Cirazoline hydrochloride
Cirazoline hydrochloride structure
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Common Name | Cirazoline hydrochloride | ||
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| CAS Number | 40600-13-3 | Molecular Weight | 252.74000 | |
| Density | 1.25g/cm3 | Boiling Point | 409.5ºC at 760mmHg | |
| Molecular Formula | C13H17ClN2O | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 201.4ºC | |
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The contribution of d-tubocurarine-sensitive and apamin-sensitive K-channels to EDHF-mediated relaxation of mesenteric arteries from eNOS-/- mice.
J. Cardiovasc. Pharmacol. 59(5) , 413-25, (2012) The nature of the potassium channels involved in determining endothelium-derived hyperpolarizing factor-mediated relaxation was investigated in first-order small mesenteric arteries from male endothelial nitric oxide synthase (eNOS-/-)-knockout and control (+... |
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Different response of ANP secretion to adrenoceptor stimulation in renal hypertensive rat atria.
Peptides 29(7) , 1207-15, (2008) Sympathetic nervous system and atrial natriuretic peptide (ANP) system play fundamental roles in the regulation of cardiovascular functions. Overactivity of sympathetic nervous system can lead into cardiovascular diseases such as heart failure and hypertensio... |
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Attenuation of store-operated Ca2+ entry and enhanced expression of TRPC channels in caudal artery smooth muscle from Type 2 diabetic Goto-Kakizaki rats.
Clin. Exp. Pharmacol. Physiol. 37(7) , 670-8, (2010) 1. Previously, we found that Ca(2+) entry from the extracellular space via alpha(1)-adrenoceptor-activated, Ca(2+)-permeable channels, but not voltage-gated Ca(2+) channels, is impaired in endothelium-denuded caudal artery smooth muscle from Type 2 diabetic G... |
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Impairment of α1-adrenoceptor-mediated contractile activity in caudal arterial smooth muscle from type 2 diabetic Goto-Kakizaki rats.
Clin. Exp. Pharmacol. Physiol. 37(3) , 350-7, (2010) 1. In the present study, we compared the responsiveness of de-endothelialized caudal artery smooth muscle strips, isolated from Type 2 diabetic Goto-Kakizaki (GK) and normal Wistar rats, to alpha(1)-adrenoceptor stimulation (cirazoline) and membrane depolariz... |
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The adrenergic receptor subtypes present in frog (Rana esculenta) skin
Comp. Biochem. Physiol. C. Toxicol. Pharmacol. 148(2) , 160-4, (2008) Frog skin transports ions and water under hormonal control. In spite of the fundamental role played by adrenergic stimulation in maintaining the water balance of the organism, the receptor subtype(s) present in the skin have not been identified yet. We measur... |
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Might adrenergic alpha2C-agonists/alpha2A-antagonists become novel therapeutic tools for pain treatment with morphine?
J. Med. Chem. 52 , 7319-22, (2009) The imidazoline nucleus linked in position 2 via an oxyethylene bridge to a phenyl ring carrying an ortho substituent of moderate steric bulk provided alpha(2)-adrenergic (AR) ligands endowed with significant alpha(2C)-agonism/alpha(2A)-antagonism. Similar be... |
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alpha(1A)- and alpha(1B)-adrenergic receptors differentially modulate antidepressant-like behavior in the mouse.
Brain Res. 1285 , 148-57, (2009) Tricyclic antidepressant (TCA) drugs are used for the treatment of chronic depression, obsessive-compulsive disorder (OCD), and anxiety-related disorders. Chronic use of TCA drugs increases the expression of alpha(1)-adrenergic receptors (alpha(1)-ARs). Yet, ... |
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Augmentation of alpha1-adrenoceptor-mediated contraction by warming without increased phosphorylation of myosin in rat caudal arterial smooth muscle.
J. Pharmacol. Sci. 99(1) , 61-7, (2005) We previously reported the relationship between alpha1-adrenoceptor-mediated contraction and phosphorylation of 20-kDa myosin light chain (LC20) in de-endothelialized rat caudal arterial smooth muscle at room temperature (Mita M, Walsh MP. Biochem J. 1997;327... |
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Modulation of N-type calcium currents by presynaptic imidazoline receptor activation in rat superior cervical ganglion neurons.
Exp. Physiol. 95(10) , 982-93, (2010) Presynaptic imidazoline receptors (R(i-pre)) are found in the sympathetic axon terminals of animal and human cardiovascular systems, and they regulate blood pressure by modulating the release of peripheral noradrenaline (NA). The cellular mechanism of R(i-pre... |
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Alpha 1-adrenoceptor agonists protect against stress-induced death of neural progenitor cells.
Eur. J. Pharmacol. 573(1-3) , 20-8, (2007) Here, we show that alpha(1)-adrenoceptor agonists suppress stress-induced death of mouse embryonic brain-derived neural progenitor cells (NPCs). NPCs highly expressed both alpha(1A)- and alpha(1B)-adrenoceptor genes, whereas the gene encoding alpha(1D)-adreno... |