荛花酚

• 常用名: 荛花酚
• 英文名: (+)-Nortrachelogenin
• CAS号: 61521-74-2
• 分子量: 374.384
• 密度: 1.4±0.1 g/cm3
• 沸点: 609.2±50.0 °C at 760 mmHg
• 分子式: C₂₀H₂₂O₇
• 熔点: N/A
• 闪点: 217.3±23.6 °C

荛花酚用途

(+)-Nortrachelogenin(Wikstromol),一种来自印度wikstroemia的药理学配体,具有抗白血病活性[1]。

荛花酚名称

• 中文名: 荛花酚
• 英文名: (3R,4R)-3-hydroxy-3,4-bis(4-hydroxy-3-methoxybenzyl)dihydrofuran-2(3H)-one

荛花酚生物活性

• 描述: (+)-Nortrachelogenin(Wikstromol),一种来自印度wikstroemia的药理学配体,具有抗白血病活性[1]。
• 相关类别:
  信号通路 >> 细胞凋亡 >> 细胞凋亡
  研究领域 >> 癌症
  信号通路 >> PI3K/Akt/mTOR 信号通路 >> PI3K
• 体外研究: Wikstromol通过抑制PI3K/Akt途径诱导细胞凋亡并抑制MDA-MB-231细胞的迁移[2]。
• 参考文献:

  [1]. A Kato,et al. (+)-Nortrachelogenin, A New Pharmacologically Active Lignan From Wikstroemia indica. J Nat Prod. 1979 Mar;42(2):159-162.

  [2]. Huankai Yao, et al. Wikstromol from Wikstroemia indica induces apoptosis and suppresses migration of MDA-MB-231 cells via inhibiting PI3K/Akt pathway.

荛花酚物理化学性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 609.2±50.0 °C at 760 mmHg
• 分子式: C₂₀H₂₂O₇
• 分子量: 374.384
• 闪点: 217.3±23.6 °C
• 精确质量: 374.136566
• PSA: 105.45000
• LogP: 0.92
• InChIKey: ZITBJWXLODLDRH-JLTOFOAXSA-N
• SMILES: COc1cc(CC2COC(=O)C2(O)Cc2ccc(O)c(OC)c2)ccc1O
• 外观性状: 粉末
• 蒸汽压: 0.0±1.8 mmHg at 25°C
• 折射率: 1.630
• 储存条件: 2-8℃，干燥，密闭

荛花酚安全信息

• 危害码 (欧洲): Xi
• 海关编码: 2932209090

荛花酚海关

• 海关编码: 2932209090
• 中文概述: 2932209090. 其他内酯. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
• 申报要素: 品名, 成分含量, 用途
• Summary: 2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

荛花酚靶点实验

查看更多实验

实验名称：Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induc... 来源：ChEMBL 靶标：RAW264.7 External Id：CHEMBL1043932

实验名称：Effect on central nervous system in mouse assessed as prolongation of anesthesia at 1... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL979471

实验名称：Effect on central nervous system in mouse assessed as prolongation of anesthesia at 6... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL979470

实验名称：HIV Cellular Data 来源：NIAID 靶标：N/A External Id：HIV Cellular Data

实验名称：Cytotoxicity against mouse P388 cells xenografted in CDF1 mouse at 1 mg/kg relative t... 来源：ChEMBL 靶标：P388 External Id：CHEMBL1030023

实验名称：Cytotoxicity against mouse P388 cells xenografted in CDF1 mouse at 2 mg/kg relative t... 来源：ChEMBL 靶标：P388 External Id：CHEMBL1030024

实验名称：Cytotoxicity against mouse P388 cells xenografted in BDF1 mouse at 8 mg/kg relative t... 来源：ChEMBL 靶标：P388 External Id：CHEMBL1029288

实验名称：Cytotoxicity against mouse P388 cells xenografted in BDF1 mouse at 16 mg/kg relative ... 来源：ChEMBL 靶标：P388 External Id：CHEMBL1030022

实验名称：Effect on central nervous system in mouse assessed as tranquilizing activity 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL979473

实验名称：Effect on central nervous system in mouse assessed as prolongation of anesthesia 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL979472

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荛花酚英文别名

• (3R,4R)-3-Hydroxy-3,4-bis(4-hydroxy-3-methoxybenzyl)dihydro-2(3H)-furanone
• (3R-cis)-Dihydro-3,4-bis((4-hydroxy-3-methoxyphenyl)methyl)-3-hydroxy-2(3H)-furanone