维洛沙秦

• 常用名: 维洛沙秦
• 英文名: 2-[(2-ethoxyphenoxy)methyl]morpholine
• CAS号: 46817-91-8
• 分子量: 237.29500
• 密度: 1.061 g/cm3
• 沸点: 350.5ºC at 760 mmHg
• 分子式: C₁₃H₁₉NO₃
• 熔点: 185-186ºC
• 闪点: 144.3ºC

维洛沙秦用途

维洛嗪(维洛嗪)是一种去甲肾上腺素再摄取抑制剂,也是一种有效的5-HT2C激动剂和5-HT2B拮抗剂,其EC50分别为32μM和27μM。维洛嗪的作用机制主要涉及5-羟色胺能和去甲肾上腺素能途径。维洛嗪可用于研究抑郁症[1][2]。

维洛沙秦名称

• 中文名: 维洛沙秦
• 英文名: 2-[(2-ethoxyphenoxy)methyl]morpholine
• 中文别名: 2-((2-乙氧基苯氧基)甲基)吗啉

维洛沙秦生物活性

• 描述: 维洛嗪(维洛嗪)是一种去甲肾上腺素再摄取抑制剂,也是一种有效的5-HT2C激动剂和5-HT2B拮抗剂,其EC50分别为32μM和27μM。维洛嗪的作用机制主要涉及5-羟色胺能和去甲肾上腺素能途径。维洛嗪可用于研究抑郁症[1][2]。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 肾上腺素能受体
  研究领域 >> 神经疾病
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 5-HT受体
  信号通路 >> 神经信号通路 >> 5-HT受体
• 靶点实验:

  Human 5-HT2C Receptor:32 μM (EC50)

  human 5-HT2B Receptor:27 μM (IC50)

• 参考文献:

  [1]. Yu C, et al. New Insights into the Mechanism of Action of Viloxazine: Serotonin and Norepinephrine Modulating Properties. J Exp Pharmacol. 2020 Aug 25;12:285-300.

  [2]. Pinder RM, et al. Viloxazine: a review of its pharmacological properties and therapeutic efficacy in depressive illness. Drugs. 1977 Jun;13(6):401-21.

维洛沙秦物理化学性质

• 密度: 1.061 g/cm3
• 沸点: 350.5ºC at 760 mmHg
• 熔点: 185-186ºC
• 分子式: C₁₃H₁₉NO₃
• 分子量: 237.29500
• 闪点: 144.3ºC
• 精确质量: 237.13600
• PSA: 39.72000
• LogP: 1.78130
• InChIKey: YWPHCCPCQOJSGZ-UHFFFAOYSA-N
• SMILES: CCOc1ccccc1OCC1CNCCO1
• 折射率: 1.499

维洛沙秦毒性和生态

维洛沙秦靶点实验

查看更多实验

实验名称：Binding affinity towards human GABRA1 in an in vitro assay with cellular components m... 来源：ChEMBL 靶标：Gamma-aminobutyric acid receptor subunit gamma-2 External Id：CHEMBL5291799

实验名称：Binding affinity towards human GCGR in an in vitro assay with cellular components mea... 来源：ChEMBL 靶标：Glucagon receptor External Id：CHEMBL5291802

实验名称：Compound was evaluated for inhibition of rat Gabra1 in an in vitro assay with cellula... 来源：ChEMBL 靶标：Gamma-aminobutyric acid receptor subunit alpha-1 External Id：CHEMBL5291801

实验名称：Binding affinity towards human GABBR1 in an in vitro assay with cellular components m... 来源：ChEMBL 靶标：Gamma-aminobutyric acid type B receptor subunit 1 External Id：CHEMBL5291795

实验名称：Binding affinity towards rat Gabra1 in an in vitro assay with cellular components mea... 来源：ChEMBL 靶标：Gamma-aminobutyric acid receptor subunit alpha-1 External Id：CHEMBL5291798

实验名称：Human intestinal absorption in po dosed human 来源：ChEMBL 靶标：Homo sapiens External Id：CHEMBL1116254

实验名称：Binding affinity towards human ESR1 in an in vitro cell free assay (CRO assay) measur... 来源：ChEMBL 靶标：Estrogen receptor External Id：CHEMBL5291792

实验名称：Binding affinity towards human ESR1 in an in vitro cell free assay (NIBR assay) measu... 来源：ChEMBL 靶标：Estrogen receptor External Id：CHEMBL5291791

实验名称：Compound was evaluated for inhibition of human F2 in an in vitro cell free assay meas... 来源：ChEMBL 靶标：Prothrombin External Id：CHEMBL5291794

实验名称：Binding affinity towards human ESR2 in an in vitro cell free assay measured by fluore... 来源：ChEMBL 靶标：Estrogen receptor beta External Id：CHEMBL5291793

共186条，当前第1页，共19页

1

2

3

4

5

维洛沙秦英文别名

• Emovit
• Morpholine,2-((2-ethoxyphenoxy)methyl)
• Viloxazinum [INN-Latin]
• 2-(2-Ethoxy-phenoxymethyl)-morpholine
• 2-(o-ethoxyphenoxymethyl)morpholine
• viloxazine
• Viloxazina [INN-Spanish]
• Viloxazin