URB-597

• 常用名: URB-597
• 英文名: URB597
• CAS号: 546141-08-6
• 分子量: 338.400
• 密度: 1.2±0.1 g/cm3
• 沸点: 533.2±50.0 °C at 760 mmHg
• 分子式: C₂₀H₂₂N₂O₃
• 熔点: N/A
• 闪点: 276.3±30.1 °C
• 符号: GHS07, GHS09
• 信号词: Warning

URB-597用途

URB597是口服生物相容性的FAAH抑制剂,IC50为4.6 nM,对其它的cannabinoid-相关靶点无活性。

URB-597名称

• 中文名: 3'-氨基甲酰-[1,1'-联苯]-3-基环己基氨基甲酸酯
• 英文名: 3'-Carbamoyl-[1,1'-biphenyl]-3-yl cyclohexylcarbamate
• 中文别名: 东凌草素 | 3'-胺甲酰基联苯-3-基环己基氨基甲酸甲酯 | 3'-胺甲酰基联苯-3-基环己基氨基甲酸酯 | N-环己基氨基甲酸 3'-(氨基甲酰基)[1,1'-联苯]-3-基酯

URB-597生物活性

• 描述: URB597是口服生物相容性的FAAH抑制剂,IC50为4.6 nM,对其它的cannabinoid-相关靶点无活性。
• 相关类别:
  信号通路 >> 自噬 >> 自噬
  信号通路 >> 代谢酶/蛋白酶 >> FAAH
  信号通路 >> 神经信号通路 >> FAAH
  信号通路 >> 自噬 >> 自噬
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Mor M, et al. Cyclohexylcarbamic acid 3'- or 4'-substituted biphenyl-3-yl esters as fatty acid amide hydrolase inhibitors: synthesis, quantitative structure-activity relationships, and molecular modeling studies. J Med Chem, 2004, 47(21), 4998-5008.

  [2]. Tham CS, et al. Inhibition of microglial fatty acid amide hydrolase modulates LPS stimulated release of inflammatory mediators. FEBS Lett, 2007, 581(16), 2899-2904.

  [3]. Fegley D, et al. Characterization of the fatty acid amide hydrolase inhibitor cyclohexyl carbamic acid 3'-carbamoyl-biphenyl-3-yl ester (URB597): effects on anandamide and oleoylethanolamide deactivation. J Pharmacol Exp Ther. 2005 Apr;313(1):352-8.

  [4]. Jayamanne A, et al. Actions of the FAAH inhibitor URB597 in neuropathic and inflammatory chronic pain models. Br J Pharmacol, 2006, 147(3), 281-288.

URB-597物理化学性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 533.2±50.0 °C at 760 mmHg
• 分子式: C₂₀H₂₂N₂O₃
• 分子量: 338.400
• 闪点: 276.3±30.1 °C
• 精确质量: 338.163055
• PSA: 81.42000
• LogP: 3.51
• InChIKey: ROFVXGGUISEHAM-UHFFFAOYSA-N
• SMILES: NC(=O)c1cccc(-c2cccc(OC(=O)NC3CCCCC3)c2)c1
• 外观性状: powder | white
• 蒸汽压: 0.0±1.4 mmHg at 25°C
• 折射率: 1.618
• 储存条件: 2-8°C
• 水溶解性: DMSO: ~14 mg/mL, soluble

URB-597MSDS

URB-597MSDS英文版

URB-597安全信息

• 符号: GHS07, GHS09
• 信号词: Warning
• 危害声明: H319-H410
• 警示性声明: P273-P305 + P351 + P338-P501
• 个人防护装备: Eyeshields;Gloves
• 危害码 (欧洲): N
• 风险声明 (欧洲): 50/53
• 安全声明 (欧洲): 22-24/25-60-61
• 危险品运输编码: UN 3077 9/PG 3
• WGK德国: 3
• 海关编码: 2924299090

URB-597海关

• 海关编码: 2924299090
• 中文概述: 2924299090. 其他环酰胺（包括环氨基甲酸酯）（包括其衍生物以及他们的盐）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%
• 申报要素: 品名, 成分含量, 用途, 包装
• Summary: 2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

URB-597靶点实验

查看更多实验

实验名称：Inhibition of FAAH in mouse brain membranes using [14C]-AEA as substrate incubated fo... 来源：ChEMBL 靶标：Fatty-acid amide hydrolase 1 External Id：CHEMBL4409077

实验名称：Displacement of [3H]-spiperone from human D2 receptor expressed in CHO cells co-expre... 来源：ChEMBL 靶标：D(2) dopamine receptor External Id：CHEMBL4409079

实验名称：Displacement of [3H]-spiperone from human D3 receptor expressed in CHO cells co-expre... 来源：ChEMBL 靶标：D(3) dopamine receptor External Id：CHEMBL4409080

实验名称：Primary qHTS assay for inhibitors of alpha-synuclein gene (SNCA) expression 来源：NCGC External Id：SNCA-p-activity-luciferase

实验名称：Inhibition of human ERG expressed in HEK293 cells incubated for 72 hrs by patch clamp... 来源：ChEMBL 靶标：Potassium voltage-gated channel subfamily H member 2 External Id：CHEMBL4409081

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against th... 来源：NCGC 靶标：N/A External Id：s-my-keats_OPM1-m4-1

实验名称：Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against th... 来源：NCGC 靶标：N/A External Id：s-my-OC1MY5-m4-1

实验名称：Inhibition of human recombinant MAGL at 10 uM using 1,3-dihydroxypropan-2-yl 4-pyren-... 来源：ChEMBL 靶标：Monoglyceride lipase External Id：CHEMBL4383626

实验名称：Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against th... 来源：NCGC 靶标：N/A External Id：s-my-KMS_34-m4-1

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URB-597英文别名

• cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester
• URB597
• 3'-Carbamoyl-3-biphenylyl cyclohexylcarbamate
• Carbamic acid, N-cyclohexyl-, 3'-(aminocarbonyl)[1,1'-biphenyl]-3-yl ester
• 3'-Carbamoylbiphenyl-3-yl cyclohexylcarbamate
• Cyclohexyl-carbamic acid 3'-carbamoyl-biphenyl-3-yl ester
• [3-(3-carbamoylphenyl)phenyl] N-cyclohexylcarbamate
• 3'-(aminocarbonyl)-1,1'-biphenyl-3-yl cyclohexylcarbamate
• URB-597