盐酸阿立必利

• 常用名: 盐酸阿立必利
• 英文名: alizapride hydrochloride
• CAS号: 59338-87-3
• 分子量: 351.831
• 密度: 1.224 g/cm3
• 沸点: 580.3ºC at 760 mmHg
• 分子式: C₁₆H₂₂ClN₅O₂
• 熔点: 206-208°
• 闪点: 304.8ºC

盐酸阿立必利用途

Alizapride hydrochloride 是一种多巴胺受体拮抗剂,具有促运动和止吐作用,也可用于治疗恶心和呕吐,包括术后恶心和呕吐。

盐酸阿立必利名称

• 中文名: 盐酸阿立必利
• 英文名: N-((1-Allylpyrrolidin-2-yl)methyl)-6-methoxy-1H-benzo[d][1,2,3]triazole-5-carboxamide hydrochloride
• 中文别名: 6-甲氧基-N-[(1-丙-2-烯基吡咯烷-2-基)甲基]-2H-苯并三唑-5-甲酰胺盐酸盐

盐酸阿立必利生物活性

• 描述: Alizapride hydrochloride 是一种多巴胺受体拮抗剂,具有促运动和止吐作用,也可用于治疗恶心和呕吐,包括术后恶心和呕吐。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 多巴胺受体
  信号通路 >> 神经信号通路 >> 多巴胺受体
  研究领域 >> 癌症
  研究领域 >> 神经疾病
• 靶点实验:

  Dopamine receptor[1]

• 参考文献:

  [1]. Bleiberg H, et al. Activity of a new antiemetic agent: alizapride. A randomized double-blind crossover controlled trial. Cancer Chemother Pharmacol. 1988;22(4):316-20.

盐酸阿立必利物理化学性质

• 密度: 1.224 g/cm3
• 沸点: 580.3ºC at 760 mmHg
• 熔点: 206-208°
• 分子式: C₁₆H₂₂ClN₅O₂
• 分子量: 351.831
• 闪点: 304.8ºC
• 精确质量: 351.146210
• PSA: 83.14000
• LogP: 2.47750
• InChIKey: BRECEDGYMYXGNF-UHFFFAOYSA-N
• SMILES: C=CCN1CCCC1CNC(=O)c1cc2n[nH]nc2cc1OC.Cl
• 储存条件: 室温，干燥

盐酸阿立必利安全信息

• 海关编码: 2933990090

盐酸阿立必利海关

• 海关编码: 2933990090
• 中文概述: 2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
• 申报要素: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
• Summary: 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

盐酸阿立必利靶点实验

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实验名称：Luminescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：mu-type opioid receptor isoform MOR-1 [Homo sapiens] External Id：OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN

实验名称：QFRET-based biochemical primary high throughput screening assay to identify exosite i... 来源：The Scripps Research Institute Molecular Screening Center 靶标：disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] External Id：ADAM17_INH_QFRET_1536_1X%INH PRUN

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：uHTS identification of small molecule activators of the adaptive arm of the Unfolded ... 来源：Burnham Center for Chemical Genomics 靶标：N/A External Id：BCCG-A405-UPR-XBP1-PrimaryAgonist-Assay

实验名称：Fluorescence polarization to screen for inhibitor that competite the binding of FadD2... 来源：Broad Institute 靶标：FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE) External Id：2147-01_Inhibitor_SinglePoint_HTS_Activity

实验名称：Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfect... 来源：Broad Institute 靶标：N/A External Id：Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfected HEK293 cells Inhibition - 7011-01_Antagonist_SinglePoint_HTS_Activity

实验名称：Dicer-mediated maturation of pre-microRNA 来源：Center for Chemical Genomics, University of Michigan 靶标：N/A External Id：TargetID_659_CEMA

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify pos... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_PAM_FLUO8_1536_1X%ACT PRUN

实验名称：Fluorescence polarization-based biochemical high throughput primary assay to identify... 来源：The Scripps Research Institute Molecular Screening Center 靶标：RecName: Full=Sialate O-acetylesterase; AltName: Full=H-Lse; AltName: Full=Sialic acid-specific 9-O-acetylesterase; Flags: Precursor [Homo sapiens] External Id：SIAE_INH_FP_1536_1X%INH PRUN

实验名称：Absorbance-based primary biochemical high throughput screening assay to identify acti... 来源：The Scripps Research Institute Molecular Screening Center 靶标：caspase-3 preproprotein [Homo sapiens] External Id：PROCASPASE3_ACT_EPIABS_1536_1X%ACT PRUN

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盐酸阿立必利英文别名

• N-[(1-Allyl-2-pyrrolidinyl)methyl]-5-methoxy-1H-benzotriazole-6-carboxamide hydrochloride (1:1)
• N-[(1-Allylpyrrolidin-2-yl)methyl]-6-methoxy-1H-benzotriazole-5-carboxamide hydrochloride (1:1)
• Alizapride HCl
• 1H-1,2,3-Benzotriazole-5-carboxamide, 6-methoxy-N-[[1-(2-propen-1-yl)-2-pyrrolidinyl]methyl]-, hydrochloride (1:1)
• 6-methoxy-N-[(1-prop-2-enylpyrrolidin-2-yl)methyl]-2H-benzotriazole-5-carboxamide,hydrochloride