PROTAC EZH2 Degrader-1

• 常用名: PROTAC EZH2 Degrader-1
• 英文名: PROTAC EZH2 Degrader-1
• CAS号: 2641601-67-2
• 分子量: 942.15
• 密度: N/A
• 沸点: N/A
• 分子式: C₅₄H₆₇N₇O₈
• 熔点: N/A
• 闪点: N/A

PROTAC EZH2 Degrader-1用途

PROTAC EZH2降解剂-1(化合物150d)是一种有效的PROTAC AZH2分解剂,其IC50为2.7nM,对EZH2甲基转移酶活性具有抑制作用。EZH2在许多肿瘤的发生和发展过程中起着重要作用[1]。

PROTAC EZH2 Degrader-1名称

• 英文名: PROTAC EZH2 Degrader-1

PROTAC EZH2 Degrader-1生物活性

• 描述: PROTAC EZH2降解剂-1(化合物150d)是一种有效的PROTAC AZH2分解剂,其IC50为2.7nM,对EZH2甲基转移酶活性具有抑制作用。EZH2在许多肿瘤的发生和发展过程中起着重要作用[1]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 表观遗传学 >> 组蛋白甲基转移酶
  信号通路 >> 蛋白裂解靶向嵌合体 >> PROTAC
• 靶点实验:

  EZH2:2.7 nM (IC50)

• 参考文献:

  [1]. Juan Xia, et al. Targeting Enhancer of Zeste Homolog 2 for the Treatment of Hematological Malignancies and Solid Tumors: Candidate Structure-Activity Relationships Insights and Evolution Prospects. J Med Chem. 2022 May 26;65(10):7016-7043.

PROTAC EZH2 Degrader-1物理化学性质

• 分子式: C₅₄H₆₇N₇O₈
• 分子量: 942.15

PROTAC EZH2 Degrader-1靶点实验

查看更多实验

实验名称：PROTAC activity at CRBN E3 ligase/EZH2 in PRC2 complex in human WSUDLCL2 cells assess... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5039024

实验名称：PROTAC activity at CRBN E3 ligase/EZH2 in PRC2 complex in human WSUDLCL2 cells assess... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5039023

实验名称：Binding affinity to SUZ12 in human WSUDLCL2 cells assessed as thermal stability by me... 来源：ChEMBL 靶标：Polycomb protein SUZ12 External Id：CHEMBL5039022

实验名称：Binding affinity to EED in human WSUDLCL2 cells assessed as thermal stability by meas... 来源：ChEMBL 靶标：Polycomb protein EED External Id：CHEMBL5039021

实验名称：PROTAC activity at CRBN E3 ligase/EZH2 in PRC2 complex in human WSUDLCL2 cells assess... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5039028

实验名称：PROTAC activity at CRBN E3 ligase/EZH2 in PRC2 complex in human WSUDLCL2 cells assess... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5039027

实验名称：PROTAC activity at CRBN E3 ligase/EZH2 in PRC2 complex in human WSUDLCL2 cells assess... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5039026

实验名称：PROTAC activity at CRBN E3 ligase/EZH2 in PRC2 complex in human WSUDLCL2 cells assess... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5039025

实验名称：Inhibition of N-terminal His-tagged EZH2 in human PRC2 complex (2 to end residues) ex... 来源：ChEMBL 靶标：Histone-lysine N-methyltransferase EZH2 External Id：CHEMBL5039016

实验名称：Antiproliferative activity against human WSUDLCL2 cells harboring EZH2-Y641F mutant a... 来源：ChEMBL 靶标：WSUDLCL2 External Id：CHEMBL5039020

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