N-(2,6-二甲基苯基)-2-(4-(2-羟基-3-(2-甲氧基苯氧基)-丙基)哌嗪-1-基)乙酰胺 二盐酸盐

• 常用名: N-(2,6-二甲基苯基)-2-(4-(2-羟基-3-(2-甲氧基苯氧基)-丙基)哌嗪-1-基)乙酰胺 二盐酸盐
• 英文名: Ranolazine dihydrochloride
• CAS号: 95635-56-6
• 分子量: 500.458
• 密度: N/A
• 沸点: 624.1ºC at 760 mmHg
• 分子式: C₂₄H₃₅Cl₂N₃O₄
• 熔点: 222-229.5ºC(lit.)
• 闪点: N/A

用途

Ranolazine双盐酸盐具有抗心律失常活性。

名称

• 中文名: 盐酸雷诺嗪
• 英文名: Ranolazine dihydrochloride
• 中文别名: 雷诺嗪盐酸盐 | N-(2,6-二甲基苯基)-4-[2-羟基-3-(2-甲氧苯氧基)丙基]-1-哌嗪乙酰胺盐酸盐 | 雷喏嗪

生物活性

• 描述: Ranolazine双盐酸盐具有抗心律失常活性。
• 相关类别:
  信号通路 >> 自噬 >> 自噬
  信号通路 >> 跨膜转运 >> 钙通道
  信号通路 >> 跨膜转运 >> 钠通道
  研究领域 >> 心血管疾病
• 参考文献:

  [1]. Hawwa N, Menon V. Ranolazine: Clinical Applications and Therapeutic Basis. Am J Cardiovasc Drugs. 2013 Jan 19.

  [2]. Keating GM. Ranolazine: A Review of Its Use as Add-On Therapy in Patients with Chronic Stable Angina Pectoris. Drugs. 2013 Jan;73(1):55-73.

  [3]. Wang WQ, Robertson C, Dhalla AK, Belardinelli L. Antitorsadogenic effects of ({+/-})-N-(2,6-dimethyl-phenyl)-(4[2-hydroxy-3-(2-methoxyphenoxy)propyl]-1-piperazine (ranolazine) in anesthetized rabbits. J Pharmacol Exp Ther. 2008 Jun;325(3):875-81. doi: 10.1124/jpet.108.137729. Epub 2008 Mar 5.

  [4]. Shryock JC, Belardinelli L. Inhibition of late sodium current to reduce electrical and mechanical dysfunction of ischaemic myocardium. Br J Pharmacol. 2008 Mar;153(6):1128-32. Epub 2007 Dec 10.

  [5]. Zacharowski K, Blackburn B, Thiemermann C. Ranolazine, a partial fatty acid oxidation inhibitor, reduces myocardial infarct size and cardiac troponin T release in the rat. Eur J Pharmacol. 2001 Apr 20;418(1-2):105-10.

物理化学性质

• 沸点: 624.1ºC at 760 mmHg
• 熔点: 222-229.5ºC(lit.)
• 分子式: C₂₄H₃₅Cl₂N₃O₄
• 分子量: 500.458
• 精确质量: 499.200470
• PSA: 74.27000
• LogP: 3.86080
• InChIKey: RJNSNFZXAZXOFX-UHFFFAOYSA-N
• SMILES: COc1ccccc1OCC(O)CN1CCN(CC(=O)Nc2c(C)cccc2C)CC1.Cl.Cl
• 外观性状: solid | off-white
• 储存条件: Desiccate at RT
• 水溶解性: H2O: 10 mg/mL, soluble

安全信息

• 个人防护装备: Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
• 安全声明 (欧洲): S22-S24/25
• 危险品运输编码: NONH for all modes of transport
• WGK德国: 3
• 海关编码: 2942000000

海关

• 海关编码: 2942000000

靶点实验

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英文别名

• Ranolazine dihydrochloride
• RANOLAZINE HCL
• MFCD03788770
• RANOLAZINE DI HCL
• Ranolazine (dihydrochloride)
• N-(2,6-Dimethylphenyl)-2-{4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]-1-piperazinyl}acetamide dihydrochloride
• Ranolazine DiHCI
• Ranolazine and salt
• 1-Piperazineacetamide, N-(2,6-dimethylphenyl)-4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]-, hydrochloride (1:2)
• Ranolazine Dihydrocloride
• Ranolazine 2HCl
• N-(2,6-Dimethylphenyl)-2-{4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]piperazin-1-yl}acetamide dihydrochloride
• Ranolazine dihydroch