洛贝林

Q: 洛贝林的分子量是多少？

洛贝林分子量为337.455。

更新时间：2026-07-16 18:53:30

洛贝林结构式	常用名	洛贝林	英文名	(-)-Lobeline
	CAS号	90-69-7	分子量	337.455
	密度	1.1±0.1 g/cm3	沸点	485.6±15.0 °C at 760 mmHg
	分子式	C₂₂H₂₇NO₂	熔点	130-131°
	MSDS	N/A	闪点	247.5±20.4 °C

洛贝林用途

洛贝林(α-洛贝林；L-洛贝林)是一种亲脂性生物碱,是一种烟碱受体激动剂。洛贝林抑制d-甲基苯丙胺自我给药,无多巴胺毒性。洛贝琳挽救了滥用d-苯丙胺导致的成瘾效应。洛贝林通过抑制DA摄取到突触小泡中并改变突触前DA储存来增加多巴胺(DA)释放[1][2][3]。

本表展示该化学物质的中文名称、英文系统名、各类中文与英文别名信息。

中文名	洛贝林
英文名	(-)-lobeline
英文别名	更多

本表记录该化合物相关生物活性、作用靶点、活性说明与生物实验相关数据。

描述	洛贝林(α-洛贝林；L-洛贝林)是一种亲脂性生物碱,是一种烟碱受体激动剂。洛贝林抑制d-甲基苯丙胺自我给药,无多巴胺毒性。洛贝琳挽救了滥用d-苯丙胺导致的成瘾效应。洛贝林通过抑制DA摄取到突触小泡中并改变突触前DA储存来增加多巴胺(DA)释放[1][2][3]。
相关类别	信号通路 >> 跨膜转运 >> 胆碱受体信号通路 >> 神经信号通路 >> 胆碱受体信号通路 >> 神经信号通路 >> 多巴胺转运蛋白研究领域 >> 神经疾病
体外研究	洛贝林(0.1-100μM)诱导 [3H]天溢出呈非钙依赖性[1]。洛贝琳牌手表抑制 [3H]天被突触小体 (IC50=80μM)和囊泡 (IC50=0.88μM)摄取[1]。洛贝林(0.1-1μM；1小时)抑制 1μM d-甲基苯丙胺诱导的纹状体切片释放多巴胺[2]。
体内研究	洛贝林(0.3-3.0 mg/kg；皮下注射; 单剂量) 降低模型大鼠 d-去氧麻黄碱的自我给药能力[3]。洛贝林(3 mg/kg；皮下注射; 7.个周期,共 7.次) 以非竞争性的方式特别降低大鼠对 d-去氧麻黄碱的反应,并增加耐受性发展[3]。动物模型：Sprague-Dawley大鼠(200-250 g)[3]剂量：0.3 mg/kg、1.0 mg/kg和3.0 mg/kg用于急性给药；慢性给药3 mg/kg给药：皮下注射；测量前15分钟,或每15分钟进行7次；间隔2个干预维持日的d-甲基苯丙胺(0.05 mg/kg输注)自我给药结果：d-甲基苯甲酯自我给药减少。
参考文献	[1]. Teng L, et al. Lobeline and nicotine evoke [3H]overflow from rat striatal slices preloaded with [3H]dopamine: differential inhibition of synaptosomal and vesicular [3H]dopamine uptake. J Pharmacol Exp Ther. 1997 Mar;280(3):1432-44. [2]. Miller DK, et al. Lobeline inhibits the neurochemical and behavioral effects of amphetamine. J Pharmacol Exp Ther. 2001 Mar;296(3):1023-34. [3]. Harrod SB, et al. Lobeline attenuates d-methamphetamine self-administration in rats. J Pharmacol Exp Ther. 2001 Jul;298(1):172-9.

本表包含该物质理化参数，如熔点、沸点、密度、溶解度、旋光性等理化指标，无数据项标记为N/A。

密度	1.1±0.1 g/cm3
沸点	485.6±15.0 °C at 760 mmHg
熔点	130-131°
分子式	C₂₂H₂₇NO₂
分子量	337.455
闪点	247.5±20.4 °C
精确质量	337.204193
PSA	40.54000
LogP	3.61
InChIKey	MXYUKLILVYORSK-HKBOAZHASA-N
SMILES	CN1C(CC(=O)c2ccccc2)CCCC1CC(O)c1ccccc1
蒸汽压	0.0±1.3 mmHg at 25°C
折射率	1.563
储存条件	库房低温通风干燥,与食品原料分开存放

本表为化学品安全说明书MSDS数据，包含危险标识、成分、急救、消防、泄漏处置、操作储存等安全信息。

Date Updated: 13/FEB/2006
Version 1.2
Regulation (EC) No 1907/2006
________________________________________________________________________
1 - Product and Company Information
________________________________________________________________________

Product NameL-LOBELINE FREE BASE
Product NumberL7149
Company
Century Ba-Shi Building 22A-B,
200020 Shanghai
Technical Phone #86-21-61415566
Fax 86-21-61415567
E-mail Address
________________________________________________________________________
2 - Hazards Identification
________________________________________________________________________
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Toxic by inhalation, in contact with skin and if swallowed.
________________________________________________________________________
3 - Composition/Information on Ingredients
________________________________________________________________________
Product NameCAS #EC noAnnex I
Index Number
L-LOBELINE FREE BASE90-69-7202-012-3 None
FormulaC22H27NO2
Molecular Weight 337,5000 AMU
Synonyms8,10-Diphenyllobelionol *
2-(6-(beta-Hydroxy-phenethyl)-1-methyl-2-piperidy
l)acetophenone *
2-(6-(2-Hydroxy-2-phenylethyl)-1-methyl-2-piperid
inyl)-1-phenylethanone * Inflatine * Lobelin *
(-)-Lobeline * alpha-Lobeline * Lobnico
________________________________________________________________________
4 - First Aid Measures
________________________________________________________________________
AFTER INHALATION
If inhaled, remove to fresh air. If breathing becomes difficult,
call a physician.
AFTER SKIN CONTACT
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
AFTER EYE CONTACT
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.
________________________________________________________________________
5 - Fire Fighting Measures
________________________________________________________________________
EXTINGUISHING MEDIA
Suitable: Carbon dioxide, dry chemical powder, or appropriate
foam.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
________________________________________________________________________
6 - Accidental Release Measures
________________________________________________________________________
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear respirator, chemical safety goggles, rubber boots, and
heavy rubber gloves.
METHODS FOR CLEANING UP
Sweep up, place in a bag and hold for waste disposal. Avoid
raising dust. Ventilate area and wash spill site after material
pickup is complete.
________________________________________________________________________
7 - Handling and Storage
________________________________________________________________________
________________________________________________________________________
8 - Exposure Controls / Personal Protection
________________________________________________________________________
ENGINEERING CONTROLS
Mechanical exhaust.
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Use respirators and components tested and
approved under appropriate government standards such as NIOSH (US)
or CEN (EU). Where risk assessment shows air-purifying respirators
are appropriate use a full-face particle respirator type N99 (US)
or type P2 (EN 143) respirator cartridges as a backup to
engineering controls. If the respirator is the sole means of
protection, use a full-face supplied air respirator.
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.
________________________________________________________________________
9 - Physical and Chemical Properties
________________________________________________________________________
AppearancePhysical State: Solid
PropertyValueAt Temperature or Pressure
pHN/A
BP/BP RangeN/A
MP/MP RangeN/A
Flash PointN/A
FlammabilityN/A
Autoignition TempN/A
Oxidizing PropertiesN/A
Explosive PropertiesN/A
Explosion LimitsN/A
Vapor PressureN/A
Partition CoefficientN/A
ViscosityN/A
Vapor DensityN/A
Saturated Vapor Conc. N/A
Evaporation RateN/A
Bulk DensityN/A
Decomposition Temp.N/A
Solvent ContentN/A
Water ContentN/A
Surface TensionN/A
ConductivityN/A
Miscellaneous DataN/A
SolubilityN/A
________________________________________________________________________
10 - Stability and Reactivity
________________________________________________________________________
STABILITY
Stable: Stable.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide,
Nitrogen oxides.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
________________________________________________________________________
11 - Toxicological Information
________________________________________________________________________
RTECS NUMBER: OJ8480000
ACUTE TOXICITY
LD50
Intraperitoneal
Mouse
43500 UG/KG
LD50
Intravenous
Mouse
6300 UG/KG
LD50
Subcutaneous
Rabbit
35 MG/KG
SIGNS AND SYMPTOMS OF EXPOSURE
Stomach pains, vomiting, diarrhea. Exposure can cause:
ROUTE OF EXPOSURE
Multiple Routes: Harmful if swallowed, inhaled, or absorbed
through skin. May cause irritation.
TARGET ORGAN INFORMATION
Central nervous system. Peripheral nervous system.
________________________________________________________________________
12 - Ecological Information
________________________________________________________________________
No data available.
________________________________________________________________________
13 - Disposal Considerations
________________________________________________________________________
SUBSTANCE DISPOSAL
Dissolve or mix the material with a combustible solvent and burn
in a chemical incinerator equipped with an afterburner and
scrubber. Observe all federal, state, and local environmental
regulations.
________________________________________________________________________
14 - Transport Information
________________________________________________________________________
RID/ADR
UN#: 1544
Class: 6.1
PG: III
Proper Shipping Name: Alkaloids, solid, n.o.s.
IMDG
UN#: 1544
Class: 6.1
PG: III
Proper Shipping Name: Alkaloids, solid, n.o.s.
Marine Pollutant: No
Severe Marine Pollutant: No
Technical Name: Required
IATA
UN#: 1544
Class: 6.1
PG: III
Proper Shipping Name: Alkaloids, solid, n.o.s.
Inhalation Packing Group I: No
Technical Name: Required
________________________________________________________________________
15 - Regulatory Information
________________________________________________________________________
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
INDICATION OF DANGER: T
Toxic.
R-PHRASES: 23/24/25
Toxic by inhalation, in contact with skin and if swallowed.
S-PHRASES: 36/37/39-45
Wear suitable protective clothing, gloves, and eye/face
protection. In case of accident or if you feel unwell, seek
medical advice immediately (show the label where possible).
COUNTRY SPECIFIC INFORMATION
Germany
WGK: 3
Self-Classification
________________________________________________________________________
16 - Other Information
________________________________________________________________________
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
unlimitedpaper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.

模块 15 - 法规信息
N/A

模块16 - 其他信息
N/A

本表汇总该化学品毒理试验数据、急性慢性毒性以及环境生态危害相关参数。

洛贝林毒性英文版

本表记录该化合物安全警示、防护措施、禁配物、处置方式等安全相关参考信息。

危害码 (欧洲)	T
风险声明 (欧洲)	23/24/25
安全声明 (欧洲)	36/37/39-45
危险品运输编码	UN 1544
包装等级	III
危险类别	6.1(b)

本表提供该化合物公开报道的合成路线、反应条件、反应物与产物参考信息。

本表列出该化学品对应的上游起始原料以及下游衍生产物清单。

洛贝林上游产品 8
CAS号134-63-4 盐酸洛贝林 CAS号6919-61-5 N-甲基-N-甲基苯甲酰胺 CAS号6249-80-5 4-Phenyl-1-bute... CAS号80735-94-0 1-苯基-3-丁烯-1-醇
CAS号85551-57-1 (αR)-α-(2-prope... CAS号423763-79-5 (1R,3S)-2-oxira... CAS号423763-78-4 (4S,6R)-4-iodom... CAS号423763-77-3 tert-butyl [(1R...
洛贝林下游产品 0

本表记录该化合物靶点、体外体内实验、生物测定实验相关实验数据。

实验名称：Primary qHTS assay for inhibitors of alpha-synuclein gene (SNCA) expression
来源：NCGC
External Id：SNCA-p-activity-luciferase

实验名称：Inhibition constant against [3H]nicotine binding to vesicular monoamine transporter-2...
来源：ChEMBL
靶标：Synaptic vesicular amine transporter
External Id：CHEMBL882463

实验名称：Half life in Sprague-Dawley rat plasma
来源：ChEMBL
靶标：N/A
External Id：CHEMBL4186327

实验名称：Inhibition constant against [3H]methyllycaconitine binding to vesicular monoamine tra...
来源：ChEMBL
靶标：Synaptic vesicular amine transporter
External Id：CHEMBL885371

实验名称：Inhibition constant against [3H]dihydrotetrabenazine binding to vesicular monoamine t...
来源：ChEMBL
靶标：Synaptic vesicular amine transporter
External Id：CHEMBL885370

实验名称：qHTS Assay for Small Molecule Inhibitors of the Human hERG Channel Activity
来源：NCGC
External Id：HERG01

实验名称：Antiviral activity against SARS-CoV-2 infected in HEK293T cells expressing ACE2/TMPRS...
来源：ChEMBL
靶标：Severe acute respiratory syndrome coronavirus 2
External Id：CHEMBL5259379

实验名称：qHTS for Inhibitors of TGF-b: Cytotox Counterscreen
来源：NCGC
靶标：N/A
External Id：SMAD3201

实验名称：qHTS for Inhibitors of ATXN expression: Validation of Cytotoxic Assay
来源：NCGC
靶标：N/A
External Id：SCA2002

实验名称：qHTS for Inhibitors of TGF-b
来源：NCGC
靶标：Smad3 [Homo sapiens]
External Id：SMAD3101

共234条，当前第1页，共24页

本表罗列该化合物全部英文别名、系统命名、CAS别名等英文名称集合。

[2R-[2a,6a(S*)]]-2-[6-(2-Hydroxy-2-phenylethyl)-1-methyl-2-piperidinyl]-1-phenylethanone

2-{(2R,6S)-6-[(2S)-2-Hydroxy-2-phenylethyl]-1-methylpiperidin-2-yl}-1-phenylethanone

2-{(2R,6S)-6-[(2S)-2-Hydroxy-2-phenylethyl]-1-methyl-2-piperidinyl}-1-phenylethanone

lobeline

Lobron

Bantron

Inflatine

2-[(2R,6S)-6-[(2S)-2-hydroxy-2-phenylethyl]-1-methylpiperidin-2-yl]-1-phenylethanone

Zoolobelin

Lobelina

本部分为该化合物相关常见问答，包含基础参数、性状、储存条件等高频咨询问题与对应答案。

Q: 洛贝林的安全信息是什么？

A: 洛贝林安全信息：36/37/39-45。

Q: 洛贝林有什么用途？

A: 洛贝林主要用途：洛贝林(α-洛贝林；L-洛贝林)是一种亲脂性生物碱,是一种烟碱受体激动剂。洛贝林抑制d-甲基苯丙胺自我给药,无多巴胺毒性。洛贝琳挽救了滥用d-苯丙胺导致的成瘾效应。洛贝林通过抑制DA摄取到突触小泡中并改变突触前DA储存来增加多巴胺(DA)释放[1][2][3]。

Q: 洛贝林的英文名称是什么？

A: 洛贝林英文名称为(-)-lobeline。

Q: 洛贝林的InChIKey是什么？

A: 洛贝林InChIKey为MXYUKLILVYORSK-HKBOAZHASA-N。

Q: 洛贝林的极性表面积PSA是多少？

A: 洛贝林极性表面积PSA为40.54000。

Q: 洛贝林的熔点是多少？

A: 洛贝林熔点为130-131°。

Q: 洛贝林的分子量是多少？

A: 洛贝林分子量为337.455。

Q: 洛贝林的LogP（油水分配系数）是多少？

A: 洛贝林LogP（油水分配系数）为3.61。

Q: 洛贝林有哪些英文别名？

A: 洛贝林英文别名有：[2R-[2a,6a(S*)]]-2-[6-(2-Hydroxy-2-phenylethyl)-1-methyl-2-piperidinyl]-1-phenylethanone、2-{(2R,6S)-6-[(2S)-2-Hydroxy-2-phenylethyl]-1-methylpiperidin-2-yl}-1-phenylethanone、2-{(2R,6S)-6-[(2S)-2-Hydroxy-2-phenylethyl]-1-methyl-2-piperidinyl}-1-phenylethanone、lobeline、Lobron、Bantron、Inflatine、2-[(2R,6S)-6-[(2S)-2-hydroxy-2-phenylethyl]-1-methylpiperidin-2-yl]-1-phenylethanone、Zoolobelin、Lobelina。

Q: 洛贝林的上游原料有哪些？

A: 洛贝林相关上游原料（CAS）：134-63-4;6919-61-5;6249-80-5;80735-94-0;85551-57-1;423763-79-5;423763-78-4;423763-77-3。

本表列出该化合物相关生产厂商、供应商信息，包含厂家名称、产品供应相关参考信息。

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