JH-XII-03-02

• 常用名: JH-XII-03-02
• 英文名: JH-XII-03-02
• CAS号: 2415900-86-4
• 分子量: 853.92
• 密度: N/A
• 沸点: N/A
• 分子式: C₄₃H₅₁N₉O₁₀
• 熔点: N/A
• 闪点: N/A

JH-XII-03-02用途

JH-XII-03-02是一种有效的选择性LRRK2 PROTAC降解剂。JH-XII-03-02可用于帕金森研究。

JH-XII-03-02名称

• 英文名: JH-XII-03-02

JH-XII-03-02生物活性

• 描述: JH-XII-03-02是一种有效的选择性LRRK2 PROTAC降解剂。JH-XII-03-02可用于帕金森研究。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 自噬 >> LRRK2
  信号通路 >> 蛋白裂解靶向嵌合体 >> PROTAC
• 参考文献:

  [1]. John M Hatcher, et al. Development of a highly potent and selective degrader of LRRK2. Bioorg Med Chem Lett. 2023 Oct 1;94:129449.

JH-XII-03-02物理化学性质

• 分子式: C₄₃H₅₁N₉O₁₀
• 分子量: 853.92
• InChIKey: XYGRYBJBOSXMHE-UHFFFAOYSA-N
• SMILES: CC1(Oc2ccc3[nH]nc(-c4cc(N5CCN(C(=O)CCOCCOCCOCCOCCNc6cccc7c6C(=O)N(C6CCC(=O)NC6=O)C7=O)CC5)ncn4)c3c2)CC1

JH-XII-03-02靶点实验

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实验名称：Inhibition of LRRK2 in MEF cells assessed as reduction in Rab10 phosphorylation at 10... 来源：ChEMBL 靶标：Leucine-rich repeat serine/threonine-protein kinase 2 External Id：CHEMBL5366305

实验名称：Inhibition of human partial length LRRK2 G2019S mutant (H970 to E2527 residues) expre... 来源：ChEMBL 靶标：Leucine-rich repeat serine/threonine-protein kinase 2 External Id：CHEMBL5366306

实验名称：Protac activity at CRBN/GAK in LRRK2 knockout MEF cells assessed as induction of GAK ... 来源：ChEMBL 靶标：Cyclin-G-associated kinase External Id：CHEMBL5366303

实验名称：Inhibition of LRRK2 in MEF cells assessed as reduction in pS935 phosphorylation at 10... 来源：ChEMBL 靶标：Leucine-rich repeat serine/threonine-protein kinase 2 External Id：CHEMBL5366304

实验名称：Protac activity at CRBN/GAK in MEF cells assessed as induction of GAK degradation at ... 来源：ChEMBL 靶标：Cyclin-G-associated kinase External Id：CHEMBL5366301

实验名称：Protac activity at CRBN/ZFP91 in human MOLT-4 cells assessed as induction of ZFP91 de... 来源：ChEMBL 靶标：Protein cereblon External Id：CHEMBL5366299

实验名称：Protac activity at CRBN/GAK in human MOLT-4 cells assessed as induction of GAK degrad... 来源：ChEMBL 靶标：Protein cereblon External Id：CHEMBL5366300

实验名称：Protac activity at CRBN/IKZF1 in human MOLT-4 cells assessed as induction of IKZF1 de... 来源：ChEMBL 靶标：Protein cereblon External Id：CHEMBL5366297

实验名称：Protac activity at CRBN/IKZF3 in human MOLT-4 cells assessed as induction of IKZF3 de... 来源：ChEMBL 靶标：Zinc finger protein Aiolos External Id：CHEMBL5366298

实验名称：Protac activity at CRBN/LRRK2 in human MOLT-4 cells assessed as induction of LRRK2 de... 来源：ChEMBL 靶标：Leucine-rich repeat serine/threonine-protein kinase 2 External Id：CHEMBL5366296

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