(R)-4-氯-N-(奎宁环-3-基)苯甲酰胺

• 常用名: (R)-4-氯-N-(奎宁环-3-基)苯甲酰胺
• 英文名: PNU 282987
• CAS号: 711085-63-1
• 分子量: 264.75
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₄H₁₇ClN₂O
• 熔点: N/A
• 闪点: N/A

(R)-4-氯-N-(奎宁环-3-基)苯甲酰胺用途

PNU-282987(游离碱)(化合物C7)是一种有效的α7烟碱型乙酰胆碱受体(nAChR)激动剂,EC50为154 nM。PNU-282987(游离碱)也是5-HT3受体的功能性拮抗剂,IC50为4541 nM【1】。

(R)-4-氯-N-(奎宁环-3-基)苯甲酰胺名称

• 中文名: pnu-282987
• 英文名: Benzamide, N-(3R)-1-azabicyclo[2.2.2]oct-3-yl-4-chloro
• 中文别名: N-(3R)-1-氮杂双环[2.2.2]辛-3-基-4-氯-苯甲酰胺

(R)-4-氯-N-(奎宁环-3-基)苯甲酰胺生物活性

• 描述: PNU-282987(游离碱)(化合物C7)是一种有效的α7烟碱型乙酰胆碱受体(nAChR)激动剂,EC50为154 nM。PNU-282987(游离碱)也是5-HT3受体的功能性拮抗剂,IC50为4541 nM【1】。
• 相关类别:
  信号通路 >> 跨膜转运 >> 胆碱受体
  信号通路 >> 神经信号通路 >> 胆碱受体
  研究领域 >> 神经疾病
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 5-HT受体
  信号通路 >> 神经信号通路 >> 5-HT受体
• 靶点实验:

  5-HT3 Receptor

• 参考文献:

  [1]. Bodnar AL, Discovery and structure-activity relationship of quinuclidine benzamides as agonists of alpha7 nicotinic acetylcholine receptors. J Med Chem. 2005 Feb 24;48(4):905-8.

(R)-4-氯-N-(奎宁环-3-基)苯甲酰胺物理化学性质

• 分子式: C₁₄H₁₇ClN₂O
• 分子量: 264.75
• InChIKey: WECKJONDRAUFDD-ZDUSSCGKSA-N
• SMILES: O=C(NC1CN2CCC1CC2)c1ccc(Cl)cc1
• 储存条件: 2-8°C，干燥

(R)-4-氯-N-(奎宁环-3-基)苯甲酰胺安全信息

• 危害码 (欧洲): Xi

(R)-4-氯-N-(奎宁环-3-基)苯甲酰胺靶点实验

查看更多实验

实验名称：Human nicotinic acetylcholine receptor alpha7 subunit (Nicotinic acetylcholine recept... 来源：IUPHAR-DB 靶标：nicotinic acetylcholine receptor alpha7 subunit (Nicotinic acetylcholine receptors) [Homo sapiens] External Id：468_Human

实验名称：Primary qHTS assay for inhibitors of alpha-synuclein gene (SNCA) expression 来源：NCGC External Id：SNCA-p-activity-luciferase

实验名称：Displacement of [125I]alpha-bungarotoxin from alpha7 nAchR in rat frontal cortices 来源：ChEMBL 靶标：Neuronal acetylcholine receptor subunit alpha-7 External Id：CHEMBL3748597

实验名称：Tocris HTS for Inhibitors of Aerobactin Synthetase lucA 来源：23265 External Id：IucA Pilot Assay Tocris Library

实验名称：Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against th... 来源：NCGC 靶标：N/A External Id：s-my-keats_OPM1-m4-1

实验名称：Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against th... 来源：NCGC 靶标：N/A External Id：s-my-OC1MY5-m4-1

实验名称：Primary Screen Inhibitors of CD40 Signaling in BL2 Cells Measured in Cell-Based Syste... 来源：Broad Institute 靶标：N/A External Id：7124-01_Inhibitor_SinglePoint_HTS_Activity

实验名称：Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against th... 来源：NCGC 靶标：N/A External Id：s-my-KMS_34-m4-1

实验名称：Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against th... 来源：NCGC 靶标：N/A External Id：s-my-keats_L363-m4-1

实验名称：Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against th... 来源：NCGC 靶标：N/A External Id：s-my-keats_OCIMY7-m4-1

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(R)-4-氯-N-(奎宁环-3-基)苯甲酰胺英文别名

• MFCD08703110