胆固醇-5-烯-3β,24(S)-二醇

• 常用名: 胆固醇-5-烯-3β,24(S)-二醇
• 英文名: 24(S)-Hydroxycholesterol
• CAS号: 474-73-7
• 分子量: 402.653
• 密度: 1.0±0.1 g/cm3
• 沸点: 513.1±23.0 °C at 760 mmHg
• 分子式: C₂₇H₄₆O₂
• 熔点: 174-176°C (lit.)
• 闪点: 213.5±17.2 °C

胆固醇-5-烯-3β,24(S)-二醇用途

24(S)-Hydroxycholesterol (24S-OHC) 是脑胆固醇的主要代谢物,对维持脑内胆固醇的稳态起主要作用。24(S)-Hydroxycholesterol (24S-OHC) 是非常有效的内源性的 LXR 的激动剂,在大脑和循环系统中含量高。24(S)-Hydroxycholesterol (24S-OHC) 是有效直接的、选择性的NMDARs 的阳性变构调节剂,其机制不会与其它异构调节因子重叠。

胆固醇-5-烯-3β,24(S)-二醇名称

• 中文名: cholest-5-ene-3β,24(S)-diol
• 英文名: (24S)-24-hydroxycholesterol

胆固醇-5-烯-3β,24(S)-二醇生物活性

• 描述: 24(S)-Hydroxycholesterol (24S-OHC) 是脑胆固醇的主要代谢物,对维持脑内胆固醇的稳态起主要作用。24(S)-Hydroxycholesterol (24S-OHC) 是非常有效的内源性的 LXR 的激动剂,在大脑和循环系统中含量高。24(S)-Hydroxycholesterol (24S-OHC) 是有效直接的、选择性的NMDARs 的阳性变构调节剂,其机制不会与其它异构调节因子重叠。
• 相关类别:
  信号通路 >> 神经信号通路 >> iGluR
  信号通路 >> 代谢酶/蛋白酶 >> LXR
  研究领域 >> 代谢疾病
  信号通路 >> 跨膜转运 >> iGluR
• 靶点实验:

  Human Endogenous Metabolite

• 参考文献:

  [1]. Yuki Kimura, et al. Tocopherol suppresses 24(S)-hydroxycholesterol-induced cell death via inhibition of CaMKII phosphorylation. Biochimie. 2018 Oct;153:203-209.

  [2]. M Shafaati, et al. Enhanced production of 24S-hydroxycholesterol is not sufficient to drive liver X receptor target genes in vivo. J Intern Med. 2011 Oct;270(4):377-87.

  [3]. Steven M Paul, et al. The major brain cholesterol metabolite 24(S)-hydroxycholesterol is a potent allosteric modulator of N-methyl-D-aspartate receptors. J Neurosci. 2013 Oct 30;33(44):17290-300.

胆固醇-5-烯-3β,24(S)-二醇物理化学性质

• 密度: 1.0±0.1 g/cm3
• 沸点: 513.1±23.0 °C at 760 mmHg
• 熔点: 174-176°C (lit.)
• 分子式: C₂₇H₄₆O₂
• 分子量: 402.653
• 闪点: 213.5±17.2 °C
• 精确质量: 402.349792
• PSA: 40.46000
• LogP: 7.66
• InChIKey: IOWMKBFJCNLRTC-XWXSNNQWSA-N
• SMILES: CC(C)C(O)CCC(C)C1CCC2C3CC=C4CC(O)CCC4(C)C3CCC12C
• 蒸汽压: 0.0±3.0 mmHg at 25°C
• 折射率: 1.536
• 储存条件: 20°C

胆固醇-5-烯-3β,24(S)-二醇靶点实验

查看更多实验

实验名称：Increase in light chain 3-GFP+ autophagosome vesicle area per cell in human H4 cells ... 来源：ChEMBL 靶标：H4 External Id：CHEMBL937036

实验名称：Positive allosteric modulation of recombinant human GluN1/GluN2A receptor stably expr... 来源：ChEMBL 靶标：Glutamate receptor ionotropic, NMDA 2A External Id：CHEMBL4408248

实验名称：Positive allosteric modulation of recombinant human GluN1/GluN2A receptor stably expr... 来源：ChEMBL 靶标：Glutamate receptor ionotropic, NMDA 2A External Id：CHEMBL4408249

实验名称：Positive allosteric modulation of recombinant human GluN1/GluN2B receptor stably expr... 来源：ChEMBL 靶标：Glutamate receptor ionotropic, NMDA 2B External Id：CHEMBL4408250

实验名称：Positive allosteric modulation of recombinant human GluN1/GluN2B receptor stably expr... 来源：ChEMBL 靶标：Glutamate receptor ionotropic, NMDA 2B External Id：CHEMBL4408251

实验名称：Concentration required for half maximal activity was calculated in human nuclear oxys... 来源：ChEMBL 靶标：Oxysterols receptor LXR-alpha External Id：CHEMBL710255

实验名称：Tested for its ability to activate Liver X receptor-alpha expressed as Relative effic... 来源：ChEMBL 靶标：Oxysterols receptor LXR-alpha External Id：CHEMBL712591

实验名称：Increase in light chain 3-GFP+ autophagosome vesicle number per cell in human H4 cell... 来源：ChEMBL 靶标：H4 External Id：CHEMBL922366

实验名称：Human Liver X receptor-alpha (1H. Liver X receptor-like receptors) 来源：IUPHAR-DB 靶标：Liver X receptor-alpha (1H. Liver X receptor-like receptors) [Homo sapiens] External Id：602_Human

实验名称：Oral bioavailability in rat 来源：ChEMBL 靶标：N/A External Id：CHEMBL5136788

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胆固醇-5-烯-3β,24(S)-二醇英文别名

• 24S-hydroxycholesterol
• Cholest-5-ene-3,24-diol
• cholest-5-en-3beta,24S-diol
• cholest-5-ene-3b,24a-diol
• (3b,24S)-Cholest-5-ene-3,24-diol
• 24(S)-hydroxycholesterol
• (3S,8S,9S,10R,13R,14S,17R)-17-[(2R,5S)-5-hydroxy-6-methylheptan-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol
• (3β,24S)-Cholest-5-ene-3,24-diol
• 24S-Cholest-5-ene-3b,24-diol
• 24S-OHC
• Cerebrosterol
• 24-hydroxycholesterol
• 24S-Hydroxy-cholesterol