Apiole (parsley)

Modify Date: 2024-01-04 08:59:30

Apiole (parsley) structure	Common Name	Apiole (parsley)
	CAS Number	523-80-8	Molecular Weight	222.24
	Density	1.151g/cm3	Boiling Point	294ºC
	Molecular Formula	C₁₂H₁₄O₄	Melting Point	29ºC
	MSDS	N/A	Flash Point	117.2ºC

Use of Apiole (parsley)

Apiole is an anti-tumor agent that induces apoptosis and inhibits human colon cancer cells by inducing G0/G1 cell cycle arrest. Apiole also significantly inhibited colon tumor development in an in vivo mouse xenograft model[1][2].

Name	4,7-dimethoxy-5-prop-2-enyl-1,3-benzodioxole
Synonym	More Synonyms

Description	Apiole is an anti-tumor agent that induces apoptosis and inhibits human colon cancer cells by inducing G0/G1 cell cycle arrest. Apiole also significantly inhibited colon tumor development in an in vivo mouse xenograft model[1][2].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer
References	[1]. Wu KH, et al. Study of the antitumor mechanisms of apiole derivatives (AP-02) from Petroselinum crispum through induction of G0/G1 phase cell cycle arrest in human COLO 205 cancer cells. BMC Complement Altern Med. 2019 Jul 27;19(1):188. [2]. Wei PL, et al. The in vivo antitumor effects on human COLO 205 cancer cells of the 4,7-dimethoxy-5-(2-propen-1-yl)-1,3-benzodioxole (apiole) derivative of 5-substituted 4,7-dimethoxy-5-methyl-l,3-benzodioxole (SY-1) isolated from the fruiting body of Antrodia camphorate. J Cancer Res Ther. 2012 Oct-Dec;8(4):532-6.

Description

Related Catalog

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cancer

References

[1]. Wu KH, et al. Study of the antitumor mechanisms of apiole derivatives (AP-02) from Petroselinum crispum through induction of G0/G1 phase cell cycle arrest in human COLO 205 cancer cells. BMC Complement Altern Med. 2019 Jul 27;19(1):188.

[2]. Wei PL, et al. The in vivo antitumor effects on human COLO 205 cancer cells of the 4,7-dimethoxy-5-(2-propen-1-yl)-1,3-benzodioxole (apiole) derivative of 5-substituted 4,7-dimethoxy-5-methyl-l,3-benzodioxole (SY-1) isolated from the fruiting body of Antrodia camphorate. J Cancer Res Ther. 2012 Oct-Dec;8(4):532-6.

Density	1.151g/cm3
Boiling Point	294ºC
Melting Point	29ºC
Molecular Formula	C₁₂H₁₄O₄
Molecular Weight	222.24
Flash Point	117.2ºC
Exact Mass	222.08900
PSA	36.92000
LogP	2.16100
Index of Refraction	1.53

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CY2500000

CHEMICAL NAME :: Benzene, 1-allyl-2,5-dimethoxy-3,4-(methylenedioxy)-

CAS REGISTRY NUMBER :: 523-80-8

BEILSTEIN REFERENCE NO. :: 0195747

LAST UPDATED :: 199701

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C12-H14-O4

MOLECULAR WEIGHT :: 222.26

WISWESSER LINE NOTATION :: T56 BO DO CHJ FO1 H2U1 IO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Amphibian - frog

DOSE/DURATION :: 1515 mg/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Behavioral - altered sleep time (including change in righting reflex) Lungs, Thorax, or Respiration - other changes

MUTATION DATA

TEST SYSTEM :: Rodent - mouse

DOSE/DURATION :: 400 mg/kg

REFERENCE :: CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 5,1613,1984

Risk Phrases	36/37/38
Safety Phrases	26-36/37/39
HS Code	2932999099

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HS Code	2932999099
Summary	2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Apiole (parsley)

Apiol

1-allyl-2,5-dimethoxy-3,4-methylenedioxybenzene

Petersiliencampher

3,6-dimethoxy-4,5-methylenedioxy-allylbenzene

1-allyl-3,4-methylenedioxy-2,5-dimethoxybenzene

Apiole

Apioline

5-Allyl-4,7-dimethoxy-1,3-benzodioxole

Parsley apiol

1,3-Benzodioxole,4,7-dimethoxy-5-(2-propenyl)

Parsley apiole

Parsley camphor

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Apiole (parsley)
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Purity: 99.0%
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DC Chemicals Limited
China
Product Name: Apiole (parsley)
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 1-ALLYL-2,5-DIMETHOXY-3,4-METHYLENE DIOXYBENZENE
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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