5-METHYL-2-[(1R,6R)-3-METHYL-6-(1-METHYLETHENYL)-2-CYCLOHEXEN-1-YL]-1,3-BENZENEDIOL

• 常用名: 5-METHYL-2-[(1R,6R)-3-METHYL-6-(1-METHYLETHENYL)-2-CYCLOHEXEN-1-YL]-1,3-BENZENEDIOL
• 英文名: 5-METHYL-2-[(1R,6R)-3-METHYL-6-(1-METHYLETHENYL)-2-CYCLOHEXEN-1-YL]-1,3-BENZENEDIOL
• CAS号: 35482-50-9
• 分子量: 258.355
• 密度: 1.1±0.1 g/cm3
• 沸点: 414.3±45.0 °C at 760 mmHg
• 分子式: C₁₇H₂₂O₂
• 熔点: N/A
• 闪点: 192.3±23.3 °C

用途

Cannabidiorcol (CBDO、CBD-C1、O-1821) 与大麻二酚的衍生物,其戊基侧链缩短为甲基。 Cannabidiorcol 对大麻素受体 (CB) 的亲和力较低,是瞬时受体电位通道 (TRP channel) 的激动剂,通过该通道产生抗炎作用,但高浓度时还可促进肿瘤发生。

名称

• 英文名: 5-methyl-2-[(6R)-3-methyl-6-prop-1-en-2-ylcyclohex-2-en-1-yl]benzene-1,3-diol

生物活性

• 描述: Cannabidiorcol (CBDO、CBD-C1、O-1821) 与大麻二酚的衍生物,其戊基侧链缩短为甲基。 Cannabidiorcol 对大麻素受体 (CB) 的亲和力较低,是瞬时受体电位通道 (TRP channel) 的激动剂,通过该通道产生抗炎作用,但高浓度时还可促进肿瘤发生。
• 相关类别:
  信号通路 >> 跨膜转运 >> TRP频道
  研究领域 >> 癌症
  研究领域 >> 炎症/免疫
• 靶点实验:

  AChE:4.61 mM (Ki)

• 参考文献:

  [1]. Teresina Laragione, et al. Combination therapy of a TRPV2 agonist with a TNF inhibitor achieves sustained suppression of disease severity and reduced joint damage. Clin Exp Immunol. 2023 Mar; 211(3): 233–238.

  [2]. Rongqi Huang, et al. Thermal stress involved in TRPV2 promotes tumorigenesis through the pathways of HSP70/27 and PI3K/Akt/mTOR in esophageal squamous cell carcinoma. Br J Cancer. 2022 Nov 1; 127(8): 1424–1439.

物理化学性质

• 密度: 1.1±0.1 g/cm3
• 沸点: 414.3±45.0 °C at 760 mmHg
• 分子式: C₁₇H₂₂O₂
• 分子量: 258.355
• 闪点: 192.3±23.3 °C
• 精确质量: 258.161987
• PSA: 40.46000
• LogP: 4.91
• InChIKey: GKVOVXWEBSQJPA-UONOGXRCSA-N
• SMILES: C=C(C)C1CCC(C)=CC1c1c(O)cc(C)cc1O
• 蒸汽压: 0.0±1.0 mmHg at 25°C
• 折射率: 1.565
• 储存条件: -20°C，密闭，干燥

靶点实验

查看更多实验

实验名称：Agonist activity at human CB2 receptor expressed in CHO cells assessed as forskolin-s... 来源：ChEMBL 靶标：Cannabinoid receptor 2 External Id：CHEMBL5529047

实验名称：Antagonist activity at human CB1 receptor expressed in CHO cells assessed as inhibiti... 来源：ChEMBL 靶标：Cannabinoid receptor 1 External Id：CHEMBL5529046

实验名称：Discovery of Small Molecules to Inhibit Human Cytomegalovirus Nuclear Egress 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：HCMV UL50 External Id：HMS1262

实验名称：Antagonist activity at human CB1 receptor expressed in CHO cells assessed as inhibiti... 来源：ChEMBL 靶标：Cannabinoid receptor 1 External Id：CHEMBL5529045

实验名称：A screen for small molecules that modulate mitochondrial supercomplex formation 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：N/A External Id：HMS1482

实验名称：Cell-based high throughput primary assay to identify activators of GPR151 来源：The Scripps Research Institute Molecular Screening Center 靶标：RecName: Full=G-protein coupled receptor 151; AltName: Full=G-protein coupled receptor PGR7; AltName: Full=GPCR-2037; AltName: Full=Galanin receptor 4; AltName: Full=Galanin-receptor-like protein; Short=GalRL External Id：GPR151_PHUNTER_AG_LUMI_1536_1X%ACT

实验名称：AlphaScreen-based biochemical high throughput primary assay to identify inhibitors of... 来源：The Scripps Research Institute Molecular Screening Center External Id：MITF_INH_Alpha_1536_1X%INH PRUN

实验名称：Stabilization of p53 in human papillomavirus-positive cells 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：Cellular tumor antigen p53 External Id：HMS1485

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英文别名

• Cannabidiorcol
• Cannabidiorocol
• 2-[(1R,6R)-6-Isopropenyl-3-methyl-2-cyclohexen-1-yl]-5-methyl-1,3-benzenediol
• O 1821