HBV-IN-23

• 常用名: HBV-IN-23
• 英文名: HBV-IN-23
• CAS号: 2413649-89-3
• 分子量: 449.57
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₅H₂₇N₃O₃S
• 熔点: N/A
• 闪点: N/A

HBV-IN-23用途

HBV-IN-23(化合物5k)是一种HBV DNA复制抑制剂,IC50为0.58µM。HBV-IN-23抑制药物敏感和耐药HBV株中的HBV DNA复制。HBV-IN-23显示抗肝细胞癌细胞(HCC)活性。HBV-IN-23诱导HepG2细胞凋亡[1]。

HBV-IN-23名称

• 英文名: HBV-IN-23

HBV-IN-23生物活性

• 描述: HBV-IN-23(化合物5k)是一种HBV DNA复制抑制剂,IC50为0.58µM。HBV-IN-23抑制药物敏感和耐药HBV株中的HBV DNA复制。HBV-IN-23显示抗肝细胞癌细胞(HCC)活性。HBV-IN-23诱导HepG2细胞凋亡[1]。
• 相关类别:
  信号通路 >> 细胞凋亡 >> 细胞凋亡
  研究领域 >> 癌症
  研究领域 >> 感染
  信号通路 >> 抗感染 >> HBV
  信号通路 >> 细胞周期/DNA损伤 >> DNA/RNA合成
• 靶点实验:

  IC50: 0.58 µM (HBV DNA replication)[1]

• 参考文献:

  [1]. Qiu J, et al. Discovery of novel quinazolinone derivatives as potential anti-HBV and anti-HCC agents. Eur J Med Chem. 2020 Nov 1;205:112581.

HBV-IN-23物理化学性质

• 分子式: C₂₅H₂₇N₃O₃S
• 分子量: 449.57

HBV-IN-23靶点实验

查看更多实验

实验名称：Antiviral activity against lamivudine and entecavir-resistant HBV harboring rtL180 M/... 来源：ChEMBL 靶标：Hepatitis B virus External Id：CHEMBL4773504

实验名称：Antiproliferative activity against human HepG2 cells assessed as inhibition of cell p... 来源：ChEMBL 靶标：HepG2 External Id：CHEMBL4773505

实验名称：Induction of apoptosis in human HepG2 cells assessed as viable cells at 5 uM after 48... 来源：ChEMBL 靶标：HepG2 External Id：CHEMBL4773510

实验名称：Induction of apoptosis in human HepG2 cells assessed as early apoptotic cells at 5 uM... 来源：ChEMBL 靶标：HepG2 External Id：CHEMBL4773511

实验名称：Induction of apoptosis in human HepG2 cells assessed as nuclear fragmentation at 5 to... 来源：ChEMBL 靶标：HepG2 External Id：CHEMBL4773508

实验名称：Induction of apoptosis in human HepG2 cells assessed as chromatin condensation at 5 t... 来源：ChEMBL 靶标：HepG2 External Id：CHEMBL4773509

实验名称：Selectivity index, ratio of CC50 for human HepG2 2.2.15 cells to IC50 for antiviral a... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4773498

实验名称：Antiviral activity against HBV infected in human HepG2.2.15 cells assessed as inhibit... 来源：ChEMBL 靶标：Hepatitis B virus External Id：CHEMBL4773499

实验名称：Antiviral activity against HBV infected in human HepG2.2.15 cells assessed as inhibit... 来源：ChEMBL 靶标：Hepatitis B virus External Id：CHEMBL4773496

实验名称：Antiviral activity against HBV infected in human HepG2.2.15 cells assessed as inhibit... 来源：ChEMBL 靶标：Hepatitis B virus External Id：CHEMBL4773497

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