芹菜脑

• 常用名: 芹菜脑
• 英文名: Apiole (parsley)
• CAS号: 523-80-8
• 分子量: 222.24
• 密度: 1.151g/cm3
• 沸点: 294ºC
• 分子式: C₁₂H₁₄O₄
• 熔点: 29ºC
• 闪点: 117.2ºC

芹菜脑用途

Apiole 是一种诱导凋亡 (apoptosis) 的抗肿瘤剂,诱导 G0/G1 细胞周期停滞而抑制人结肠癌细胞。Apiole 还在小鼠体内异种移植模型中显著抑制结肠肿瘤的发展。

芹菜脑名称

• 中文名: 洋芹脑
• 英文名: 4,7-dimethoxy-5-prop-2-enyl-1,3-benzodioxole
• 中文别名: 1,2-亚甲基二氧基-3,6-二甲氧基-4-烯丙基苯 | 2,5-二甲氧黃樟油精 | 芹菜脑

芹菜脑生物活性

• 描述: Apiole 是一种诱导凋亡 (apoptosis) 的抗肿瘤剂,诱导 G0/G1 细胞周期停滞而抑制人结肠癌细胞。Apiole 还在小鼠体内异种移植模型中显著抑制结肠肿瘤的发展。
• 相关类别:
  信号通路 >> 细胞凋亡 >> 细胞凋亡
  研究领域 >> 癌症
• 参考文献:

  [1]. Wu KH, et al. Study of the antitumor mechanisms of apiole derivatives (AP-02) from Petroselinum crispum through induction of G0/G1 phase cell cycle arrest in human COLO 205 cancer cells. BMC Complement Altern Med. 2019 Jul 27;19(1):188.

  [2]. Wei PL, et al. The in vivo antitumor effects on human COLO 205 cancer cells of the 4,7-dimethoxy-5-(2-propen-1-yl)-1,3-benzodioxole (apiole) derivative of 5-substituted 4,7-dimethoxy-5-methyl-l,3-benzodioxole (SY-1) isolated from the fruiting body of Antrodia camphorate. J Cancer Res Ther. 2012 Oct-Dec;8(4):532-6.

芹菜脑物理化学性质

• 密度: 1.151g/cm3
• 沸点: 294ºC
• 熔点: 29ºC
• 分子式: C₁₂H₁₄O₄
• 分子量: 222.24
• 闪点: 117.2ºC
• 精确质量: 222.08900
• PSA: 36.92000
• LogP: 2.16100
• InChIKey: QQRSPHJOOXUALR-UHFFFAOYSA-N
• SMILES: C=CCc1cc(OC)c2c(c1OC)OCO2
• 折射率: 1.53
• 储存条件: 库房通风低温干燥,与食品原料分开存放

芹菜脑毒性和生态

芹菜脑安全信息

• 风险声明 (欧洲): 36/37/38
• 安全声明 (欧洲): 26-36/37/39
• 海关编码: 2932999099

芹菜脑海关

• 海关编码: 2932999099
• 中文概述: 2932999099. 其他仅含氧杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
• 申报要素: 品名, 成分含量, 用途
• Summary: 2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

芹菜脑靶点实验

查看更多实验

实验名称：ERK5 transcriptional activity HTS 来源：24565 靶标：N/A External Id：ERK5 transcriptional activity-HTS

实验名称：qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in... 来源：NCGC 靶标：TDP1 protein [Homo sapiens] External Id：TDP1100

实验名称：qHTS for Stage-Specific Inhibitors of Vaccinia Orthopoxvirus: mCherry Reporter Primar... 来源：NCGC 靶标：67.9K protein [Vaccinia virus] External Id：Vaccinia-p2mCherry

实验名称：qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in... 来源：NCGC 靶标：TDP1 protein [Homo sapiens] External Id：TDP1101

实验名称：Inhibition of sodium fluorescein uptake in OATP1B3-transfected CHO cells at an equimo... 来源：ChEMBL 靶标：Solute carrier organic anion transporter family member 1B3 External Id：CHEMBL3039491

实验名称：Antimitotic activity against Paracentrotus lividus embryo assessed as cleavage altera... 来源：ChEMBL 靶标：Paracentrotus lividus External Id：CHEMBL1648466

实验名称：The chemical genetic matrix (CGM) dataset as reported in Wildenhain et al. (2015) Pre... 来源：11924 靶标：N/A External Id：CGM data for Cell Systems paper Dec 2015

实验名称：qHTS for Stage-Specific Inhibitors of Vaccinia Orthopoxvirus: Venus Reporter Primary ... 来源：NCGC 靶标：67.9K protein [Vaccinia virus] External Id：Vaccinia-p2Venus

实验名称：GPR151 activator identification: cell-based high-throughput counter-screen assay 来源：The Scripps Research Institute Molecular Screening Center 靶标：RecName: Full=Glucose-dependent insulinotropic receptor; AltName: Full=G-protein coupled receptor 119 External Id：GPR119_PHUNTER_AG_LUMI_1536_3X%ACT CSRUN1

实验名称：GPR151 activator identification: cell-based high-throughput confirmation assay 来源：The Scripps Research Institute Molecular Screening Center 靶标：RecName: Full=G-protein coupled receptor 151; AltName: Full=G-protein coupled receptor PGR7; AltName: Full=GPCR-2037; AltName: Full=Galanin receptor 4; AltName: Full=Galanin-receptor-like protein; Short=GalRL External Id：GPR151_PHUNTER_AG_LUMI_1536_3X%ACT CRUN1

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芹菜脑英文别名

• Apiole (parsley)
• Apiol
• 1-allyl-2,5-dimethoxy-3,4-methylenedioxybenzene
• Petersiliencampher
• 3,6-dimethoxy-4,5-methylenedioxy-allylbenzene
• 1-allyl-3,4-methylenedioxy-2,5-dimethoxybenzene
• Apiole
• Apioline
• 5-Allyl-4,7-dimethoxy-1,3-benzodioxole
• Parsley apiol
• 1,3-Benzodioxole,4,7-dimethoxy-5-(2-propenyl)
• Parsley apiole
• Parsley camphor