Sideroxylin

• 常用名: Sideroxylin
• 英文名: Sideroxylin
• CAS号: 3122-87-0
• 分子量: 312.317
• 密度: 1.3±0.1 g/cm3
• 沸点: 565.5±50.0 °C at 760 mmHg
• 分子式: C₁₈H₁₆O₅
• 熔点: N/A
• 闪点: 210.3±23.6 °C

Sideroxylin用途

Sideroxylin 是一种从 Callistemon lanceolatus 中分离的 C-甲基化黄酮,对金黄色葡萄球菌具有抗菌活性。Sideroxylin 可抑制卵巢癌细胞增殖并诱导凋亡 (apoptosis),导致 DNA 断裂,线粒体膜去极化,产生活性氧 (ROS)。

Sideroxylin名称

• 中文名: 4',5-二羟基-7-甲氧基-6,8-二甲基黄酮
• 英文名: 5-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-6,8-dimethylchromen-4-one

Sideroxylin生物活性

• 描述: Sideroxylin 是一种从 Callistemon lanceolatus 中分离的 C-甲基化黄酮,对金黄色葡萄球菌具有抗菌活性。Sideroxylin 可抑制卵巢癌细胞增殖并诱导凋亡 (apoptosis),导致 DNA 断裂,线粒体膜去极化,产生活性氧 (ROS)。
• 相关类别:
  信号通路 >> 细胞凋亡 >> 细胞凋亡
  研究领域 >> 癌症
  研究领域 >> 感染
  信号通路 >> 抗感染 >> 细菌
• 参考文献:

  [1]. Sunwoo Park, et al. Sideroxylin (Callistemon Lanceolatus) Suppressed Cell Proliferation and Increased Apoptosis in Ovarian Cancer Cells Accompanied by Mitochondrial Dysfunction, the Generation of Reactive Oxygen Species, and an Increase of Lipid Peroxidation. J Cell Physiol. 2018 Nov;233(11):8597-8604.

Sideroxylin物理化学性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 565.5±50.0 °C at 760 mmHg
• 分子式: C₁₈H₁₆O₅
• 分子量: 312.317
• 闪点: 210.3±23.6 °C
• 精确质量: 312.099762
• PSA: 79.90000
• LogP: 3.28
• InChIKey: QJSQOGJCHBXLAH-UHFFFAOYSA-N
• SMILES: COc1c(C)c(O)c2c(=O)cc(-c3ccc(O)cc3)oc2c1C
• 外观性状: 黄色粉末
• 蒸汽压: 0.0±1.6 mmHg at 25°C
• 折射率: 1.644
• 储存条件: 2-8℃，干燥，密闭

Sideroxylin安全信息

• 危害码 (欧洲): Xi
• 海关编码: 2914509090

Sideroxylin海关

• 海关编码: 2914509090
• 中文概述: 2914509090 含其他含氧基的酮. 增值税率:17.0% 退税率:9.0% 监管条件:无 最惠国关税:5.5% 普通关税:30.0%
• 申报要素: 品名, 成分含量, 用途, 丙酮报明包装
• Summary: HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

Sideroxylin靶点实验

查看更多实验

实验名称：Inhibition of biotinylated consensus sequence binding to NF-kB p65 in human HeLa nucl... 来源：ChEMBL 靶标：Transcription factor p65 External Id：CHEMBL4235015

实验名称：Cytotoxicity against human OVCAR3 cells assessed as reduction in cell viability after... 来源：ChEMBL 靶标：OVCAR-3 External Id：CHEMBL4235014

实验名称：Inhibition of mitochondrial membrane potential in human HT-29 cells after 3 hrs by JC... 来源：ChEMBL 靶标：HT-29 External Id：CHEMBL4235016

实验名称：Antibacterial activity against Escherichia coli after 24 hrs by broth microdilution m... 来源：ChEMBL 靶标：Escherichia coli External Id：CHEMBL4180038

实验名称：Antibacterial activity against Pseudomonas aeruginosa after 24 hrs by broth microdilu... 来源：ChEMBL 靶标：Pseudomonas aeruginosa External Id：CHEMBL4180039

实验名称：Inhibition of Staphylococcus aureus K1758 NorA mutant assessed as inhibition of ethid... 来源：ChEMBL 靶标：N/A External Id：CHEMBL1819803

实验名称：Antibacterial activity against Shigella flexneri after 24 hrs by broth microdilution ... 来源：ChEMBL 靶标：Shigella flexneri External Id：CHEMBL4180040

实验名称：Inhibition of wild type Staphylococcus aureus NCTC8325-4 NorA assessed as time taken ... 来源：ChEMBL 靶标：Quinolone resistance protein NorA External Id：CHEMBL1819802

实验名称：Antifeedant activity against Locusta migratoria final stadium nymphs at 100 ppm by gl... 来源：ChEMBL 靶标：Locusta migratoria External Id：CHEMBL3081538

实验名称：Antifeedant activity against Spodoptera exigua final stadium nymphs at 100 ppm by gla... 来源：ChEMBL 靶标：Spodoptera exigua External Id：CHEMBL3081539

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Sideroxylin英文别名

• 4',5-Dihydroxy-7-methoxy-6,8-dimethylflavone
• 5-Hydroxy-2-(4-hydroxyphenyl)-7-methoxy-6,8-dimethyl-4H-chromen-4-one
• 5,4'-dihydroxy-7-methoxy-6,8-dimethylflavone
• sideroxyline
• 5-Hydroxy-2-(4-hydroxyphenyl)-7-methoxy-6,8-dimethyl-4H-1-benzopyran-4-one
• sideroxylin