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ML204

ML204用途

ML204是TRPC4/C5离子通道新型高效抑制剂。

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ML204名称

[ CAS 号 ]:
5465-86-1

[ 中文名 ]:
ML204

[ 英文名 ]:
ML204

[英文别名 ]:

Quinoline, 4-methyl-2-(1-piperidinyl)-
4-methyl-2-piperidylquinoline
4-methyl-2-(piperidin-1-yl)quinoline
2-Piperidino-4-methyl-chinolin
ML204
4-Methyl-2-(1-piperidinyl)-quinoline
4-Methyl-2-(1-piperidinyl)quinoline
2-Piperidino-lepidin

ML204生物活性

[ 描述 ]:

ML204是TRPC4/C5离子通道新型高效抑制剂。

[ 相关类别 ]:

信号通路 >> 跨膜转运 >> TRP频道

研究领域 >> 神经疾病

[参考文献]

[1]. Miller M, et al. Identification of ML204, a novel potent antagonist that selectively modulates native TRPC4/C5 ion channels. J Biol Chem. 2011 Sep 23;286(38):33436-46.

[2]. Miller MR, et al. Novel Chemical Inhibitor of TRPC4 Channels. Probe Reports from the NIH Molecular Libraries Program [Internet].

[相关活性小分子]

辣椒碱 | 辣椒平 | 5-(N-乙基-N-异丙基)阿米洛利 | 氯化二亚苯基碘鎓 | 2-(1,3-二甲基-2,6-二氧代-2,3-二氢-1H-嘌呤-7(6H)-基)-N-(4-异丙基苯基)乙酰胺 | 1-[2-(4-甲氧基)-2-[3-(4-甲氧基苯基)丙氧基]乙基]咪唑 | HC-067047 | AMG9810 | GSK1016790A | SAR7334 | PF-4840154 | RN-1734 | AMG 517 | 3-(4-氯苯基)-N-(3-甲氧基苯基)-2-丙烯酰胺 | 冰素

ML204物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
404.4±33.0 °C at 760 mmHg

[ 分子式 ]:
C₁₅H₁₈N₂

[ 分子量 ]:
226.317

[ 闪点 ]:
198.4±25.4 °C

[ 精确质量 ]:
226.147003

[ PSA ]:
16.13000

[ LogP ]:
3.92

[ 外观性状 ]:
粉末

[ 蒸汽压 ]:
0.0±0.9 mmHg at 25°C

[ 折射率 ]:
1.617

[ 储存条件 ]:
-20℃

ML204安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302

[ 危险品运输编码 ]:
NONH for all modes of transport

ML204合成路线

详细合成路线

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ML204文献

Do male secondary sexual characters correlate with testis size and sperm length in the small hairy maggot blowfly?

Zoology (Jena.) 118 , 439-45, (2015)

The phenotype-linked fertility hypothesis proposes that secondary sexual characters (SSCs) advertise a male's fertility to prospective mates. However, findings from empirical studies attempting to tes...

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