ML-SI3

• 常用名: ML-SI3
• 英文名: ML-SI3
• CAS号: 891016-02-7
• 分子量: 429.576
• 密度: 1.3±0.1 g/cm3
• 沸点: 589.3±60.0 °C at 760 mmHg
• 分子式: C₂₃H₃₁N₃O₃S
• 熔点: N/A
• 闪点: 310.2±32.9 °C

ML-SI3用途

ML-SI3是一种TRPML通道抑制剂。ML-SI3阻断TRPML1和TRPML2,IC50分别为4.7µM和1.7µM。ML-SI3阻止溶酶体钙流出并阻断下游TRPML1介导的自噬诱导[1][5]。

ML-SI3名称

• 英文名: N-{2-[4-(2-Methoxyphenyl)-1-piperazinyl]cyclohexyl}benzenesulfonamide

ML-SI3生物活性

• 描述: ML-SI3是一种TRPML通道抑制剂。ML-SI3阻断TRPML1和TRPML2,IC50分别为4.7µM和1.7µM。ML-SI3阻止溶酶体钙流出并阻断下游TRPML1介导的自噬诱导[1][5]。
• 相关类别:
  信号通路 >> 跨膜转运 >> TRP频道
  研究领域 >> 心血管疾病
  研究领域 >> 神经疾病
• 靶点实验:

  TRPML1:4.7 μM (IC50)

  TRPML2:1.7 μM (IC50)

  TRPML3:12.5 μM (IC50)

• 体外研究: ML-SI3(10μM)抑制HeLa细胞中ML-SA1诱发的Ca2+信号[2]。ML-SI3(25-75μM,24h)破坏了成年血吸虫的体表完整性[3]。ML-SI3(10μM)阻断雷帕霉素(HY-10219)诱导的ITRPML1模拟溶酶体管腔[4]。ML-SI3(3µM,6 h)消除了新生大鼠心室肌细胞(NRVM)中缺氧/复氧(h/R)(4 h h/2 h R)诱导的LC3II和p62水平的增加[5]。
• 体内研究: ML-SI3(1.5 mg/kg,i.p.,4次)减轻小鼠心肌细胞的i/R损伤[5]。动物模型：心肌缺血/再灌注(I/R)损伤小鼠[5]剂量：1.5 mg/kg给药：腹腔注射(I.p.),在体内I/R(缺血30分钟和再灌注1天)之前和期间四次。

ML-SI3物理化学性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 589.3±60.0 °C at 760 mmHg
• 分子式: C₂₃H₃₁N₃O₃S
• 分子量: 429.576
• 闪点: 310.2±32.9 °C
• 精确质量: 429.208618
• LogP: 4.00
• InChIKey: OVTXOMMQHRIKGL-UHFFFAOYSA-N
• SMILES: COc1ccccc1N1CCN(C2CCCCC2NS(=O)(=O)c2ccccc2)CC1
• 蒸汽压: 0.0±1.7 mmHg at 25°C
• 折射率: 1.629
• 储存条件: -20°C

ML-SI3安全信息

• 危害码 (欧洲): Xi

ML-SI3靶点实验

查看更多实验

实验名称：Primary cell-based high-throughput screening assay for identification of compounds th... 来源：Johns Hopkins Ion Channel Center 靶标：regulator of G-protein signaling 4 isoform 2 [Homo sapiens] External Id：JHICC_RGS_Act_HTS

实验名称：NCATS Kinetic Aqueous Solubility Profiling 来源：NCGC 靶标：N/A External Id：ADME-solubility1

实验名称：Luminescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：mu-type opioid receptor isoform MOR-1 [Homo sapiens] External Id：OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN

实验名称：QFRET-based biochemical primary high throughput screening assay to identify exosite i... 来源：The Scripps Research Institute Molecular Screening Center 靶标：disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] External Id：ADAM17_INH_QFRET_1536_1X%INH PRUN

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：uHTS identification of small molecule activators of the adaptive arm of the Unfolded ... 来源：Burnham Center for Chemical Genomics 靶标：N/A External Id：BCCG-A405-UPR-XBP1-PrimaryAgonist-Assay

实验名称：Fluorescence polarization to screen for inhibitor that competite the binding of FadD2... 来源：Broad Institute 靶标：FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE) External Id：2147-01_Inhibitor_SinglePoint_HTS_Activity

实验名称：Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfect... 来源：Broad Institute 靶标：N/A External Id：Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfected HEK293 cells Inhibition - 7011-01_Antagonist_SinglePoint_HTS_Activity

实验名称：NCATS Parallel Artificial Membrane Permeability Assay (PAMPA) Profiling 来源：NCGC 靶标：N/A External Id：ADME-PAMPA1

实验名称：Primary Screen Inhibitors of CD40 Signaling in BL2 Cells Measured in Cell-Based Syste... 来源：Broad Institute 靶标：N/A External Id：7124-01_Inhibitor_SinglePoint_HTS_Activity

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ML-SI3英文别名

• MFCD14811190
• N-{2-[4-(2-Methoxyphenyl)-1-piperazinyl]cyclohexyl}benzenesulfonamide
• ML-SI3