美迪紫檀素

• 常用名: 美迪紫檀素
• 英文名: Medicarpin
• CAS号: 32383-76-9
• 分子量: 270.280
• 密度: 1.3±0.1 g/cm3
• 沸点: 418.8±45.0 °C at 760 mmHg
• 分子式: C₁₆H₁₄O₄
• 熔点: 127.5-128.5°
• 闪点: 207.1±28.7 °C

美迪紫檀素用途

Medicarpin 是一种从紫花苜蓿中分离出的类黄酮。Medicarpin 通过调节 P-gp 介导的药物外流,诱导白血病 P388 细胞凋亡 (apoptosis) 并克服多药耐药性。

美迪紫檀素名称

• 中文名: 美迪紫檀素
• 英文名: (-)-medicarpin

美迪紫檀素生物活性

• 描述: Medicarpin 是一种从紫花苜蓿中分离出的类黄酮。Medicarpin 通过调节 P-gp 介导的药物外流,诱导白血病 P388 细胞凋亡 (apoptosis) 并克服多药耐药性。
• 相关类别:
  信号通路 >> 细胞凋亡 >> 细胞凋亡
  研究领域 >> 癌症
• 体外研究: Medicarpin(90µM；48h)可诱导敏感和多药耐药P388细胞凋亡。表达P-糖蛋白的P388/DOX细胞对苜蓿红素没有耐药性(P388和P388/DOX细胞的IC50≈90µM)[1]。
• 参考文献:

  [1]. Grégory Gatouillat, et al. Medicarpin and millepurpan, two flavonoids isolated from Medicago sativa, induce apoptosis and overcome multidrug resistance in leukemia P388 cells. medicine. 2015 Dec 1;22(13):1186-94.

美迪紫檀素物理化学性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 418.8±45.0 °C at 760 mmHg
• 熔点: 127.5-128.5°
• 分子式: C₁₆H₁₄O₄
• 分子量: 270.280
• 闪点: 207.1±28.7 °C
• 精确质量: 270.089203
• PSA: 47.92000
• LogP: 2.72
• InChIKey: NSRJSISNDPOJOP-BBRMVZONSA-N
• SMILES: COc1ccc2c(c1)OC1c3ccc(O)cc3OCC21
• 外观性状: 粉末
• 蒸汽压: 0.0±1.0 mmHg at 25°C
• 折射率: 1.630
• 储存条件: 2-8℃，干燥，密闭

美迪紫檀素安全信息

• 危害码 (欧洲): Xi

美迪紫檀素靶点实验

查看更多实验

实验名称：Primary cell-based high-throughput screening assay for identification of compounds th... 来源：Johns Hopkins Ion Channel Center 靶标：regulator of G-protein signaling 4 isoform 2 [Homo sapiens] External Id：JHICC_RGS_Act_HTS

实验名称：Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induc... 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL2399681

实验名称：Luminescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：mu-type opioid receptor isoform MOR-1 [Homo sapiens] External Id：OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN

实验名称：QFRET-based biochemical primary high throughput screening assay to identify exosite i... 来源：The Scripps Research Institute Molecular Screening Center 靶标：disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] External Id：ADAM17_INH_QFRET_1536_1X%INH PRUN

实验名称：Cytotoxicity against mouse RAW264.7 cells by CCK assay 来源：ChEMBL 靶标：N/A External Id：CHEMBL2399680

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：uHTS identification of small molecule activators of the adaptive arm of the Unfolded ... 来源：Burnham Center for Chemical Genomics 靶标：N/A External Id：BCCG-A405-UPR-XBP1-PrimaryAgonist-Assay

实验名称：Antibacterial activity against Klebsiella pneumoniae MDR ATCC 70063 (CO-ADD:GN_003); ... 来源：ChEMBL 靶标：Klebsiella pneumoniae External Id：CHEMBL4296186

实验名称：Fluorescence polarization to screen for inhibitor that competite the binding of FadD2... 来源：Broad Institute 靶标：FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE) External Id：2147-01_Inhibitor_SinglePoint_HTS_Activity

实验名称：Primary Screen Inhibitors of CD40 Signaling in BL2 Cells Measured in Cell-Based Syste... 来源：Broad Institute 靶标：N/A External Id：7124-01_Inhibitor_SinglePoint_HTS_Activity

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美迪紫檀素英文别名

• l-3-Hydroxy-9-methoxypterocarpan
• UNII-6TX086I6IG
• (-)-3-Hydroxy-9-methoxypterocarpan
• 3-hydroxy-9-methoxypterocarpan
• Demethylhomopterocarpin
• Medicarpin
• (6aR-cis)-6a,11a-Dihydro-9-methoxy-6H-benzofuro[3,2-c][1]benzopyran-3-ol
• (6aR,11aR)-9-Methoxy-6a,11a-dihydro-6H-[1]benzofuro[3,2-c]chromen-3-ol
• demethylhomopterocarpan