CCT129957

• 常用名: CCT129957
• 英文名: CCT129957
• CAS号: 883098-58-6
• 分子量: 309.32
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₇H₁₅N₃O₃
• 熔点: N/A
• 闪点: N/A

CCT129957用途

CCT129957 是一种吲哚衍生物,也是一种有效的磷脂酶 C-γ (PLC-γ) 抑制剂,IC50 为 ~3 μM,GC50 为 15 μM。CCT129957 以约 15 μM 的浓度抑制鳞状细胞中 Ca2+ 的释放。

CCT129957名称

• 英文名: CCT129957

CCT129957生物活性

• 描述: CCT129957 是一种吲哚衍生物,也是一种有效的磷脂酶 C-γ (PLC-γ) 抑制剂,IC50 为 ~3 μM,GC50 为 15 μM。CCT129957 以约 15 μM 的浓度抑制鳞状细胞中 Ca2+ 的释放。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 代谢酶/蛋白酶 >> 磷脂
• 靶点实验:

  IC50: ~3 μM (Phospholipase C-γ (PLC-γ))[1]

• 体外研究: 左侧的苯基位于由各种氨基酸组成的亲脂囊中。CCT129957的预测结合模式显示了一个稳健的氢键模式以及亲脂接触[1]。CCT129957对肾癌UO-31和乳腺癌T-47D细胞株的生长抑制率约为60-70%[2]。
• 参考文献:

  [1]. Reynisson J, et al. The identification of novel PLC-gamma inhibitors using virtual high throughput screening. Bioorg Med Chem. 2009 Apr 15;17(8):3169-76.

  [2]. Feng L, et al. The effect of PLC-γ2 inhibitors on the growth of human tumour cells. Eur J Med Chem. 2012 Aug;54:463-9.

CCT129957物理化学性质

• 分子式: C₁₇H₁₅N₃O₃
• 分子量: 309.32
• InChIKey: VXDJRTJBOJFUOC-UHFFFAOYSA-N
• SMILES: O=C(NCCc1ccccc1)c1cc2cccc([N+](=O)[O-])c2[nH]1
• 储存条件: 2-8°C，干燥，密封

CCT129957安全信息

• 危害码 (欧洲): Xi

CCT129957靶点实验

查看更多实验

实验名称：Dicer-mediated maturation of pre-microRNA 来源：Center for Chemical Genomics, University of Michigan 靶标：N/A External Id：TargetID_659_CEMA

实验名称：Inhibition of phospholipase C gamma2 in human A431 cells assessed as reduction of cal... 来源：ChEMBL 靶标：1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 External Id：CHEMBL1018875

实验名称：Inhibition of recombinant phospholipase C gamma2 expressed in baculovirus infected Sf... 来源：ChEMBL 靶标：1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 External Id：CHEMBL1018873

实验名称：Cytotoxicity against human HCT116 cells assessed as cellular growth at 10 uM by SRB a... 来源：ChEMBL 靶标：HCT-116 External Id：CHEMBL2215875

实验名称：Cytotoxicity against human HCC2998 cells assessed as cellular growth at 10 uM by SRB ... 来源：ChEMBL 靶标：HCC 2998 External Id：CHEMBL2215876

实验名称：Cytotoxicity against human HCT15 cells assessed as cellular growth at 10 uM by SRB as... 来源：ChEMBL 靶标：HCT-15 External Id：CHEMBL2215874

实验名称：Cytotoxicity against human SR cells assessed as cellular growth at 10 uM by SRB assay 来源：ChEMBL 靶标：SR External Id：CHEMBL2215887

实验名称：Cytotoxicity against human MOLT4 cells assessed as cellular growth at 10 uM by SRB as... 来源：ChEMBL 靶标：MOLT-4 External Id：CHEMBL2215888

实验名称：Cytotoxicity against human HOP62 cells assessed as cellular growth at 10 uM by SRB as... 来源：ChEMBL 靶标：HOP-62 External Id：CHEMBL2215885

实验名称：Cytotoxicity against human A549 cells assessed as cellular growth at 10 uM by SRB ass... 来源：ChEMBL 靶标：A549 External Id：CHEMBL2215886

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