HDAC3/6-IN-2

• 常用名: HDAC3/6-IN-2
• 英文名: HDAC3/6-IN-2
• CAS号: 2417510-17-7
• 分子量: 822.09
• 密度: N/A
• 沸点: N/A
• 分子式: C₄₉H₆₇N₅O₆
• 熔点: N/A
• 闪点: N/A

HDAC3/6-IN-2用途

HDAC3/6-IN-2(化合物15)是一种有效的HDAC6和HDAC3抑制剂,IC50值分别为0.368和0.635μM。HDAC3/6-IN-2具有抗肿瘤活性,可诱导癌细胞凋亡。HDAC3/6-IN-2降低HDAC6和HDAC3的水平,与乙酰化H3和α-微管蛋白的上调相关[1]。

HDAC3/6-IN-2名称

• 英文名: HDAC3/6-IN-2

HDAC3/6-IN-2生物活性

• 描述: HDAC3/6-IN-2(化合物15)是一种有效的HDAC6和HDAC3抑制剂,IC50值分别为0.368和0.635μM。HDAC3/6-IN-2具有抗肿瘤活性,可诱导癌细胞凋亡。HDAC3/6-IN-2降低HDAC6和HDAC3的水平,与乙酰化H3和α-微管蛋白的上调相关[1]。
• 相关类别:
  信号通路 >> 细胞凋亡 >> 细胞凋亡
  研究领域 >> 癌症
  信号通路 >> 细胞周期/DNA损伤 >> HDAC
  信号通路 >> 表观遗传学 >> HDAC
• 靶点实验:

  HDAC6:0.368 μM (IC50)

  HDAC3:0.635 μM (IC50)

  HDAC1:2.512 μM (IC50)

  HDAC2:4.830 μM (IC50)

• 参考文献:

  [1]. Huang M, Xie X, Gong P, et al. A 18β-glycyrrhetinic acid conjugate with Vorinostat degrades HDAC3 and HDAC6 with improved antitumor effects. Eur J Med Chem. 2020;188:111991.

HDAC3/6-IN-2物理化学性质

• 分子式: C₄₉H₆₇N₅O₆
• 分子量: 822.09

HDAC3/6-IN-2靶点实验

查看更多实验

实验名称：Induction of apoptosis in human HL-60 cells assessed as increase in accumulation at s... 来源：ChEMBL 靶标：HL-60 External Id：CHEMBL4683037

实验名称：Induction of apoptosis in human HL-60 cells assessed as increase in accumulation at s... 来源：ChEMBL 靶标：HL-60 External Id：CHEMBL4683039

实验名称：Induction of apoptosis in human HL-60 cells assessed as increase in accumulation at s... 来源：ChEMBL 靶标：HL-60 External Id：CHEMBL4683038

实验名称：Induction of apoptosis in human HL-60 cells assessed as early apoptotic cells at 0.5 ... 来源：ChEMBL 靶标：HL-60 External Id：CHEMBL4683041

实验名称：Induction of apoptosis in human HL-60 cells assessed as live cells at 0.5 uM measured... 来源：ChEMBL 靶标：HL-60 External Id：CHEMBL4683040

实验名称：AUC (0 to infinity) in Sprague-Dawley rat at 5 mg/kg, iv measured up to 24 hrs by LC-... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4683059

实验名称：Cytotoxicity against human PC-3 cells assessed as reduction in cell viability after 9... 来源：ChEMBL 靶标：PC-3 External Id：CHEMBL4683031

实验名称：Antiproliferative activity against human HL-60 cells assessed as cell growth inhibiti... 来源：ChEMBL 靶标：HL-60 External Id：CHEMBL4683032

实验名称：Induction of apoptosis in human HL-60 cells assessed as necrotic cells at 2 uM measur... 来源：ChEMBL 靶标：HL-60 External Id：CHEMBL4683051

实验名称：Induction of apoptosis in human HL-60 cells assessed as late apoptotic cells at 2 uM ... 来源：ChEMBL 靶标：HL-60 External Id：CHEMBL4683050

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