norastemizole

• 常用名: norastemizole
• 英文名: norastemizole
• CAS号: 75970-99-9
• 分子量: 324.40
• 密度: 1.28g/cm3
• 沸点: 519.8ºC at 760 mmHg
• 分子式: C₁₉H₂₁FN₄
• 熔点: N/A
• 闪点: 268.2ºC

norastemizole用途

替卡斯咪唑(Norastemizole)是阿司咪唑的主要代谢产物,是一种有效的选择性H1受体拮抗剂。特卡斯特咪唑具有抗炎活性[1]。

norastemizole名称

• 英文名: 1-[(4-fluorophenyl)methyl]-N-piperidin-4-ylbenzimidazol-2-amine

norastemizole生物活性

• 描述: 替卡斯咪唑(Norastemizole)是阿司咪唑的主要代谢产物,是一种有效的选择性H1受体拮抗剂。特卡斯特咪唑具有抗炎活性[1]。
• 相关类别:
  信号通路 >> 免疫及炎症 >> 组胺受体
  研究领域 >> 炎症/免疫
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 组胺受体
• 参考文献:

  [1]. Lever R, et al. Effect of tecastemizole on pulmonary and cutaneous allergic inflammatory responses. Clin Exp Allergy. 2007 Jun;37(6):909-17.

norastemizole物理化学性质

• 密度: 1.28g/cm3
• 沸点: 519.8ºC at 760 mmHg
• 分子式: C₁₉H₂₁FN₄
• 分子量: 324.40
• 闪点: 268.2ºC
• 精确质量: 324.17500
• PSA: 45.11000
• LogP: 3.13830
• InChIKey: SFOVDSLXFUGAIV-UHFFFAOYSA-N
• SMILES: Fc1ccc(Cn2c(NC3CCNCC3)nc3ccccc32)cc1
• 折射率: 1.658
• 储存条件: 2-8°C

norastemizole靶点实验

查看更多实验

实验名称：Antimalarial activity against Plasmodium falciparum 3D7 infected in ARh+ human erythr... 来源：ChEMBL 靶标：Plasmodium falciparum External Id：CHEMBL4180222

实验名称：Antimalarial activity against Plasmodium falciparum 3D7 infected in ARh+ human erythr... 来源：ChEMBL 靶标：Plasmodium falciparum External Id：CHEMBL4180223

实验名称：Inhibition of human Potassium channel HERG expressed in mammalian cells 来源：ChEMBL 靶标：Potassium voltage-gated channel subfamily H member 2 External Id：CHEMBL766814

实验名称：Antimalarial activity against Plasmodium falciparum 3D7 infected in ARh+ human erythr... 来源：ChEMBL 靶标：Plasmodium falciparum External Id：CHEMBL4180219

实验名称：Antimalarial activity against Plasmodium falciparum 3D7 infected in ARh+ human erythr... 来源：ChEMBL 靶标：Plasmodium falciparum External Id：CHEMBL4180220

实验名称：Antimalarial activity against Plasmodium falciparum 3D7 infected in ARh+ human erythr... 来源：ChEMBL 靶标：Plasmodium falciparum External Id：CHEMBL4180221

实验名称：Inhibition of human ERG expressed in CHO cells by whole cell patch clamp technique 来源：ChEMBL 靶标：Potassium voltage-gated channel subfamily H member 2 External Id：CHEMBL954102

实验名称：Enzymatic assay of human HDAC6 with commercial peptide substrate 来源：ChEMBL 靶标：Histone deacetylase 6 External Id：CHEMBL4808149

实验名称：Enzymatic assay of human HDAC6 with custom peptide substrate 来源：ChEMBL 靶标：Histone deacetylase 6 External Id：CHEMBL4808150

实验名称：Inhibition of human ERG channel in HEK293 cells by voltage-clamp method 来源：ChEMBL 靶标：Potassium voltage-gated channel subfamily H member 2 External Id：CHEMBL1036648

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norastemizole英文别名

• T 1348
• Tetemizole
• Soltara
• Norastemizole