去氧土大黄苷

• 常用名: 去氧土大黄苷
• 英文名: Desoxyrhaponticin
• CAS号: 30197-14-9
• 分子量: 404.410
• 密度: 1.4±0.1 g/cm3
• 沸点: 700.5±60.0 °C at 760 mmHg
• 分子式: C₂₁H₂₄O₈
• 熔点: N/A
• 闪点: 377.5±32.9 °C

去氧土大黄苷用途

Desoxyrhaponticin 是一种来自西藏营养食品 Rheum tanguticum Maxim 的二苯乙烯苷。Desoxyrhaponticin 是一种脂肪酸合成酶 (FAS) 抑制剂,对人类癌细胞具有凋亡作用。

去氧土大黄苷名称

• 中文名: 脱氧土大黄苷
• 英文名: 2-[3-hydroxy-5-[(E)-2-(4-methoxyphenyl)ethenyl]phenoxy]-6-(hydroxymethyl)oxane-3,4,5-triol
• 中文别名: 甲基虎杖苷 | 去氧土大黄苷

去氧土大黄苷生物活性

• 描述: Desoxyrhaponticin 是一种来自西藏营养食品 Rheum tanguticum Maxim 的二苯乙烯苷。Desoxyrhaponticin 是一种脂肪酸合成酶 (FAS) 抑制剂,对人类癌细胞具有凋亡作用。
• 相关类别:
  信号通路 >> 细胞凋亡 >> 细胞凋亡
  研究领域 >> 癌症
  信号通路 >> 代谢酶/蛋白酶 >> 脂肪酸合成酶(FAS)
• 参考文献:

  [1]. Li P, et al. Inhibitory effect of desoxyrhaponticin and rhaponticin, two natural stilbene glycosides from the Tibetan nutritional food Rheum tanguticum Maxim. ex Balf., on fatty acid synthase and human breast cancer cells.

去氧土大黄苷物理化学性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 700.5±60.0 °C at 760 mmHg
• 分子式: C₂₁H₂₄O₈
• 分子量: 404.410
• 闪点: 377.5±32.9 °C
• 精确质量: 404.147125
• PSA: 128.84000
• LogP: 1.48
• InChIKey: MFMQRDLLSRLUJY-DXKBKAGUSA-N
• SMILES: COc1ccc(C=Cc2cc(O)cc(OC3OC(CO)C(O)C(O)C3O)c2)cc1
• 蒸汽压: 0.0±2.3 mmHg at 25°C
• 折射率: 1.691
• 储存条件: 2-8°C

去氧土大黄苷安全信息

• WGK德国: 3

去氧土大黄苷靶点实验

查看更多实验

实验名称：Inhibition of adenosine diphosphate-induced platelet aggregation in human platelet-ri... 来源：ChEMBL 靶标：Platelet External Id：CHEMBL992905

实验名称：Compound (at 100 uM) was tested for inhibition against nitric oxide production in LPS... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL734835

实验名称：Primary Screen Inhibitors of CD40 Signaling in BL2 Cells Measured in Cell-Based Syste... 来源：Broad Institute 靶标：N/A External Id：7124-01_Inhibitor_SinglePoint_HTS_Activity

实验名称：Inhibition of collagen-induced platelet aggregation in human platelet-rich plasma 来源：ChEMBL 靶标：Platelet External Id：CHEMBL992004

实验名称：EZH2/PRC2 methyltransferase inhibitors Measured in Biochemical System Using Plate Rea... 来源：Broad Institute 靶标：histone-lysine N-methyltransferase EZH2 isoform a [Homo sapiens] External Id：2125-01_Inhibitor_SinglePoint_HTS_Activity

实验名称：Screen for inhibitors of RMI FANCM (MM2) intereaction 来源：11908 靶标：N/A External Id：RMI-FANCM-MM2

实验名称：Inhibitory activity against nitric oxide production in LPS-activated mouse peritoneal... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL739443

实验名称：Estrogenic activity at ERalpha/ERbeta (unknown origin) expressed in human HepG2 cells... 来源：ChEMBL 靶标：Estrogen receptor beta External Id：CHEMBL4188356

实验名称：Molluscicidal activity against Biomphalaria glabrata at 200 ppm 来源：ChEMBL 靶标：Biomphalaria glabrata External Id：CHEMBL1011267

实验名称：Estrogenic activity at ERalpha/ERbeta (unknown origin) expressed in human HepG2 cells... 来源：ChEMBL 靶标：Estrogen receptor beta External Id：CHEMBL4188357

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去氧土大黄苷英文别名

• Desoxyrhaponticin
• 3-hydroxy-5-[(E)-2-(4-methoxyphenyl)ethenyl]phenyl β-D-glucopyranoside
• Deoxyrhapontin from rhubarb root
• 3,5-Dihydroxy-4 inverted exclamation marka-methoxystilbene 3-O-|A-D-glucoside
• 3-Hydroxy-5-[(E)-2-(4-methoxyphenyl)vinyl]phenyl β-D-glucopyranoside
• Deoxyrhapontin
• β-D-Glucopyranoside, 3-hydroxy-5-[(E)-2-(4-methoxyphenyl)ethenyl]phenyl