zpck
zpck structure
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Common Name | zpck | ||
|---|---|---|---|---|
| CAS Number | 26049-94-5 | Molecular Weight | 331.793 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 503.1±50.0 °C at 760 mmHg | |
| Molecular Formula | C18H18ClNO3 | Melting Point | 107-108ºC(lit.) | |
| MSDS | Chinese USA | Flash Point | 258.1±30.1 °C | |
| Symbol |
GHS05 |
Signal Word | Danger | |
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High-content positional biosensor screening assay for compounds to prevent or disrupt androgen receptor and transcriptional intermediary factor 2 protein-protein interactions.
Assay Drug Dev. Technol. 12(7) , 395-418, (2014) The androgen receptor-transcriptional intermediary factor 2 (AR-TIF2) positional protein-protein interaction (PPI) biosensor assay described herein combines physiologically relevant cell-based assays with the specificity of binding assays by incorporating str... |
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Inhibition of carboxypeptidase Y by chloromethyl ketone derivatives of benzyloxycarbonyl-L-phenylalanine.
J. Biochem. (Tokyo) 76 , 1355, (1974)
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A chemical-genetic interaction map of small molecules using high-throughput imaging in cancer cells.
Mol. Syst. Biol. 11 , 846, (2015) Small molecules often affect multiple targets, elicit off-target effects, and induce genotype-specific responses. Chemical genetics, the mapping of the genotype dependence of a small molecule's effects across a broad spectrum of phenotypes can identify novel ... |
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Inactivation of chymotrypsin and human skin chymase: kinetics of time-dependent inhibition in the presence of substrate.
Biochim. Biophys. Acta 953(3) , 269-79, (1988) The reaction of chymase, a chymotryptic proteinase from human skin, and bovine pancreatic chymotrypsin with a number of time-dependent inhibitors has been studied. An integrated equation, relating product formation with time, has been derived for the reaction... |
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Effect of protease inhibitors and substrates on 3,5,3'-triiodothyronine binding to rat liver nuclear receptors.
Endocr. Regul. 26 , 127-131, (1992) The effect of protease inhibitors N-tosyl-L-phenylalanine chloromethyl ketone (TPCK) and N-carbobenzoxy-L-phenylalanine chloromethyl ketone (ZPCK) at concentrations ranging from 1.5 x 10(-6) mol/l to 1.5 x 10(-4) mol/l on the specific binding of 3,5,3'-triiod... |
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Identification of the catalytic histidine residue participating in the charge-relay system of carboxypeptidase Y.
Protein Sci. 4(11) , 2433-5, (1995) The essential histidine residue of carboxypeptidase Y (CPY) was modified by a site-specific reagent, a chloromethylketone derivative of benzyloxycarbonyl-L-phenylalanine. The single modified histidine residue was converted to N tau-carboxy-methyl histidine (c... |
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Degradation of T-cell receptor chains in the endoplasmic reticulum is inhibited by inhibitors of cysteine proteases.
Cell Regul. 2(9) , 753-65, (1991) The endoplasmic reticulum, or an organelle closely associated with it, contains proteases that can be used to remove partially assembled or improperly folded proteins. Very little is known at present about the types of protease that degrade these proteins. Th... |
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Biogenesis of vaccina: interrelationship between post-translational cleavage, virus assembly, and maturation.
Virology 117(2) , 341-56, (1982)
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