Xanthoangelol

• 常用名: Xanthoangelol
• 英文名: Xanthoangelol
• CAS号: 62949-76-2
• 分子量: 392.48700
• 密度: 1.165g/cm3
• 沸点: 605.8ºC at 760 mmHg
• 分子式: C₂₅H₂₈O₄
• 熔点: N/A
• 闪点: 334.2ºC

Xanthoangelol用途

Xanthoangelol 可从Angelica keiskei 中分离得到,可抑制肥胖引起的炎症反应。Xanthoangelol 具有抗菌活性。Xanthoangelol 可抑制单胺氧化酶。Xanthoangelol 诱导神经母细胞瘤和白血病细胞凋亡。

Xanthoangelol名称

• 中文名: 黄色当归醇
• 英文名: (E)-1-[3-[(2E)-3,7-dimethylocta-2,6-dienyl]-2,4-dihydroxyphenyl]-3-(4-hydroxyphenyl)prop-2-en-1-one

Xanthoangelol生物活性

• 描述: Xanthoangelol 可从Angelica keiskei 中分离得到,可抑制肥胖引起的炎症反应。Xanthoangelol 具有抗菌活性。Xanthoangelol 可抑制单胺氧化酶。Xanthoangelol 诱导神经母细胞瘤和白血病细胞凋亡。
• 相关类别:
  信号通路 >> 细胞凋亡 >> 细胞凋亡
  信号通路 >> 表观遗传学 >> AMPK
  研究领域 >> 癌症
  研究领域 >> 感染
  信号通路 >> PI3K/Akt/mTOR 信号通路 >> AMPK
  信号通路 >> 抗感染 >> 细菌
• 参考文献:

  [1]. Li Y, et al. Xanthoangelol and 4-hydroxyderrcin suppress obesity-induced inflammatory responses. Obesity (Silver Spring). 2016 Nov;24(11):2351-2360.

  [2]. Inamori Y, et al. Antibacterial activity of two chalcones, xanthoangelol and 4-hydroxyderricin, isolated from the root of Angelica keiskei KOIDZUMI. Chem Pharm Bull (Tokyo). 1991 Jun;39(6):1604-5.

  [3]. Kim JH, et al. Xanthoangelol and 4-Hydroxyderricin Are the Major Active Principles of the Inhibitory Activities against Monoamine Oxidases on Angelica keiskei K. Biomol Ther (Seoul). 2013 May 30;21(3):234-40.

  [4]. Keiichi TABATA, et al. Xanthoangelol, a Major Chalcone Constituent of Angelica keiskei, Induces Apoptosis in Neuroblastoma and Leukemia Cells. Biol. Pharm. Bull. 28(8) 1404-1407 (2005).

Xanthoangelol物理化学性质

• 密度: 1.165g/cm3
• 沸点: 605.8ºC at 760 mmHg
• 分子式: C₂₅H₂₈O₄
• 分子量: 392.48700
• 闪点: 334.2ºC
• 精确质量: 392.19900
• PSA: 77.76000
• LogP: 5.93470
• InChIKey: LRSMBOSQWGHYCW-MDGZPELGSA-N
• SMILES: CC(C)=CCCC(C)=CCc1c(O)ccc(C(=O)C=Cc2ccc(O)cc2)c1O
• 外观性状: 固体
• 折射率: 1.625
• 储存条件: 2-8°C，密封，干燥

Xanthoangelol靶点实验

查看更多实验

实验名称：Luminescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：mu-type opioid receptor isoform MOR-1 [Homo sapiens] External Id：OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：Inhibition of PTP1B (unknown origin) at 20 ug/ml using pNPP substrate measured after ... 来源：ChEMBL 靶标：Tyrosine-protein phosphatase non-receptor type 1 External Id：CHEMBL3405964

实验名称：Inhibition of PTP1B (unknown origin) using pNPP substrate measured after 3 mins by co... 来源：ChEMBL 靶标：Tyrosine-protein phosphatase non-receptor type 1 External Id：CHEMBL3405965

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify pos... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_PAM_FLUO8_1536_1X%ACT PRUN

实验名称：Fluorescence polarization-based biochemical high throughput primary assay to identify... 来源：The Scripps Research Institute Molecular Screening Center 靶标：RecName: Full=Sialate O-acetylesterase; AltName: Full=H-Lse; AltName: Full=Sialic acid-specific 9-O-acetylesterase; Flags: Precursor [Homo sapiens] External Id：SIAE_INH_FP_1536_1X%INH PRUN

实验名称：MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Activator_SinglePoint... 来源：Broad Institute 靶标：N/A External Id：2084-01_Activator_SinglePoint_HTS_Activity

实验名称：Counterscreen for inhibitors of the fructose-bisphosphate aldolase (FBA) of M. tuberc... 来源：The Scripps Research Institute Molecular Screening Center 靶标：N/A External Id：GDH-TPI_INH_ABS_1536_1X%INH CSRUN

实验名称：qHTS for Inhibitors of TGF-b: Cytotox Counterscreen 来源：NCGC 靶标：N/A External Id：SMAD3201

实验名称：Inhibition of Staphylococcus aureus USA300 GFP-fused SaeRS at 20 uM after 8 hrs by fl... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4270019

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Xanthoangelol英文别名

• Xanthoangelol
• xanthoangerol
• 2',4,4'-trihydroxy-3'-geranylchalcone
• 3-geranyl-2,4,4'-trihydroxychalcone