5-马来酰亚胺戊酸

• 常用名: 5-马来酰亚胺戊酸
• 英文名: 5-Maleimidovaleric acid
• CAS号: 57078-99-6
• 分子量: 197.188
• 密度: 1.3±0.1 g/cm3
• 沸点: 400.7±28.0 °C at 760 mmHg
• 分子式: C₉H₁₁NO₄
• 熔点: N/A
• 闪点: 196.2±24.0 °C

5-马来酰亚胺戊酸用途

5-Maleimidovaleric acid 是一种可降解 (cleavable) 的 ADC linker,可用于合成抗体偶联药物 (ADC)。

5-马来酰亚胺戊酸名称

• 中文名: 5-马来酰亚胺戊酸
• 英文名: 5-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)pentanoic acid

5-马来酰亚胺戊酸生物活性

• 描述: 5-Maleimidovaleric acid 是一种可降解 (cleavable) 的 ADC linker,可用于合成抗体偶联药物 (ADC)。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 抗体- 药物偶联物 >> ADC连接器
• 靶点实验:

  Cleavable

• 体外研究: ADC由抗体组成,抗体通过ADC连接体连接ADC细胞毒素[1]。
• 参考文献:

  [1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.

5-马来酰亚胺戊酸物理化学性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 400.7±28.0 °C at 760 mmHg
• 分子式: C₉H₁₁NO₄
• 分子量: 197.188
• 闪点: 196.2±24.0 °C
• 精确质量: 197.068802
• PSA: 74.68000
• LogP: 0.56
• InChIKey: ACVAAFHNDGTZLL-UHFFFAOYSA-N
• SMILES: O=C(O)CCCCN1C(=O)C=CC1=O
• 蒸汽压: 0.0±2.0 mmHg at 25°C
• 折射率: 1.544
• 储存条件: 室温，干燥

5-马来酰亚胺戊酸安全信息

• 危害码 (欧洲): Xi
• 海关编码: 2925190090

5-马来酰亚胺戊酸海关

• 海关编码: 2925190090
• 中文概述: 2925190090 其他酰亚胺及其衍生物盐. 增值税率:17.0% 退税率:9.0% 监管条件:无 最惠国关税:6.5% 普通关税:30.0%
• 申报要素: 品名, 成分含量, 用途
• Summary: 2925190090 other imides and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

5-马来酰亚胺戊酸靶点实验

查看更多实验

实验名称：QFRET-based biochemical primary high throughput screening assay to identify exosite i... 来源：The Scripps Research Institute Molecular Screening Center 靶标：disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] External Id：ADAM17_INH_QFRET_1536_1X%INH PRUN

实验名称：Luminescence-based cell-based primary high throughput screening assay to identify act... 来源：The Scripps Research Institute Molecular Screening Center 靶标：TTR [Homo sapiens] External Id：TTR_ACT_LUMI_1536_1X%ACT PRUN

实验名称：Counterscreen for inhibitors of 5-meCpG-binding domain protein 2 (MBD2): TRFRET-based... 来源：The Scripps Research Institute Molecular Screening Center 靶标：E3 ubiquitin-protein ligase UHRF1 isoform 1 [Homo sapiens] External Id：UHRF1-CPGDNA_INH_TRFRET_1536_1X%INH CSRUN for MBD2-CPGDNA INH

实验名称：Luminescence-based cell-based primary high throughput screening assay for inhibitors ... 来源：The Scripps Research Institute Molecular Screening Center 靶标：nuclear receptor subfamily 0 group B member 1 [Homo sapiens] External Id：DAX1-FULL_INH_LUMI_1536_1X%INH PRUN

实验名称：uHTS identification of small molecule modulators of Rev-erb Alpha. 来源：Burnham Center for Chemical Genomics 靶标：N/A External Id：SBCCG-A1016-RevErbaLBD-Primary-Assay

实验名称：HTS for Bacterial rRNA inhibitors Measured in Microorganism-Based System Using Plate ... 来源：Broad Institute 靶标：N/A External Id：7056-01_Inhibitor_SinglePoint_HTS_Activity

实验名称：Fluorescence-based biochemical high throughput primary assay to identify inhibitors o... 来源：The Scripps Research Institute Molecular Screening Center 靶标：Phospholipase C, beta 3 (phosphatidylinositol-specific) [Homo sapiens] External Id：PLCB3_INH_QFRET_1536_1X%INH PRUN

实验名称：QFRET-based biochemical primary high throughput screening assay to identify exosite i... 来源：The Scripps Research Institute Molecular Screening Center 靶标：ADAM10 [Homo sapiens] External Id：ADAM10_INH_QFRET_1536_1X%INH PRUN

实验名称：Luminescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：Protein DAF-12, isoform a [Caenorhabditis elegans] External Id：HGDAF12_AG_LUMI_1536_1X%ACT PRUN

实验名称：Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfect... 来源：Broad Institute 靶标：N/A External Id：Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfected HEK293 cells Inhibition - 7011-01_Antagonist_SinglePoint_HTS_Activity

共24条，当前第1页，共3页

1

2

3

5-马来酰亚胺戊酸英文别名

• 5-(2,5-dioxopyrrol-1-yl)pentanoic acid
• 5-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)pentanoic acid
• 5-Maleimidovaleric acid