盐酸乌拉地尔

• 常用名: 盐酸乌拉地尔
• 英文名: Urapidil Hydrochloride
• CAS号: 64887-14-5
• 分子量: 423.937
• 密度: N/A
• 沸点: 549ºC at 760 mmHg
• 分子式: C₂₀H₃₀ClN₅O₃
• 熔点: 156-158ºC
• 闪点: 285.8ºC
• 符号: GHS07
• 信号词: Warning

盐酸乌拉地尔用途

Urapidil盐酸盐是α1-肾上腺素受体拮抗剂和5-HT1A受体激动剂。

盐酸乌拉地尔名称

• 中文名: 盐酸乌拉地尔
• 英文名: Urapidil Hydrochloride

盐酸乌拉地尔生物活性

• 描述: Urapidil盐酸盐是α1-肾上腺素受体拮抗剂和5-HT1A受体激动剂。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 5-HT受体
  信号通路 >> 神经信号通路 >> 5-HT受体
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 肾上腺素能受体
  研究领域 >> 心血管疾病
• 参考文献:

  [1]. Gross, G., G. Hanft, and N. Kolassa, Urapidil and some analogues with hypotensive properties show high affinities for 5-hydroxytryptamine (5-HT) binding sites of the 5-HT1A subtype and for alpha 1-adrenoceptor binding sites. Naunyn Schmiedebergs Arch Phar

  [2]. Buch, J., Urapidil, a dual-acting antihypertensive agent: Current usage considerations. Adv Ther, 2010. 27(7): p. 426-43.

盐酸乌拉地尔物理化学性质

• 沸点: 549ºC at 760 mmHg
• 熔点: 156-158ºC
• 分子式: C₂₀H₃₀ClN₅O₃
• 分子量: 423.937
• 闪点: 285.8ºC
• 精确质量: 423.203705
• PSA: 71.74000
• LogP: 1.59470
• InChIKey: KTMLZVUAXJERAT-UHFFFAOYSA-N
• SMILES: COc1ccccc1N1CCN(CCCNc2cc(=O)n(C)c(=O)n2C)CC1.Cl
• 外观性状: 白色或灰白色结晶粉末
• 储存条件: Desiccate at RT
• 水溶解性: H2O: soluble

盐酸乌拉地尔安全信息

• 符号: GHS07
• 信号词: Warning
• 危害声明: H302
• 个人防护装备: dust mask type N95 (US);Eyeshields;Gloves
• 危害码 (欧洲): Xn:Harmful;
• 风险声明 (欧洲): R22
• 安全声明 (欧洲): S36
• 危险品运输编码: NONH for all modes of transport
• WGK德国: 3
• RTECS号: YQ9862000
• 海关编码: 3004909090

盐酸乌拉地尔海关

• 海关编码: 3004909090

盐酸乌拉地尔靶点实验

查看更多实验

实验名称：Inhibition of neurosphere proliferation of mouse neural precursor cells by MTT assay 来源：ChEMBL 靶标：N/A External Id：CHEMBL1266185

实验名称：Primary qHTS assay for inhibitors of alpha-synuclein gene (SNCA) expression 来源：NCGC External Id：SNCA-p-activity-luciferase

实验名称：Cytochrome P450 Family 1 Subfamily A Member 2 (CYP1A2) small molecule antagonists: lu... 来源：824 External Id：CYP273

实验名称：Antibacterial activity against Staphylococcus aureus MRSA ATCC 43300 (CO-ADD:GP_020);... 来源：ChEMBL 靶标：Staphylococcus aureus External Id：CHEMBL4296184

实验名称：Antibacterial activity against Klebsiella pneumoniae MDR ATCC 70063 (CO-ADD:GN_003); ... 来源：ChEMBL 靶标：Klebsiella pneumoniae External Id：CHEMBL4296186

实验名称：Antibacterial activity against Escherichia coli ATCC 25922 (CO-ADD:GN_001); MIC in CA... 来源：ChEMBL 靶标：Escherichia coli External Id：CHEMBL4296185

实验名称：Tocris HTS for Inhibitors of Aerobactin Synthetase lucA 来源：23265 External Id：IucA Pilot Assay Tocris Library

实验名称：Dicer-mediated maturation of pre-microRNA 来源：Center for Chemical Genomics, University of Michigan 靶标：N/A External Id：TargetID_659_CEMA

实验名称：p53 small molecule agonists, cell-based qHTS assay: qHTS cell viability counter scree... 来源：824 靶标：N/A External Id：P53600

实验名称：p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes: qHTS ce... 来源：824 靶标：N/A External Id：P53MS958

共332条，当前第1页，共34页

1

2

3

4

5

盐酸乌拉地尔英文别名

• 2,4(1H,3H)-Pyrimidinedione, 6-((3-(4-(2-methoxyphenyl)-1-piperazinyl)propyl)amino)-1,3-dimethyl-, monohydrochloride
• 6-[3-[4-(2-methoxyphenyl)piperazin-1-yl]propylamino]-1,3-dimethylpyrimidine-2,4-dione,hydrochloride
• 6-({3-[4-(2-Methoxyphenyl)piperazin-1-yl]propyl}amino)-1,3-dimethylpyrimidine-2,4(1H,3H)-dione hydrochloride (1:1)
• 2,4(1H,3H)-Pyrimidinedione, 6-[[3-[4-(2-methoxyphenyl)-1-piperazinyl]propyl]amino]-1,3-dimethyl-, hydrochloride (1:1)
• 6-({3-[4-(2-Methoxyphenyl)-1-piperazinyl]propyl}amino)-1,3-dimethyl-2,4(1H,3H)-pyrimidinedione hydrochloride (1:1)