

实验名称：Anti-inflammatory activity in albino rat assessed as inhibition of carrageenan-induce... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL4628534

实验名称：Antiinflammatory activity in albino rat assessed as reduction in carrageenan-induced ... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL4628537

实验名称：Anti-inflammatory activity in albino rat assessed as inhibition of carrageenan-induce... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL4628536

实验名称：Antiinflammatory activity in albino rat assessed as reduction in carrageenan-induced ... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL4628539

实验名称：Antiinflammatory activity in albino rat assessed as reduction in carrageenan-induced ... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL4628538

实验名称：Antiinflammatory activity in albino rat assessed as reduction in carrageenan-induced ... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL4628541

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