Tubulin polymerization-IN-56

• 常用名: Tubulin polymerization-IN-56
• 英文名: Tubulin polymerization-IN-56
• CAS号: 2966790-98-5
• 分子量: 411.88
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₂H₂₂ClN₃O₃
• 熔点: N/A
• 闪点: N/A

Tubulin polymerization-IN-56用途

Tubulin polymerization-IN-56 (compound 8l) 是一种吲唑衍生物,是一种有效的微管蛋白聚合抑制剂,通过与秋水仙碱位点相互作用,导致细胞周期停滞和细胞凋亡。Tubulin polymerization-IN-56 可减少细胞迁移并更有效地抑制体内肿瘤生长。

Tubulin polymerization-IN-56名称

• 英文名: Tubulin polymerization-IN-56

Tubulin polymerization-IN-56生物活性

• 描述: Tubulin polymerization-IN-56 (compound 8l) 是一种吲唑衍生物,是一种有效的微管蛋白聚合抑制剂,通过与秋水仙碱位点相互作用,导致细胞周期停滞和细胞凋亡。Tubulin polymerization-IN-56 可减少细胞迁移并更有效地抑制体内肿瘤生长。
• 相关类别:
  信号通路 >> 细胞凋亡 >> 细胞凋亡
  研究领域 >> 癌症
  信号通路 >> 细胞周期/DNA损伤 >> 微管/微管蛋白
  信号通路 >> 细胞骨架 >> 微管/微管蛋白
• 参考文献:

  [1]. Ying-Jie Cui, et al. The discovery of water-soluble indazole derivatives as potent microtubule polymerization inhibitors. Eur J Med Chem. 2023 Oct 18:262:115870.

Tubulin polymerization-IN-56物理化学性质

• 分子式: C₂₂H₂₂ClN₃O₃
• 分子量: 411.88

Tubulin polymerization-IN-56靶点实验

查看更多实验

实验名称：Antiproliferative activity against human Huh-7 cells assessed as cell growth inhibiti... 来源：ChEMBL 靶标：Huh-7 External Id：CHEMBL5637982

实验名称：Antiproliferative activity against human T-24 cells assessed as cell growth inhibitio... 来源：ChEMBL 靶标：T-24 External Id：CHEMBL5637983

实验名称：Resistance index, ratio of IC50 for human A549/Taxol cells to IC50 for human A549 cel... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5637985

实验名称：Aqueous solubility of compound in pH 7.4 at 10 mg/ml by HPLC analysis 来源：ChEMBL 靶标：N/A External Id：CHEMBL5637986

实验名称：Lipophilicity, logP of compound in n-octanol-water at 5 mg/ml incubated for 8 hrs by ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5637987

实验名称：Inhibition of pig brain tubulin polymerization by absorbance based assay 来源：ChEMBL 靶标：N/A External Id：CHEMBL5637988

实验名称：Inhibition of tubulin polymerization in human A549 cells assessed as disruption of mi... 来源：ChEMBL 靶标：Tubulin alpha-3C chain External Id：CHEMBL5637991

实验名称：Inhibition of tubulin polymerization in human A549 cells assessed as decrease in spin... 来源：ChEMBL 靶标：Tubulin alpha-3C chain External Id：CHEMBL5637992

实验名称：Binding affinity to tubulin polymerization in human A549 cells assessed as N,N'-ethyl... 来源：ChEMBL 靶标：Tubulin alpha-3C chain External Id：CHEMBL5637993

实验名称：Binding affinity to tubulin polymerization at colchicine-binding site in human A549 c... 来源：ChEMBL 靶标：Tubulin alpha-3C chain External Id：CHEMBL5637994

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