Oxypeucedanin

Modify Date: 2026-07-03 12:35:00

Oxypeucedanin Structure
Oxypeucedanin structure
Common Name Oxypeucedanin
CAS Number 737-52-0 Molecular Weight 286.279
Density 1.4±0.1 g/cm3 Boiling Point 469.6±45.0 °C at 760 mmHg
Molecular Formula C16H14O5 Melting Point 141-142 °C
MSDS N/A Flash Point 237.8±28.7 °C

 Use of Oxypeucedanin


Oxypeucedanin is a furocoumarin derivative isolated from Angelica dahurica. Oxypeucedanin is a selective open-channel blocker, inhibits the hKv1.5 current with an IC50 value of 76 nM. Oxypeucedanin prolongs cardiac action potential duration (APD), is a potential antiarrhythmic agent for atrial fibrillation[1]. Oxypeucedanin induces cell apoptosis through inhibition of cancer cell migration[2].

 Names

Name oxypeucedanin
Synonym More Synonyms

 Oxypeucedanin Biological Activity

Description Oxypeucedanin is a furocoumarin derivative isolated from Angelica dahurica. Oxypeucedanin is a selective open-channel blocker, inhibits the hKv1.5 current with an IC50 value of 76 nM. Oxypeucedanin prolongs cardiac action potential duration (APD), is a potential antiarrhythmic agent for atrial fibrillation[1]. Oxypeucedanin induces cell apoptosis through inhibition of cancer cell migration[2].
Related Catalog
Target

IC50: HKv1.5 current; apoptosis[1]

References

[1]. Eun JS, et al. Effects of oxypeucedanin on hKv1.5 and action potential duration.Biol Pharm Bull. 2005 Apr;28(4):657-60.

[2]. Yu Liu, et al. Oxypeucedanin hydrate monoacetate isolated from Angelica dahurica induces apoptosis in Caco-2 colon carcinoma cells through the mediation of PI3K-signalling pathway and inhibition of cancer cell migration

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 469.6±45.0 °C at 760 mmHg
Melting Point 141-142 °C
Molecular Formula C16H14O5
Molecular Weight 286.279
Flash Point 237.8±28.7 °C
Exact Mass 286.084137
PSA 65.11000
LogP 2.17
Vapour Pressure 0.0±1.2 mmHg at 25°C
Index of Refraction 1.634
InChIKey QTAGQHZOLRFCBU-UHFFFAOYSA-N
SMILES CC1(C)OC1COc1c2ccoc2cc2oc(=O)ccc12
Storage condition 2-8°C

 Safety Information

Hazard Codes Xi

 Synthetic Route

~86%

Oxypeucedanin Structure

Oxypeucedanin

CAS#:737-52-0

Learn More
Literature: Row; Brown; Stachulski; Lennard Organic and Biomolecular Chemistry, 2006 , vol. 4, # 8 p. 1604 - 1610

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Oxypeucedanin Structure

Oxypeucedanin

CAS#:737-52-0

Learn More
Literature: Organic and Biomolecular Chemistry, , vol. 4, # 8 p. 1604 - 1610

~%

Oxypeucedanin Structure

Oxypeucedanin

CAS#:737-52-0

Learn More
Literature: Organic and Biomolecular Chemistry, , vol. 4, # 8 p. 1604 - 1610

~%

Oxypeucedanin Structure

Oxypeucedanin

CAS#:737-52-0

Learn More
Literature: Organic and Biomolecular Chemistry, , vol. 4, # 8 p. 1604 - 1610

 OxypeucedaninBioassay

View more

Name: Antiproliferative activity against serum-stimulated primary rat aortic VSMC at 30 uM ...
Source: ChEMBL
Target: NON-PROTEIN TARGET
External Id: CHEMBL1817331
Name: Antioxidant activity assessed as inhibition of ferrous chloride-induced lipid peroxid...
Source: ChEMBL
Target: N/A
External Id: CHEMBL4133602
Name: Inhibition of recombinant human CYP1A1 expressed in baker's yeast-derived microsomes ...
Source: ChEMBL
Target: Cytochrome P450 1A1
External Id: CHEMBL4257963
Name: Inhibition of recombinant human BACE1 using Rh-EVNLDAEFK as substrate after 60 mins b...
Source: ChEMBL
Target: Beta-secretase 1
External Id: CHEMBL1936881
Name: Antiausteritic activity against human MIAPaCa2 cells in nutrient-deprived medium meas...
Source: ChEMBL
Target: MIA PaCa-2
External Id: CHEMBL4200159
Name: Antiausteritic activity against human PANC1 cells in nutrient-deprived medium measure...
Source: ChEMBL
Target: PANC-1
External Id: CHEMBL4200158
Name: Larvicidal activity against Aedes aegypti larvae after 24 hrs by TLC bioassay
Source: ChEMBL
Target: Aedes aegypti
External Id: CHEMBL1013844
Name: Cytotoxicity against human PANC1 cells in DMEM measured after 24 hrs by WST8 assay
Source: ChEMBL
Target: PANC-1
External Id: CHEMBL4200161
Name: Antifungal activity against Cladosporium cucumerinum assessed as inhibition of spore ...
Source: ChEMBL
Target: Cladosporium cucumerinum
External Id: CHEMBL1013843
Name: Antiausteritic activity against human PSN1 cells in nutrient-deprived medium measured...
Source: ChEMBL
Target: PSN1
External Id: CHEMBL4200160
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 Synonyms

4-(3,3-Dimethyl-oxiranylmethoxy)-furo[3,2-g]chromen-7-one
5-[(3,3-Dimethyl-2-oxiranyl)methoxy]-7H-furo[3,2-g]chromen-7-one
4-[(3,3-Dimethyl-2-oxiranyl)methoxy]-7H-furo[3,2-g]chromen-7-one
Oxypencedanin
5-[(3,3-Dimethyloxiran-2-yl)methoxy]-7H-furo[3,2-g]chromen-7-one
oxypeucadanin
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