95635-55-5

• 常用中文名：雷诺嗪
• 常用英文名：Ranolazine
• CAS号：95635-55-5
• 分子式：C₂₄H₃₃N₃O₄
• 分子量：427.536
• 相关类别： 生物化工 抑制剂 跨膜转运体(Transmembrane Transporters) Calcium Channel 抑制剂
• 发布时间：2018-05-09 08:00:00
• 更新时间：2026-07-28 19:00:38
• Ranolazine具有抗心律失常活性。

名称

• 中文名: 雷诺嗪
• 英文名: Ranolazine
• 中文别名: 雷诺嗪(RANOLAZINE); 雷诺嗪杂质; 雷诺嗪碱; 雷诺嗪,10 MM DMSO 溶液; N-(2,6-二甲基苯基)-4-[2-羟基-3-(2-甲氧苯氧基)丙基]-1-哌嗪乙酰胺; 雷诺嗪-D5; N-(2,6-二甲基苯基)-2-(4-(2-羟基-3-(2-甲氧基苯氧基)丙基)哌嗪-1-基)乙酰胺; Ranolazine 10mM * 1mL in DMSO试剂; 1-[3-(2-甲氧苯氧基)-2-羟丙基]-4-[(2,6-二甲基乙酰)苯胺]哌嗪(雷诺嗪游离碱); 雷诺嗪 标准品; 雷诺拉嗪D5; 雷诺嗪相关杂质
• 英文别名: (±)-1-[3-(2-Methoxyphenoxy)-2-hydroxypropyl]-4-[N-(2,6-dimethylphenyl)carbamoylmethyl]piperazine; RAN D; Renexa; N-(2,6-diMethylphenyl)-2-{4-[(2R)-2-hydroxy-3-(2-Methoxyphenoxy)propyl]piperazin-1-yl}acetaMide; 1-Piperazineacetamide,N-(2,6-dimethylphenyl)-4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]; Ranolazine(Ranexa); (±)-4-[2-Hydroxy-3-(o-methoxyphenoxy)propyl]-1-piperazineaceto-2',6'-xylidide; 1-[3-(2-methoxyphenoxy)-2-hydroxypropyl]-4-[(2,6-dimethylphenyl)aminocarbonylmethy]piperazine; N-(2,6-dimethylphenyl)-4-[2-hydroxy-3-(2-methoxyphenoxy)-propyl]-1-piperazineacetamide; 1-[3-(2-methoxyphenoxy)-2-hydroxypropyl]-4-[(2,6,dimethylphenyl)-aminocarbonylmethyl]-piperazine; RS 43; Ranolazine - Bio-X; Ranexa; 1-[3-(2-methoxyphenoxy)-2-hydroxypropyl]-4-[(2,6-dimethylphenyl)aminocbonylmethy]piperazine; Ranolazine N-(2,6-Dimethylphenyl)-2-[4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]piperazin-1-yl]acetamide; n-(2,6-dimethylphenyl)-2-[4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]piperazin-1-yl]acetamide; (±)-N-(2,6-Dimethylphenyl)-4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]-1-piperazineacetamide; Renault oxazine; N-(2,6-Dimethylphenyl)-2-{4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]piperazin-1-yl}acetamid; CVT 303; N-(2,6-diméthylphényl)-2-{4-[2-hydroxy-3-(2-méthoxyphénoxy)propyl]pipérazin-1-yl}acétamide; Ranolazine N-(2,6-Dimethylphenyl)-4-[2-hydroxy-3-(2- methoxyphenoxy)propyl]-1-piperazineacetamide; Ranolazine, min; RANOLAZINE (NON-STERILE BULK DRUG SUBSTANCE); N-(2,6-Dimethylphenyl)-2-{4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]-1-piperazinyl}acetamide; [14C]-Ranolazine; (142-3) ranolazine; Ran4; MFCD00864690; Ranolazine, 10 mM in DMSO; RANOLAZINE; Ranolazine (CVT303, RS43285-003; 1- 3-(2-Methoxyphenoxy)-2-hydroxypropyl -4; N-(2,6-dimethylphenyl)-2-[4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]piperazin-1-yl]ethanamide; Renozine; N-(2,6-Dimethylphenyl)-2-{4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]piperazin-1-yl}acetamide

物化性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 624.1±55.0 °C at 760 mmHg
• 熔点: 119-1200C
• 分子式: C₂₄H₃₃N₃O₄
• 分子量: 427.536
• 闪点: 331.2±31.5 °C
• 精确质量: 427.247101
• PSA: 74.27000
• LogP: 3.47
• 外观性状: 白色固体
• 蒸汽压: 0.0±1.9 mmHg at 25°C
• 折射率: 1.586
• 储存条件: -20°C Freezer

生物活性

• 描述: Ranolazine具有抗心律失常活性。
• 相关类别:
  信号通路 >> 跨膜转运 >> 钙通道
  信号通路 >> 跨膜转运 >> 钠通道
  研究领域 >> 心血管疾病
  天然产物 >> 其他
• 参考文献:

  [1]. Hale, S.L. and R.A. Kloner, Ranolazine, an inhibitor of the late sodium channel current, reduces postischemic myocardial dysfunction in the rabbit. J Cardiovasc Pharmacol Ther, 2006. 11(4): p. 249-55.

  [2]. Fraser, H., et al., Ranolazine decreases diastolic calcium accumulation caused by ATX-II or ischemia in rat hearts. J Mol Cell Cardiol, 2006. 41(6): p. 1031-8.

  [3]. Gould, H.J., 3rd, et al., Ranolazine attenuates behavioral signs of neuropathic pain. Behav Pharmacol, 2009. 20(8): p. 755-8.

  [4]. Casey, G.P., et al., Ranolazine attenuation of CFA-induced mechanical hyperalgesia. Pain Med, 2010. 11(1): p. 119-26.

安全

• 危害码 (欧洲): Xi
• 危险品运输编码: UN 2811 6.1 / PGIII
• 海关编码: 2933990090

合成路线

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海关

海关编码	2933990090
中文概述	2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%